Abstract
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
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Dates
Type | When |
---|---|
Created | 23 years, 1 month ago (July 27, 2002, 7:43 a.m.) |
Deposited | 2 years, 4 months ago (April 23, 2023, 2:49 p.m.) |
Indexed | 1 week, 3 days ago (Aug. 27, 2025, 12:22 p.m.) |
Issued | 24 years, 5 months ago (April 1, 2001) |
Published | 24 years, 5 months ago (April 1, 2001) |
Published Print | 24 years, 5 months ago (April 1, 2001) |
@article{Heath_2001, title={Cross-Presentation, Dendritic Cells, Tolerance and Immunity}, volume={19}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.19.1.47}, DOI={10.1146/annurev.immunol.19.1.47}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Heath, William R. and Carbone, Francis R.}, year={2001}, month=apr, pages={47–64} }