Translational Regulation and RNA Localization in Drosophila Oocytes and Embryos
10.1146/annurev.genet.35.102401.090756
Crossref journal-article
Annual Reviews
Annual Review of Genetics (22)
Abstract

▪ Abstract  Translational control is a prevalent means of gene regulation during Drosophila oogenesis and embryogenesis. Multiple maternal mRNAs are localized within the oocyte, and this localization is often coupled to their translational regulation. Subsequently, translational control allows maternally deposited mRNAs to direct the early stages of embryonic development. In this review we outline some general mechanisms of translational regulation and mRNA localization that have been uncovered in various model systems. Then we focus on the posttranscriptional regulation of four maternal transcripts in Drosophila that are localized during oogenesis and are critical for embryonic patterning: bicoid (bcd), nanos (nos), oskar (osk), and gurken (grk). Cis- and trans-acting factors required for the localization and translational control of these mRNAs are discussed along with potential mechanisms for their regulation.

Bibliography

Johnstone, O., & Lasko, P. (2001). Translational Regulation and RNA Localization in Drosophila Oocytes and Embryos. Annual Review of Genetics, 35(1), 365–406.

Authors 2
  1. Oona Johnstone (first)
  2. Paul Lasko (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 7:43 a.m.)
Deposited 3 years, 10 months ago (Oct. 12, 2021, 4:19 a.m.)
Indexed 2 weeks, 5 days ago (Aug. 7, 2025, 4:52 a.m.)
Issued 23 years, 8 months ago (Dec. 1, 2001)
Published 23 years, 8 months ago (Dec. 1, 2001)
Published Print 23 years, 8 months ago (Dec. 1, 2001)
Funders 0

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@article{Johnstone_2001, title={Translational Regulation and RNA Localization in Drosophila Oocytes and Embryos}, volume={35}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.35.102401.090756}, DOI={10.1146/annurev.genet.35.102401.090756}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Johnstone, Oona and Lasko, Paul}, year={2001}, month=dec, pages={365–406} }