DOI: 10.1146/annurev.genet.35.102401.090313. The Action of Molecular Chaperones in the Early Secretory Pathway

The Action of Molecular Chaperones in the Early Secretory Pathway

10.1146/annurev.genet.35.102401.090313

Crossref journal-article

Annual Reviews

Annual Review of Genetics (22)

Abstract

▪ Abstract The endoplasmic reticulum (ER) serves as a way-station during the biogenesis of nearly all secreted proteins, and associated with or housed within the ER are factors required to catalyze their import into the ER and facilitate their folding. To ensure that only properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target aberrant proteins for degradation and/or adapt to the accumulation of misfolded proteins. Molecular chaperones play critical roles in each of these phenomena.

Bibliography

Fewell, S. W., Travers, K. J., Weissman, J. S., & Brodsky, J. L. (2001). The Action of Molecular Chaperones in the Early Secretory Pathway. Annual Review of Genetics, 35(1), 149â191.

Authors 4

Sheara W. Fewell (first)
Kevin J. Travers (additional)
Jonathan S. Weissman (additional)
Jeffrey L. Brodsky (additional)

References 299 Referenced 246

10.1126/science.181.4096.223
10.1242/jcs.112.19.3309 / J. Cell Sci. by Ayalon-Soffer M (1999)
10.1016/S0092-8674(00)81016-8
10.1002/j.1460-2075.1994.tb06816.x
10.1128/MCB.19.6.4535
10.1074/jbc.271.25.14840
10.1016/S0092-8674(00)80929-0
10.1128/MCB.16.11.6444
10.1038/35050524
10.1074/jbc.273.45.29873
10.1128/MCB.16.8.4378
10.1126/science.278.5346.2123
10.1126/science.2188360
10.1093/emboj/19.17.4493
10.1074/jbc.M006572200
10.1038/35014014
10.1002/j.1460-2075.1996.tb00560.x
10.1126/science.278.5344.1806
10.1016/0092-8674(93)90492-9
10.1074/jbc.273.47.30903
10.1091/mbc.9.1.209
10.1126/science.274.5293.1715
10.1002/j.1460-2075.1992.tb05223.x
10.1038/12043
10.1016/0968-0004(96)30011-X
10.1016/S0014-5793(98)01065-5
10.1073/pnas.92.21.9643
10.1083/jcb.120.1.95
10.1021/bi980900g
10.1006/scdb.1999.0321
10.1083/jcb.123.6.1355
10.1074/jbc.274.6.3453
10.1016/S0092-8674(00)80675-3
10.1016/S0092-8674(00)80928-9
10.1083/jcb.135.5.1229
10.1074/jbc.275.7.4827
10.1016/S0962-8924(99)01580-9
10.1016/S0092-8674(05)80063-7
10.1016/S1097-2765(00)80251-8
10.1016/S1097-2765(00)80196-3
10.1146/annurev.cellbio.14.1.459
10.1016/S0021-9258(19)75848-7 / J. Biol. Chem. by Chappell TG (1987)
10.1379/1466-1268(1998)003<0028:SFAEOD>2.3.CO;2
10.1515/BC.2000.143
10.1038/332805a0
10.1074/jbc.275.7.4981
10.1016/0092-8674(91)90177-Z
10.1038/35050618
10.1083/jcb.137.7.1483
10.1016/0092-8674(93)90648-A
10.1016/S0092-8674(00)81360-4
10.1091/mbc.8.9.1805
10.1002/j.1460-2075.1996.tb00624.x
10.1016/0092-8674(93)90640-C
10.1038/11047
10.1016/0014-5793(95)00024-4
10.1016/S0021-9258(19)36777-8 / J. Biol. Chem. by Cyr DM (1992)
10.1074/jbc.M008608200
10.1038/332800a0
10.1091/mbc.10.12.4059
10.1074/jbc.273.16.9734
10.1091/mbc.7.1.91
10.1002/j.1460-2075.1996.tb01085.x
10.1016/S0092-8674(00)81115-0
10.1073/pnas.96.23.13050
10.1091/mbc.8.8.1559
10.1046/j.1365-2958.2000.02063.x
10.1126/science.286.5446.1882
10.1083/jcb.143.3.625
10.1074/jbc.M905763199
10.1128/MCB.12.7.3288
10.1093/emboj/17.20.5877
10.1038/353726a0
10.1016/S0962-8924(00)01745-1
10.1016/S1097-2765(00)80017-9
10.1016/S1097-2765(00)80198-7
10.1002/j.1460-2075.1996.tb00660.x
