DOI: 10.1146/annurev.immunol.19.1.475. Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

10.1146/annurev.immunol.19.1.475

Crossref journal-article

Annual Reviews

Annual Review of Immunology (22)

Abstract

The human T cell leukemia virus-1 (HTLV-1) is a retrovirus that causes adult T cell leukemia (ATL) and neurological disorder, the tropical spastic paraparesis (HAM/TSP). The pathogenesis apparently results from the pleiotropic function of Tax protein, which is a key regulator of viral replication. Tax exerts (a) trans-activation and -repression of transcription of different sets of cellular genes through binding to groups of transcription factors and coactivators, (b) dysregulation of cell cycle through binding to inhibitors of CDK4/6, and (c) inhibition of some tumor suppressor proteins. These effects on a wide variety of cellular targets seem to cooperate in promoting cell proliferation. This is an effective viral strategy to amplify its proviral genome through replication of infected cells; ultimately it results in cell transformation and leukemogenesis.

Bibliography

Yoshida, M. (2001). Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control. Annual Review of Immunology, 19(1), 475â496.

Authors 1

Mitsuaki Yoshida (first)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 2:49 p.m.)
Indexed	1 day, 15 hours ago (Sept. 3, 2025, 6:37 a.m.)
Issued	24 years, 5 months ago (April 1, 2001)
Published	24 years, 5 months ago (April 1, 2001)
Published Print	24 years, 5 months ago (April 1, 2001)

Funders 0

None

BibTeX

@article{Yoshida_2001, title={Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control}, volume={19}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.19.1.475}, DOI={10.1146/annurev.immunol.19.1.475}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Yoshida, Mitsuaki}, year={2001}, month=apr, pages={475–496} }

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