DOI: 10.1146/annurev.genet.31.1.177. VIRAL TRANSACTIVATING PROTEINS

10.1146/annurev.genet.31.1.177

Crossref journal-article

Annual Reviews

Annual Review of Genetics (22)

Abstract

▪ Abstract Many viruses utilize the cellular transcription apparatus to express their genomes, and they encode transcriptional regulatory proteins that modulate the process. Here we review the current understanding of three viral regulatory proteins. The adenovirus E1A protein acts within the nucleus to regulate transcription through its ability to bind to other proteins. The herpes simplex type 1 virus VP16 protein acts within the nucleus to control transcription by binding to DNA in conjunction with cellular proteins. The human T-cell leukemia virus Tax protein influences transcription through interactions with cellular proteins in the nucleus as well as the cytoplasm.

Bibliography

Flint, J., & Shenk, T. (1997). VIRAL TRANSACTIVATING PROTEINS. Annual Review of Genetics, 31(1), 177â212.

Authors 2

Jane Flint (first)
Thomas Shenk (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited	3 years, 10 months ago (Oct. 12, 2021, 4:04 a.m.)
Indexed	2 months ago (July 2, 2025, 3:07 p.m.)
Issued	27 years, 9 months ago (Dec. 1, 1997)
Published	27 years, 9 months ago (Dec. 1, 1997)
Published Print	27 years, 9 months ago (Dec. 1, 1997)

Funders 0

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BibTeX

@article{Flint_1997, title={VIRAL TRANSACTIVATING PROTEINS}, volume={31}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.31.1.177}, DOI={10.1146/annurev.genet.31.1.177}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Flint, Jane and Shenk, Thomas}, year={1997}, month=dec, pages={177–212} }

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  "abstract": "<jats:p> \u25aa Abstract\u2002 Many viruses utilize the cellular transcription apparatus to express their genomes, and they encode transcriptional regulatory proteins that modulate the process. Here we review the current understanding of three viral regulatory proteins. The adenovirus E1A protein acts within the nucleus to regulate transcription through its ability to bind to other proteins. The herpes simplex type 1 virus VP16 protein acts within the nucleus to control transcription by binding to DNA in conjunction with cellular proteins. The human T-cell leukemia virus Tax protein influences transcription through interactions with cellular proteins in the nucleus as well as the cytoplasm. </jats:p>",
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