10.1038/35017001
10.1038/370111a0
10.1074/jbc.M006278200
10.1016/S0021-9258(19)74477-9 / J. Biol. Chem. by Gardner AM (1993)
10.1083/jcb.151.1.69
10.1073/pnas.95.26.15229
10.1073/pnas.071057198
10.1038/355033a0
10.1083/jcb.147.7.1443
10.1016/0092-8674(85)90107-2
10.1016/0092-8674(95)90444-1
{'key': 'b89', 'first-page': '1406', 'volume': '238', 'author': 'Goldberger RF', 'year': '1963', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Goldberger RF (1963)
10.1093/emboj/18.11.3119
10.1074/jbc.274.25.17525
10.1074/jbc.M100633200
10.1074/jbc.271.48.30610
10.1016/S0092-8674(00)80235-4
10.1016/S0092-8674(00)81403-8
10.1073/pnas.91.3.913
10.1083/jcb.126.1.41
10.1016/0955-0674(95)80009-3
10.1091/mbc.7.12.2029
10.1073/pnas.94.24.12944
10.1016/S0092-8674(00)81391-4
10.1016/0092-8674(91)90577-L
10.1038/16729
10.1038/367654a0
10.1091/mbc.10.11.3787
10.1021/bi971383p
10.1016/0092-8674(95)90395-X
10.1016/S0092-8674(00)00028-3
10.1126/science.291.5512.2364
10.1093/emboj/19.4.550
10.1021/bi00016a033
10.1126/science.273.5282.1725
10.1093/emboj/16.20.6209
10.1002/j.1460-2075.1996.tb00723.x
10.1083/jcb.135.3.623
10.1016/S0092-8674(00)00080-5
10.1083/jcb.108.6.2117
10.1146/annurev.cb.05.110189.001425
10.1126/science.1523409
10.1016/S1097-2765(00)80335-4
10.1074/jbc.273.18.11183
10.1083/jcb.121.2.317
10.1083/jcb.142.5.1223
10.1002/yea.320100308
10.1002/j.1460-2075.1995.tb00291.x
10.1074/jbc.270.9.4845
10.1016/0092-8674(95)90241-4
10.1146/annurev.cellbio.15.1.799
10.1074/jbc.M005195200
10.1074/jbc.273.6.3679
10.1083/jcb.152.4.851
10.1128/MCB.20.18.6923-6934.2000
10.1074/jbc.271.19.11236
10.1038/70265
10.1091/mbc.8.10.1845
10.1093/emboj/20.1.295
10.1073/pnas.92.5.1764
10.1002/j.1460-2075.1996.tb00411.x
10.1073/pnas.94.22.11857
10.1038/329268a0
10.1038/356683a0
10.1128/MCB.19.5.3588
10.1073/pnas.88.7.2874
10.1006/jmbi.2000.4302
10.1074/jbc.274.9.5861
10.1016/0092-8674(92)90515-E
10.1091/mbc.9.10.2767
10.1074/jbc.273.49.32373
10.1091/mbc.11.9.2973
10.1074/jbc.275.7.4613
10.1083/jcb.131.5.1163
10.1016/S0092-8674(00)81861-9
10.1016/0092-8674(95)90330-5
10.1016/S0092-8674(00)80767-9
10.1093/emboj/17.12.3251
10.1006/jmbi.1995.0284
10.1091/mbc.9.12.3533
10.1093/genetics/156.2.501 / Genetics by McClellan AJ (2000)
10.1083/jcb.132.3.291
10.1093/genetics/144.4.1355 / Genetics by McCracken AA (1996)
10.1074/jbc.271.41.25630
10.1038/35050509
10.1038/370373a0
10.1074/jbc.275.19.14550
10.1016/S1097-2765(00)80158-6
10.1126/science.288.5464.331
10.1046/j.1365-2443.1996.d01-274.x
10.1016/0092-8674(93)90521-Q
10.1002/j.1460-2075.1992.tb05323.x
10.1074/jbc.273.34.22037
10.1021/bi00019a001
10.1016/S0092-8674(00)80234-2
10.1074/jbc.270.29.17139
10.1016/0092-8674(92)90414-8
10.1091/mbc.12.3.577
10.1093/genetics/149.3.1277 / Genetics by Naik RR (1998)
10.1074/jbc.C100023200
10.1073/pnas.94.24.12949
10.1016/0092-8674(92)90269-I
10.1038/35010558
10.1083/jcb.134.2.269
10.1083/jcb.150.1.77
10.1016/0092-8674(93)90276-V
10.1074/jbc.272.20.12889
10.1083/jcb.153.5.1061
10.1016/S0092-8674(00)81667-0
10.1083/jcb.152.3.553
10.1016/0092-8674(89)90059-7
10.1083/jcb.143.4.901
10.1006/bbrc.1996.0314
10.1091/mbc.3.8.895
10.1006/bbrc.2000.3987
10.1074/jbc.M003061200
10.1093/emboj/17.16.4829
10.1002/j.1460-2075.1995.tb07309.x
10.1146/annurev.biochem.69.1.69
