DOI: 10.1146/annurev.immunol.15.1.235. NEUTRALIZING ANTIVIRAL B CELL RESPONSES

10.1146/annurev.immunol.15.1.235

Crossref journal-article

Annual Reviews

Annual Review of Immunology (22)

Abstract

▪ Abstract Neutralizing antiviral B cell responses differ in various aspects from the many usually measured B cell responses specific for protein in adjuvants. In particular, such neutralizing antiviral B cell responses are more rapidly induced, reach higher titers, are longer lived, and are efficiently generated without adjuvants. Evidence is summarized here that the repetitiveness of many viral antigens is a key factor responsible for the efficiency of these B cell responses, amplifying B cells early and rapidly for potent IgM responses and also for efficient switching to IgG. The data reviewed indicate that B cells discriminate antigen patterns via the degree of surface Ig-cross-linking and use antigen repetitiveness as a self/nonself discriminator.

Bibliography

Bachmann, M. F., & Zinkernagel, R. M. (1997). NEUTRALIZING ANTIVIRAL B CELL RESPONSES. Annual Review of Immunology, 15(1), 235â270.

Authors 2

Martin F. Bachmann (first)
Rolf M. Zinkernagel (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 2:45 p.m.)
Indexed	1 week, 3 days ago (Aug. 21, 2025, 2:02 p.m.)
Issued	28 years, 5 months ago (April 1, 1997)
Published	28 years, 5 months ago (April 1, 1997)
Published Print	28 years, 5 months ago (April 1, 1997)

Funders 0

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BibTeX

@article{Bachmann_1997, title={NEUTRALIZING ANTIVIRAL B CELL RESPONSES}, volume={15}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.15.1.235}, DOI={10.1146/annurev.immunol.15.1.235}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Bachmann, Martin F. and Zinkernagel, Rolf M.}, year={1997}, month=apr, pages={235–270} }

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