Genetic Analysis of Tyrosine Kinase Function in B Cell Development
10.1146/annurev.immunol.14.1.131
Crossref journal-article
Annual Reviews
Annual Review of Immunology (22)
Abstract

B lymphopoiesis is regulated by multiple signals from stromal cell contact, soluble cytokines, antigen, and T helper cells. In vitro and biochemical experiments have implicated tyrosine kinases as key components of many of these signaling pathways. Genetic analysis of the role of these tyrosine kinases has been facilitated by recent advances in transgenic and gene targeting technology as well as by the identification of the genetic basis of several human and murine immune deficiencies. This review discusses the effect of gain and loss of function mutations of selected tyrosine kinases and their regulators and substrates on B cell development and function.

Bibliography

Satterthwaite, A., & Witte, O. (1996). Genetic Analysis of Tyrosine Kinase Function in B Cell Development. Annual Review of Immunology, 14(1), 131–154.

Authors 2
  1. Anne Satterthwaite (first)
  2. Owen Witte (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited 2 years, 4 months ago (April 23, 2023, 2:44 p.m.)
Indexed 5 months ago (March 30, 2025, 2:02 p.m.)
Issued 29 years, 4 months ago (April 1, 1996)
Published 29 years, 4 months ago (April 1, 1996)
Published Print 29 years, 4 months ago (April 1, 1996)
Funders 0

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@article{Satterthwaite_1996, title={Genetic Analysis of Tyrosine Kinase Function in B Cell Development}, volume={14}, ISSN={1545-3278}, url={http://dx.doi.org/10.1146/annurev.immunol.14.1.131}, DOI={10.1146/annurev.immunol.14.1.131}, number={1}, journal={Annual Review of Immunology}, publisher={Annual Reviews}, author={Satterthwaite, Anne and Witte, Owen}, year={1996}, month=apr, pages={131–154} }