10.1016/S0021-9258(20)81931-0 / J. Biol. Chem. by Parodi AJ (1983)
10.1091/mbc.9.4.817
10.1006/jmbi.1996.0395
10.1093/emboj/17.14.3981
10.1093/emboj/16.15.4540
10.1083/jcb.151.1.167
10.1016/S0092-8674(00)81738-9
10.1038/42276
10.1074/jbc.273.49.32848
10.1016/S0968-0004(99)01420-6
10.1016/S1097-2765(00)80018-0
10.1016/S0092-8674(00)80314-1
10.1006/jmbi.1996.0394
10.1074/jbc.271.37.22791
10.1515/BC.1999.145
10.1016/S0962-8924(96)10056-8
10.1002/(SICI)1521-1878(199807)20:7<546::AID-BIES5>3.0.CO;2-I
10.1146/annurev.genet.32.1.163
10.1016/0092-8674(89)90058-5
10.1083/jcb.109.6.2641
10.1093/emboj/16.7.1501
10.1093/emboj/20.5.1042
10.1083/jcb.109.6.2665
10.1016/0092-8674(92)90415-9
10.1083/jcb.137.4.813
10.1038/35046500
Schiebel T, Buchner J. 1997.The Hsp90 family—an overview.InGuidebook to Molecular Chaperones and Protein Folding Catalysts, ed. MJ Gething, pp. 147–51. London: Oxford Univ. Press (10.1093/oso/9780198599494.003.0057)
10.1083/jcb.129.4.979
10.1126/science.8310296
10.1083/jcb.148.6.1203
10.1002/j.1460-2075.1995.tb07092.x
10.1073/pnas.93.25.14536
10.1021/bi961825h
10.1016/S0960-9822(98)70986-8
10.1002/j.1460-2075.1996.tb00666.x
10.1128/MCB.18.12.7499
10.1016/S0092-8674(00)81361-6
10.1016/S0092-8674(00)80369-4
10.1073/pnas.89.9.3770
10.1083/jcb.130.1.41
10.1016/S0014-5793(99)01222-3
10.1073/pnas.95.4.1574
10.1515/BC.1999.142
10.1038/365176a0
10.1016/0092-8674(91)90156-S
10.1016/S0092-8674(00)80203-2
10.1006/scdb.1999.0315
10.1074/jbc.275.8.5565
10.1073/pnas.95.26.15223
10.1074/jbc.274.43.30534
10.1083/jcb.149.5.1039
10.1002/j.1460-2075.1996.tb00371.x
10.1073/pnas.91.22.10345
10.1073/pnas.91.24.11343
10.1111/j.1432-1033.1994.tb18906.x
10.1101/gad.12.12.1812
10.1074/jbc.M001073200
10.1016/S0092-8674(00)80835-1
10.1016/S0092-8674(01)00289-6
10.1074/jbc.271.16.9347
10.1126/science.290.5496.1571
10.1073/pnas.97.13.7214
{'key': 'b259', 'first-page': '794', 'volume': '30', 'author': 'Tyson JR', 'year': '2000', 'journal-title': 'EMBO J.'} / EMBO J. by Tyson JR (2000)
10.1091/mbc.11.10.3425
10.1083/jcb.110.6.1885
10.1146/annurev.biochem.68.1.1015
10.1016/S0021-9258(17)37706-2 / J. Biol. Chem. by Wall D (1994)
10.1074/jbc.270.5.2139
10.1093/emboj/20.12.3124
10.1093/emboj/18.21.5972
10.1016/S0021-9258(19)74274-4 / J. Biol. Chem. by Wang TF (1993)
10.1093/emboj/17.19.5708
10.1016/S0021-9258(19)61473-0 / J. Biol. Chem. by Wang Y (2000)
10.1016/0092-8674(95)90240-6
10.1083/jcb.102.5.1543
{'key': 'b272', 'first-page': '41', 'volume': '77', 'author': 'Wei J', 'year': '1996', 'journal-title': 'EXS'} / EXS by Wei J (1996)
10.1074/jbc.M005980200
10.1073/pnas.89.20.9900
10.1073/pnas.93.24.13797
10.1074/jbc.274.48.34443
10.1038/350165a0
10.1038/384432a0
10.1016/S0021-9258(18)48445-1 / J. Biol. Chem. by Wikstrom L (1992)
10.1101/gad.6.7.1165
10.1091/mbc.1.12.907
10.1091/mbc.2.9.753
10.1074/jbc.275.1.521
10.1074/jbc.M000567200
10.1093/emboj/17.16.4809
10.1016/S1097-2765(00)00133-7
10.1074/jbc.273.50.33741
10.1093/emboj/20.1.262
10.1074/jbc.272.33.20800
10.1016/S0969-2126(99)80112-9
10.1016/S0896-6273(00)80708-4
10.1091/mbc.8.10.1943
10.1091/mbc.12.5.1303
10.1016/0092-8674(93)90646-8
10.1016/S1097-2765(00)80222-1
10.1126/science.272.5268.1606
10.1016/0968-0004(77)90042-1
10.1002/j.1460-2075.1988.tb03144.x
10.1002/j.1460-2075.1989.tb03544.x

