DOI: 10.1146/annurev.genet.33.1.399. Genetics of Chemotaxis and Thermotaxis in the Nematode <i>Caenorhabditis Elegans</i>

Genetics of Chemotaxis and Thermotaxis in the Nematode Caenorhabditis Elegans

10.1146/annurev.genet.33.1.399

Crossref journal-article

Annual Reviews

Annual Review of Genetics (22)

Abstract

▪ Abstract Molecular genetic analysis of chemotaxis and thermotaxis in Caenorhabditis elegans has revealed the molecular bases of olfaction, taste, and thermosensation, which, in turn, has demonstrated that sensory signaling in C. elegans is very similar to that in vertebrates. A cyclic nucleotide-gated channel (TAX-2/TAX-4) that is highly homologous to the olfactory and photoreceptor channels in vertebrates is required for taste and thermosensation, in addition to olfaction. A cation channel (OSM-9) that is closely related to a capsaicin receptor channel is required for olfactory adaptation in one olfactory neuron and olfactory sensation in the other olfactory neuron. A novel Gα protein (ODR-3) is essential for olfactory responses in all olfactory neurons and aversive responses in a polymodal sensory neuron. A G protein–coupled seven-transmembrane receptor (ODR-10) is the first olfactory receptor whose ligand was elucidated. Using chemotaxis and thermotaxis as behavioral paradigms, neural plasticity including learning and memory can be studied genetically in C. elegans.

Bibliography

Mori, I. (1999). Genetics of Chemotaxis and Thermotaxis in the Nematode Caenorhabditis Elegans. Annual Review of Genetics, 33(1), 399â422.

Authors 1

Ikue Mori (first)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:43 a.m.)
Deposited	3 years, 10 months ago (Oct. 12, 2021, 7:23 a.m.)
Indexed	4 days, 5 hours ago (Aug. 22, 2025, 12:45 a.m.)
Issued	25 years, 8 months ago (Dec. 1, 1999)
Published	25 years, 8 months ago (Dec. 1, 1999)
Published Print	25 years, 8 months ago (Dec. 1, 1999)

Funders 0

None

BibTeX

@article{Mori_1999, title={Genetics of Chemotaxis and Thermotaxis in the Nematode Caenorhabditis Elegans}, volume={33}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.33.1.399}, DOI={10.1146/annurev.genet.33.1.399}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Mori, Ikue}, year={1999}, month=dec, pages={399–422} }

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