DOI: 10.1146/annurev.genet.30.1.529. PARALOGOUS <i>HOX</i> GENES: Function and Regulation

PARALOGOUS HOX GENES: Function and Regulation

10.1146/annurev.genet.30.1.529

Crossref journal-article

Annual Reviews

Annual Review of Genetics (22)

Abstract

▪ Abstract The Hox homeobox gene family plays a pivotal role in regulating patterning and axial morphogenesis in vertebrates. Molecular characterization of the four Hox clusters has shown that they are evolutionarily related with respect to sequence, organization, and expression, suggesting they arose by duplication and divergence. Transgenic analysis has clearly demonstrated the functional roles of individual genes in a broad range of embryonic tissues, and in compound mutants has addressed the issues of cooperativity and redundancy. There is an emerging picture of the cis-regulatory elements underlying Hox expression, and for the 3′ members of the clusters there is a considerable degree of conservation between paralogous genes with respect to their functional roles and regulatory control.

Bibliography

Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996). PARALOGOUS HOX GENES: Function and Regulation. Annual Review of Genetics, 30(1), 529â556.

Authors 4

Mark Maconochie (first)
Stefan Nonchev (additional)
Alastair Morrison (additional)
Robb Krumlauf (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:43 a.m.)
Deposited	3 years, 10 months ago (Oct. 12, 2021, 12:47 a.m.)
Indexed	3 weeks, 2 days ago (Aug. 5, 2025, 9:04 a.m.)
Issued	28 years, 8 months ago (Dec. 1, 1996)
Published	28 years, 8 months ago (Dec. 1, 1996)
Published Print	28 years, 8 months ago (Dec. 1, 1996)

Funders 0

None

BibTeX

@article{Maconochie_1996, title={PARALOGOUS HOX GENES: Function and Regulation}, volume={30}, ISSN={1545-2948}, url={http://dx.doi.org/10.1146/annurev.genet.30.1.529}, DOI={10.1146/annurev.genet.30.1.529}, number={1}, journal={Annual Review of Genetics}, publisher={Annual Reviews}, author={Maconochie, Mark and Nonchev, Stefan and Morrison, Alastair and Krumlauf, Robb}, year={1996}, month=dec, pages={529–556} }

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