Dates

Type	When
Created	23 years ago (July 27, 2002, 7:43 a.m.)
Deposited	1 year, 7 months ago (Jan. 6, 2024, 12:01 a.m.)
Indexed	1 day, 22 hours ago (Aug. 23, 2025, 12:59 a.m.)
Issued	23 years, 8 months ago (Dec. 1, 2001)
Published	23 years, 8 months ago (Dec. 1, 2001)
Published Print	23 years, 8 months ago (Dec. 1, 2001)

Funders 0

None

BibTeX

@article{Fewell_2001, title={The Action of Molecular Chaperones in the Early Secretory Pathway}, volume={35}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.35.102401.090313}, DOI={10.1146/annurev.genet.35.102401.090313}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Fewell, Sheara W. and Travers, Kevin J. and Weissman, Jonathan S. and Brodsky, Jeffrey L.}, year={2001}, month=dec, pages={149–191} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        23
      ]
    ],
    "date-time": "2025-08-23T04:59:12Z",
    "timestamp": 1755925152825
  },
  "reference-count": 299,
  "publisher": "Annual Reviews",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  },
  "abstract": "<jats:p>\u25aa Abstract\u2002 The endoplasmic reticulum (ER) serves as a way-station during the biogenesis of nearly all secreted proteins, and associated with or housed within the ER are factors required to catalyze their import into the ER and facilitate their folding. To ensure that only properly folded proteins are secreted and to temper the effects of cellular stress, the ER can target aberrant proteins for degradation and/or adapt to the accumulation of misfolded proteins. Molecular chaperones play critical roles in each of these phenomena.</jats:p>",
  "DOI": "10.1146/annurev.genet.35.102401.090313",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        27
      ]
    ],
    "date-time": "2002-07-27T11:43:05Z",
    "timestamp": 1027770185000
  },
  "page": "149-191",
  "source": "Crossref",
  "is-referenced-by-count": 246,
  "title": "The Action of Molecular Chaperones in the Early Secretory Pathway",
  "prefix": "10.1146",
  "volume": "35",
  "author": [
    {
      "given": "Sheara W.",
      "family": "Fewell",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;"
        },
        {
          "name": "Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, California 94143"
        }
      ]
    },
    {
      "given": "Kevin J.",
      "family": "Travers",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;"
        },
        {
          "name": "Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, California 94143"
        }
      ]
    },
    {
      "given": "Jonathan S.",
      "family": "Weissman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;"
        },
        {
          "name": "Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, California 94143"
        }
      ]
    },
    {
      "given": "Jeffrey L.",
      "family": "Brodsky",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260;"
        },
        {
          "name": "Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, California 94143"
        }
      ]
    }
  ],
  "member": "22",
  "reference": [
    {
      "key": "b1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.181.4096.223"
    },
    {
      "key": "b2",
      "doi-asserted-by": "crossref",
      "first-page": "3309",
      "DOI": "10.1242/jcs.112.19.3309",
      "volume": "112",
      "author": "Ayalon-Soffer M",
      "year": "1999",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81016-8"
    },
    {
      "key": "b4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06816.x"
    },
    {
      "key": "b5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.19.6.4535"
    },
    {
      "key": "b6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.25.14840"
    },
    {
      "key": "b7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80929-0"
    },
    {
      "key": "b8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.11.6444"
    },
    {
      "key": "b9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35050524"
    },
    {
      "key": "b10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.45.29873"
    },
    {
      "key": "b11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.8.4378"
    },
    {
      "key": "b12",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5346.2123"
    },
    {
      "key": "b13",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2188360"
    },
    {
      "key": "b14",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/19.17.4493"
    },
    {
      "key": "b15",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M006572200"
    },
    {
      "key": "b16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35014014"
    },
    {
      "key": "b17",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00560.x"
    },
    {
      "key": "b18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.278.5344.1806"
    },
    {
      "key": "b19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90492-9"
    },
    {
      "key": "b20",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.47.30903"
    },
    {
      "key": "b21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.9.1.209"
    },
    {
      "key": "b22",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.274.5293.1715"
    },
    {
      "key": "b23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05223.x"
    },
    {
      "key": "b24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/12043"
    },
    {
      "key": "b25",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(96)30011-X"
    },
    {
      "key": "b26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(98)01065-5"
    },
    {
      "key": "b27",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.21.9643"
    },
    {
      "key": "b28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.120.1.95"
    },
    {
      "key": "b29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi980900g"
    },
    {
      "key": "b30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/scdb.1999.0321"
    },
    {
      "key": "b31",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.123.6.1355"
    },
    {
      "key": "b32",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.6.3453"
    },
    {
      "key": "b33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80675-3"
    },
    {
      "key": "b34",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80928-9"
    },
    {
      "key": "b35",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.135.5.1229"
    },
    {
      "key": "b36",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.7.4827"
    },
    {
      "key": "b37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(99)01580-9"
    },
    {
      "key": "b38",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(05)80063-7"
    },
    {
      "key": "b39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80251-8"
    },
    {
      "key": "b40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80196-3"
    },
    {
      "key": "b41",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cellbio.14.1.459"
