DOI: 10.1146/annurev.immunol.14.1.259. T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

10.1146/annurev.immunol.14.1.259

Crossref journal-article

Annual Reviews

Annual Review of Immunology (22)

Abstract

▪ Abstract The T cell antigen receptor (TCR) regulates the activation and growth of T lymphocytes. The initial membrane proximal event triggered by the TCR is activation of protein tyrosine kinases with the resultant phosphorylation of cellular proteins. This biochemical response couples the TCR to a divergent array of signal transduction molecules including enzymes that regulate lipid metabolism, GTP binding proteins, serine/threonine kinases, and adapter molecules. The ultimate aim of studies of intracellular signaling mechanisms is to understand the functional consequences of a particular biochemical event for receptor function. The control of cytokine gene expression is one of the mechanisms that allows the TCR to control immune responses. Accordingly, one object of the present review is to discuss the role of the different TCR signal transduction pathways in linking the TCR to nuclear targets: the transcription factors that control the expression of cytokine genes.

Bibliography

Cantrell, D. (1996). T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS. Annual Review of Immunology, 14(1), 259â274.

Authors 1

Doreen Cantrell (first)

References 91 Referenced 536

10.1016/0092-8674(93)90221-B
10.1016/0092-8674(94)90334-4
{'key': 'b3', 'volume-title': 'Conserved Signaling Motifs in Antigen and Fc Receptors. Seminars in Immunology,', 'author': 'Cambier J', 'year': '1995'} / Conserved Signaling Motifs in Antigen and Fc Receptors. Seminars in Immunology, by Cambier J (1995)
10.1038/338383b0
10.1002/j.1460-2075.1994.tb06237.x
10.1128/MCB.14.2.1095
10.1016/S0021-9258(19)73981-7 / J. Biol. Chem. by Samelson LE (1992)
10.1128/MCB.14.6.3729
10.1126/science.7509083
10.1074/jbc.270.6.2791
10.1084/jem.181.1.375
10.1002/eji.1830221135
10.4049/jimmunol.149.6.1847 / J. Immunol. by Egerton M (1992)
10.1002/j.1460-2075.1992.tb05436.x
10.1038/356071a0
10.1016/S0021-9258(17)31595-8 / J. Biol. Chem. by Donovan JA (1994)
10.1126/science.8235613
10.1128/MCB.14.7.4435
10.1002/eji.1830220108
10.1146/annurev.iy.11.040193.001203
10.1016/0167-5699(94)90080-9
10.1002/eji.1830231029
10.1016/S0021-9258(18)82053-1 / J. Biol. Chem. by Reif K (1993)
10.1038/369327a0
10.1084/jem.179.3.1071
10.1016/S0021-9258(17)32187-7 / J. Biol. Chem. by Carrera AC (1994)
10.1016/S0021-9258(17)36584-5 / J. Biol. Chem. by Exley M (1994)
10.1016/S0021-9258(18)35916-7 / J. Biol. Chem. by Ward SG (1992)
10.1073/pnas.90.15.7366
10.1128/MCB.13.12.7708
10.1128/MCB.15.1.326
10.1038/371426a0
10.1016/0092-8674(94)90148-1
10.1016/0092-8674(95)90534-0
10.1016/0968-0004(93)90071-T
10.1128/MCB.12.7.3305
10.1016/S0959-437X(05)80315-6
10.1038/363015a0
{'key': 'b39', 'first-page': '71', 'volume': '4', 'author': 'McCormick F', 'year': '1994', 'journal-title': 'Curr. Biol.'} / Curr. Biol. by McCormick F (1994)
10.1016/S0021-9258(17)37070-9 / J. Biol. Chem. by Buday L (1994)
10.1084/jem.180.3.1067
10.1016/S0021-9258(17)37491-4 / J. Biol. Chem. by Zhu X (1994)
10.1074/jbc.270.23.13981
10.1074/jbc.270.7.2893
10.1126/science.8484124
{'key': 'b46', 'first-page': '2405', 'volume': '9', 'author': 'Bustelo XR', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene by Bustelo XR (1994)
10.1038/374467a0
10.1038/374474a0
10.1038/374470a0
10.1038/346719a0
10.1126/science.2783497
10.1016/0167-5699(92)90111-J
10.4049/jimmunol.150.9.3853 / J. Immunol. by Woodrow M (1993)
10.1002/j.1460-2075.1992.tb05556.x
10.1016/0167-5699(94)90007-8
10.1038/369497a0
10.1016/1074-7613(95)90027-6
10.1038/357695a0
10.1084/jem.178.5.1517
10.1074/jbc.270.17.9833
10.1002/eji.1830250109
10.1002/eji.1830241031
10.1016/0167-5699(95)80134-0
10.1002/j.1460-2075.1995.tb07001.x
10.1016/S0960-9822(00)00251-7
10.1038/364308a0
10.1084/jem.178.4.1199
10.1016/0959-437X(94)90095-7
10.1016/0092-8674(92)90361-F
10.1091/mbc.3.1.123
10.1002/j.1460-2075.1993.tb06121.x
10.1084/jem.180.1.401
10.1016/0092-8674(93)90237-K
10.1016/0092-8674(92)90162-6
10.1038/373620a0
10.1016/0092-8674(94)90056-6
10.1016/0959-437X(94)90094-9
10.1016/0092-8674(95)90370-4
10.1038/374457a0
10.1016/S0092-8674(05)80020-0
10.1016/S0021-9258(18)31673-9 / J. Biol. Chem. by Katzav S (1994)
10.1084/jem.179.4.1163
10.1016/S0021-9258(17)36757-1 / J. Biol. Chem. by Reif K (1994)
10.1016/S0021-9258(17)31848-3 / J. Biol. Chem. by Motto DG (1994)
10.1128/MCB.15.7.3571
10.1074/jbc.270.13.7029
10.1128/MCB.15.1.186
10.1016/0092-8674(94)90080-9
10.1126/science.7824949
10.1126/science.1532456
10.1016/0092-8674(92)90032-8

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:40 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 2:20 p.m.)
Indexed	3 weeks, 2 days ago (Aug. 6, 2025, 8:54 a.m.)
Issued	29 years, 4 months ago (April 1, 1996)
Published	29 years, 4 months ago (April 1, 1996)
Published Print	29 years, 4 months ago (April 1, 1996)

Funders 0

None

BibTeX

@article{Cantrell_1996, title={T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS}, volume={14}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.14.1.259}, DOI={10.1146/annurev.immunol.14.1.259}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Cantrell, Doreen}, year={1996}, month=apr, pages={259–274} }

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