DOI: 10.1146/annurev.immunol.15.1.563. THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

10.1146/annurev.immunol.15.1.563

Crossref journal-article

Annual Reviews

Annual Review of Immunology (22)

Abstract

▪ Abstract During the last several years, the mechanism of IFNγ-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFNγ-induced cellular responses. The structure and function of the IFNγ receptor have been defined. The mechanism of IFNγ signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFNγ signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.

Bibliography

Bach, E. A., Aguet, M., & Schreiber, R. D. (1997). THE IFNÎ³ RECEPTOR:A Paradigm for Cytokine Receptor Signaling. Annual Review of Immunology, 15(1), 563â591.

Authors 3

Erika A. Bach (first)
Michel Aguet (additional)
Robert D. Schreiber (additional)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:43 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 2:46 p.m.)
Indexed	2 weeks, 4 days ago (Aug. 7, 2025, 5 p.m.)
Issued	28 years, 4 months ago (April 1, 1997)
Published	28 years, 4 months ago (April 1, 1997)
Published Print	28 years, 4 months ago (April 1, 1997)

Funders 0

None

BibTeX

@article{Bach_1997, title={THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling}, volume={15}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.15.1.563}, DOI={10.1146/annurev.immunol.15.1.563}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Bach, Erika A. and Aguet, Michel and Schreiber, Robert D.}, year={1997}, month=apr, pages={563–591} }

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