    },
    {
      "key": "b42",
      "doi-asserted-by": "crossref",
      "first-page": "746",
      "DOI": "10.1016/S0021-9258(19)75848-7",
      "volume": "262",
      "author": "Chappell TG",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1379/1466-1268(1998)003<0028:SFAEOD>2.3.CO;2"
    },
    {
      "key": "b44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1515/BC.2000.143"
    },
    {
      "key": "b45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332805a0"
    },
    {
      "key": "b46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.7.4981"
    },
    {
      "key": "b47",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90177-Z"
    },
    {
      "key": "b48",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35050618"
    },
    {
      "key": "b49",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.137.7.1483"
    },
    {
      "key": "b50",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90648-A"
    },
    {
      "key": "b51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81360-4"
    },
    {
      "key": "b52",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.8.9.1805"
    },
    {
      "key": "b53",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00624.x"
    },
    {
      "key": "b54",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90640-C"
    },
    {
      "key": "b55",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/11047"
    },
    {
      "key": "b56",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(95)00024-4"
    },
    {
      "key": "b57",
      "doi-asserted-by": "crossref",
      "first-page": "20927",
      "DOI": "10.1016/S0021-9258(19)36777-8",
      "volume": "267",
      "author": "Cyr DM",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b58",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M008608200"
    },
    {
      "key": "b59",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/332800a0"
    },
    {
      "key": "b60",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.10.12.4059"
    },
    {
      "key": "b61",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.16.9734"
    },
    {
      "key": "b62",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.7.1.91"
    },
    {
      "key": "b63",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb01085.x"
    },
    {
      "key": "b64",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81115-0"
    },
    {
      "key": "b65",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.96.23.13050"
    },
    {
      "key": "b66",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.8.8.1559"
    },
    {
      "key": "b67",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1365-2958.2000.02063.x"
    },
    {
      "key": "b68",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.286.5446.1882"
    },
    {
      "key": "b69",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.143.3.625"
    },
    {
      "key": "b70",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M905763199"
    },
    {
      "key": "b71",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.12.7.3288"
    },
    {
      "key": "b72",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.20.5877"
    },
    {
      "key": "b73",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/353726a0"
    },
    {
      "key": "b74",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(00)01745-1"
    },
    {
      "key": "b75",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80017-9"
    },
    {
      "key": "b76",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80198-7"
    },
    {
      "key": "b77",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00660.x"
    },
    {
      "key": "b78",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35017001"
    },
    {
      "key": "b79",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/370111a0"
    },
    {
      "key": "b80",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M006278200"
    },
    {
      "key": "b81",
      "doi-asserted-by": "crossref",
      "first-page": "25940",
      "DOI": "10.1016/S0021-9258(19)74477-9",
      "volume": "268",
      "author": "Gardner AM",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b82",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.151.1.69"
    },
    {
      "key": "b83",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.26.15229"
    },
    {
      "key": "b84",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.071057198"
    },
    {
      "key": "b85",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/355033a0"
    },
    {
      "key": "b86",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.147.7.1443"
    },
    {
      "key": "b87",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(85)90107-2"
    },
    {
      "key": "b88",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90444-1"
    },
    {
      "key": "b89",
      "first-page": "1406",
      "volume": "238",
      "author": "Goldberger RF",
      "year": "1963",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b90",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/18.11.3119"
    },
    {
      "key": "b91",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.25.17525"
    },
    {
      "key": "b92",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M100633200"
    },
    {
      "key": "b93",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.48.30610"
    },
    {
      "key": "b94",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80235-4"
    },
    {
      "key": "b95",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81403-8"
    },
    {
      "key": "b96",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.3.913"
    },
    {
      "key": "b97",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.126.1.41"
    },
    {
      "key": "b98",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0955-0674(95)80009-3"
    },
    {
      "key": "b99",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.7.12.2029"
    },
    {
      "key": "b100",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.24.12944"
    },
    {
      "key": "b101",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81391-4"
    },
    {
      "key": "b102",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90577-L"
    },
    {
      "key": "b103",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/16729"
    },
    {
      "key": "b104",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/367654a0"
    },
    {
      "key": "b105",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.10.11.3787"
    },
    {
      "key": "b106",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi971383p"
    },
    {
      "key": "b107",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90395-X"
    },
    {
      "key": "b108",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00028-3"
    },
    {
      "key": "b109",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.291.5512.2364"
    },
