DOI: 10.1146/annurev.genet.34.1.439. GENETIC ANALYSIS OF BACTERIOPHAGE-ENCODED COCHAPERONINS

GENETIC ANALYSIS OF BACTERIOPHAGE-ENCODED COCHAPERONINS

10.1146/annurev.genet.34.1.439

Crossref journal-article

Annual Reviews

Annual Review of Genetics (22)

Abstract

▪ Abstract Early genetic studies identified the Escherichia coli groES and groEL genes because mutations in them blocked the growth of bacteriophages λ and T4. Subsequent genetic and biochemical analyses have shown that GroES and GroEL constitute a chaperonin machine, absolutely essential for E. coli growth, because it is needed for the correct folding of many of its proteins. In spite of very little sequence identity to GroES, the bacteriophage T4-encoded Gp31 protein and the bacteriophage RB49-encoded CocO protein are bona fide GroEL cochaperonins, even capable of substituting for GroES in E. coli growth. A major functional distinction is that only Gp31 and CocO can assist GroEL in the correct folding of Gp23, the major bacteriophage capsid protein. Conserved structural features between CocO and Gp31, which are absent from GroES, highlight their potential importance in specific cochaperonin function.

Bibliography

Ang, D., Keppel, F., Klein, G., Richardson, A., & Georgopoulos, C. (2000). GENETIC ANALYSIS OF BACTERIOPHAGE-ENCODED COCHAPERONINS. Annual Review of Genetics, 34(1), 439â456.

Authors 5

Debbie Ang (first)
France Keppel (additional)
Gracjana Klein (additional)
Alexandra Richardson (additional)
Costa Georgopoulos (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited	3 years, 10 months ago (Oct. 12, 2021, 2:14 a.m.)
Indexed	1 month, 4 weeks ago (July 4, 2025, 7:47 a.m.)
Issued	24 years, 9 months ago (Dec. 1, 2000)
Published	24 years, 9 months ago (Dec. 1, 2000)
Published Print	24 years, 9 months ago (Dec. 1, 2000)

Funders 0

None

BibTeX

@article{Ang_2000, title={GENETIC ANALYSIS OF BACTERIOPHAGE-ENCODED COCHAPERONINS}, volume={34}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.34.1.439}, DOI={10.1146/annurev.genet.34.1.439}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Ang, Debbie and Keppel, France and Klein, Gracjana and Richardson, Alexandra and Georgopoulos, Costa}, year={2000}, month=dec, pages={439–456} }

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