    {
      "key": "b110",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/19.4.550"
    },
    {
      "key": "b111",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00016a033"
    },
    {
      "key": "b112",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.273.5282.1725"
    },
    {
      "key": "b113",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.20.6209"
    },
    {
      "key": "b114",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00723.x"
    },
    {
      "key": "b115",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.135.3.623"
    },
    {
      "key": "b116",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)00080-5"
    },
    {
      "key": "b117",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.108.6.2117"
    },
    {
      "key": "b118",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cb.05.110189.001425"
    },
    {
      "key": "b119",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.1523409"
    },
    {
      "key": "b120",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80335-4"
    },
    {
      "key": "b121",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.18.11183"
    },
    {
      "key": "b122",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.121.2.317"
    },
    {
      "key": "b123",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.142.5.1223"
    },
    {
      "key": "b124",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/yea.320100308"
    },
    {
      "key": "b125",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1995.tb00291.x"
    },
    {
      "key": "b126",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.9.4845"
    },
    {
      "key": "b127",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90241-4"
    },
    {
      "key": "b128",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cellbio.15.1.799"
    },
    {
      "key": "b129",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M005195200"
    },
    {
      "key": "b130",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.6.3679"
    },
    {
      "key": "b131",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.152.4.851"
    },
    {
      "key": "b132",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.20.18.6923-6934.2000"
    },
    {
      "key": "b133",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.19.11236"
    },
    {
      "key": "b134",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/70265"
    },
    {
      "key": "b135",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.8.10.1845"
    },
    {
      "key": "b136",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/20.1.295"
    },
    {
      "key": "b137",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.5.1764"
    },
    {
      "key": "b138",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00411.x"
    },
    {
      "key": "b139",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.22.11857"
    },
    {
      "key": "b140",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/329268a0"
    },
    {
      "key": "b141",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/356683a0"
    },
    {
      "key": "b142",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.19.5.3588"
    },
    {
      "key": "b143",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.88.7.2874"
    },
    {
      "key": "b144",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.2000.4302"
    },
    {
      "key": "b145",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.9.5861"
    },
    {
      "key": "b146",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90515-E"
    },
    {
      "key": "b147",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.9.10.2767"
    },
    {
      "key": "b148",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.49.32373"
    },
    {
      "key": "b149",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.11.9.2973"
    },
    {
      "key": "b150",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.7.4613"
    },
    {
      "key": "b151",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.131.5.1163"
    },
    {
      "key": "b152",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81861-9"
    },
    {
      "key": "b153",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90330-5"
    },
    {
      "key": "b154",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80767-9"
    },
    {
      "key": "b155",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.12.3251"
    },
    {
      "key": "b156",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1995.0284"
    },
    {
      "key": "b157",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.9.12.3533"
    },
    {
      "key": "b158",
      "doi-asserted-by": "crossref",
      "first-page": "501",
      "DOI": "10.1093/genetics/156.2.501",
      "volume": "156",
      "author": "McClellan AJ",
      "year": "2000",
      "journal-title": "Genetics"
    },
    {
      "key": "b159",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.132.3.291"
    },
    {
      "key": "b160",
      "doi-asserted-by": "crossref",
      "first-page": "1355",
      "DOI": "10.1093/genetics/144.4.1355",
      "volume": "144",
      "author": "McCracken AA",
      "year": "1996",
      "journal-title": "Genetics"
    },
    {
      "key": "b161",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.41.25630"
    },
    {
      "key": "b162",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35050509"
    },
    {
      "key": "b163",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/370373a0"
    },
    {
      "key": "b164",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.19.14550"
    },
    {
      "key": "b165",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80158-6"
    },
    {
      "key": "b166",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.288.5464.331"
    },
    {
      "key": "b167",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1365-2443.1996.d01-274.x"
    },
    {
      "key": "b168",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90521-Q"
    },
    {
      "key": "b169",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05323.x"
    },
    {
      "key": "b170",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.34.22037"
    },
    {
      "key": "b171",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00019a001"
    },
    {
      "key": "b172",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80234-2"
    },
    {
      "key": "b173",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.29.17139"
    },
    {
      "key": "b174",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90414-8"
    },
    {
      "key": "b175",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.12.3.577"
    },
    {
      "key": "b176",
      "doi-asserted-by": "crossref",
      "first-page": "1277",
      "DOI": "10.1093/genetics/149.3.1277",
      "volume": "149",
      "author": "Naik RR",
      "year": "1998",
      "journal-title": "Genetics"
    },
    {
      "key": "b177",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.C100023200"
    },
    {
      "key": "b178",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.24.12949"
    },
    {
      "key": "b179",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90269-I"
    },
    {
      "key": "b180",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35010558"
    },
    {
      "key": "b181",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.134.2.269"
    },
    {
      "key": "b182",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.150.1.77"
    },
    {
      "key": "b183",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90276-V"
    },
    {
      "key": "b184",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.20.12889"
    },
    {
      "key": "b185",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.153.5.1061"
    },
    {
      "key": "b186",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81667-0"
    },
    {
      "key": "b187",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.152.3.553"
    },
    {
      "key": "b188",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90059-7"
    },
    {
      "key": "b189",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.143.4.901"
    },
    {
      "key": "b190",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1996.0314"
    },
    {
      "key": "b191",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.3.8.895"
    },
    {
      "key": "b192",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.2000.3987"
    },
    {
      "key": "b193",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M003061200"
    },
    {
      "key": "b194",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.16.4829"
    },
    {
      "key": "b195",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1995.tb07309.x"
    },
    {
      "key": "b196",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.biochem.69.1.69"
    },
    {
      "key": "b197",
      "doi-asserted-by": "crossref",
      "first-page": "5589",
      "DOI": "10.1016/S0021-9258(20)81931-0",
      "volume": "258",
      "author": "Parodi AJ",
      "year": "1983",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b198",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.9.4.817"
    },
    {
      "key": "b199",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1996.0395"
    },
    {
      "key": "b200",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.14.3981"
    },
    {
      "key": "b201",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.15.4540"
    },
    {
      "key": "b202",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.151.1.167"
    },
    {
      "key": "b203",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81738-9"
    },
    {
      "key": "b204",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/42276"
    },
    {
      "key": "b205",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.49.32848"
    },
    {
      "key": "b206",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0968-0004(99)01420-6"
    },
    {
      "key": "b207",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80018-0"
    },
    {
      "key": "b208",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80314-1"
    },
    {
      "key": "b209",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/jmbi.1996.0394"
    },
    {
      "key": "b210",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.37.22791"
    },
    {
      "key": "b211",
      "doi-asserted-by": "publisher",
      "DOI": "10.1515/BC.1999.145"
    },
    {
      "key": "b212",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0962-8924(96)10056-8"
    },
    {
      "key": "b213",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1521-1878(199807)20:7<546::AID-BIES5>3.0.CO;2-I"
    },
    {
      "key": "b214",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.genet.32.1.163"
    },
    {
      "key": "b215",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(89)90058-5"
    },
    {
      "key": "b216",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.109.6.2641"
    },
    {
      "key": "b217",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.7.1501"
    },
    {
      "key": "b218",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/20.5.1042"
    },
    {
      "key": "b219",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.109.6.2665"
    },
    {
      "key": "b220",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90415-9"
    },
    {
      "key": "b221",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.137.4.813"
    },
    {
      "key": "b222",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/35046500"
    },
    {
      "key": "b223",
      "doi-asserted-by": "crossref",
      "unstructured": "Schiebel T, Buchner J. 1997.The Hsp90 family\u2014an overview.InGuidebook to Molecular Chaperones and Protein Folding Catalysts, ed. MJ Gething, pp. 147\u201351. London: Oxford Univ. Press",
      "DOI": "10.1093/oso/9780198599494.003.0057"
    },
    {
      "key": "b224",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.129.4.979"
    },
    {
      "key": "b225",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.8310296"
    },
    {
      "key": "b226",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.148.6.1203"
    },
    {
      "key": "b227",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1995.tb07092.x"
    },
    {
      "key": "b228",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.25.14536"
    },
    {
      "key": "b229",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi961825h"
    },
    {
      "key": "b230",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(98)70986-8"
    },
    {
      "key": "b231",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00666.x"
    },
    {
      "key": "b232",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.18.12.7499"
    },
    {
      "key": "b233",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81361-6"
    },
    {
      "key": "b234",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80369-4"
    },
    {
      "key": "b235",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.9.3770"
    },
    {
      "key": "b236",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.130.1.41"
    },
    {
      "key": "b237",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0014-5793(99)01222-3"
    },
    {
      "key": "b238",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.4.1574"
    },
    {
      "key": "b239",
      "doi-asserted-by": "publisher",
      "DOI": "10.1515/BC.1999.142"
    },
    {
      "key": "b240",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/365176a0"
    },
    {
      "key": "b241",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(91)90156-S"
    },
    {
      "key": "b242",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80203-2"
    },
    {
      "key": "b243",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/scdb.1999.0315"
    },
    {
      "key": "b244",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.8.5565"
    },
    {
      "key": "b245",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.95.26.15223"
    },
    {
      "key": "b246",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.43.30534"
    },
    {
      "key": "b247",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.149.5.1039"
    },
    {
      "key": "b248",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00371.x"
    },
    {
      "key": "b249",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.22.10345"
    },
    {
      "key": "b250",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.24.11343"
    },
    {
      "key": "b251",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1994.tb18906.x"
    },
    {
      "key": "b252",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.12.12.1812"
    },
    {
      "key": "b253",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M001073200"
    },
    {
      "key": "b254",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80835-1"
    },
    {
      "key": "b255",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(01)00289-6"
    },
    {
      "key": "b256",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.16.9347"
    },
    {
      "key": "b257",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.290.5496.1571"
    },
    {
      "key": "b258",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.97.13.7214"
    },
    {
      "key": "b259",
      "first-page": "794",
      "volume": "30",
      "author": "Tyson JR",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "b260",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.11.10.3425"
    },
    {
      "key": "b261",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.110.6.1885"
    },
    {
      "key": "b262",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.biochem.68.1.1015"
    },
    {
      "key": "b263",
      "doi-asserted-by": "crossref",
      "first-page": "5446",
      "DOI": "10.1016/S0021-9258(17)37706-2",
      "volume": "269",
      "author": "Wall D",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b264",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.5.2139"
    },
    {
      "key": "b265",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/20.12.3124"
    },
    {
      "key": "b266",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/18.21.5972"
    },
    {
      "key": "b267",
      "doi-asserted-by": "crossref",
      "first-page": "26049",
      "DOI": "10.1016/S0021-9258(19)74274-4",
      "volume": "268",
      "author": "Wang TF",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b268",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.19.5708"
    },
    {
      "key": "b269",
      "doi-asserted-by": "crossref",
      "first-page": "27013",
      "DOI": "10.1016/S0021-9258(19)61473-0",
      "volume": "275",
      "author": "Wang Y",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b270",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90240-6"
    },
    {
      "key": "b271",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.102.5.1543"
    },
    {
      "key": "b272",
      "first-page": "41",
      "volume": "77",
      "author": "Wei J",
      "year": "1996",
      "journal-title": "EXS"
    },
    {
      "key": "b273",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M005980200"
    },
    {
      "key": "b274",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.20.9900"
    },
    {
      "key": "b275",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.24.13797"
    },
    {
      "key": "b276",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.274.48.34443"
    },
    {
      "key": "b277",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/350165a0"
    },
    {
      "key": "b278",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/384432a0"
    },
    {
      "key": "b279",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1016/S0021-9258(18)48445-1",
      "volume": "267",
      "author": "Wikstrom L",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b280",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.6.7.1165"
    },
    {
      "key": "b281",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.1.12.907"
    },
    {
      "key": "b282",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.2.9.753"
    },
    {
      "key": "b283",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.275.1.521"
    },
    {
      "key": "b284",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.M000567200"
    },
    {
      "key": "b285",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/17.16.4809"
    },
    {
      "key": "b286",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)00133-7"
    },
    {
      "key": "b287",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.50.33741"
    },
    {
      "key": "b288",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/20.1.262"
    },
    {
      "key": "b289",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.33.20800"
    },
    {
      "key": "b290",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0969-2126(99)80112-9"
    },
    {
      "key": "b291",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0896-6273(00)80708-4"
    },
    {
      "key": "b292",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.8.10.1943"
    },
    {
      "key": "b293",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.12.5.1303"
    },
    {
      "key": "b294",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90646-8"
    },
    {
      "key": "b295",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S1097-2765(00)80222-1"
    },
    {
      "key": "b296",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.272.5268.1606"
    },
    {
      "key": "b297",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0968-0004(77)90042-1"
    },
    {
      "key": "b298",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1988.tb03144.x"
    },
    {
      "key": "b299",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb03544.x"
    }
  ],
  "container-title": "Annual Review of Genetics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.annualreviews.org/doi/pdf/10.1146/annurev.genet.35.102401.090313",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        1,
        6
      ]
    ],
    "date-time": "2024-01-06T05:01:25Z",
    "timestamp": 1704517285000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.annualreviews.org/doi/10.1146/annurev.genet.35.102401.090313"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  },
  "references-count": 299,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2001,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.genet.35.102401.090313"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.genet.35.102401.090313",
  "relation": {},
  "ISSN": [
    "0066-4197",
    "1545-2948"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Genet.",
  "published": {
    "date-parts": [
      [
        2001,
        12
      ]
    ]
  }
}