DOI: 10.1146/annurev.cellbio.23.090506.123209. The Small G Proteins of the Arf Family and Their Regulators

The Small G Proteins of the Arf Family and Their Regulators

10.1146/annurev.cellbio.23.090506.123209

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

Small G proteins play a central role in the organization of the secretory and endocytic pathways. The majority of such small G proteins are members of the Rab family, which are anchored to the bilayer by C-terminal prenyl groups. However, the recruitment of some effectors, including vesicle coat proteins, is mediated by a second class of small G proteins that is unique in having an N-terminal amphipathic helix that becomes available for membrane insertion upon GTP binding. Sar1, Arf1, and Arf6 are the best-characterized members of this ADP-ribosylation factor (Arf) family. In addition, all eukaryotes contain additional distantly related G proteins, often called Arf like, or Arls. The complete Arf family in humans has 29 members. The roles of these related G proteins are poorly understood, but recent work has shown that some are involved in membrane traffic or organizing the cytoskeleton. Here we review what is known about all the members of the Arf family, along with the known regulatory molecules that convert them between GDP- and GTP-bound states.

Bibliography

Gillingham, A. K., & Munro, S. (2007). The Small G Proteins of the Arf Family and Their Regulators. Annual Review of Cell and Developmental Biology, 23(1), 579â611.

Authors 2

Alison K. Gillingham (first)
Sean Munro (additional)

References 181 Referenced 507

10.1016/S0021-9258(18)37842-6 / J. Biol. Chem. by Achstetter T (1988)
10.1083/jcb.200212142
10.1038/372704a0
10.1074/jbc.M410820200
10.1128/MCB.19.3.2338
10.1016/j.ceb.2006.06.003
10.1016/S1534-5807(02)00146-6
10.1016/S0092-8674(04)00412-X
10.1016/j.bbrc.2006.03.221
10.1242/jcs.02351
10.1074/jbc.M003961200
10.1038/365347a0
10.1074/jbc.M200128200
10.1038/ncb1120
10.1128/JVI.01820-06
10.1083/jcb.149.5.1087
10.1038/nature01040
10.1002/pmic.200300783
10.1016/0167-4781(96)00081-4
10.1128/MCB.18.12.7038
10.1056/NEJMoa042280
10.1016/j.devcel.2007.03.004
10.1091/mbc.E02-10-0693
10.1016/S0014-5793(02)03068-5
10.1038/384481a0
10.1016/S0092-8674(03)00720-7
{'key': 'B27', 'first-page': '71', 'volume': '146', 'author': 'Claude A', 'year': '1999', 'journal-title': 'J. Cell Biol.'} / J. Cell Biol. by Claude A (1999)
10.1091/mbc.E06-11-0998
10.1091/mbc.E03-06-0443
10.1126/science.270.5244.1999
10.1038/nrm1910
10.1038/80924
10.1242/jcs.01497
10.1242/jcs.115.14.2867 / J. Cell Sci. by Derrien V (2002)
10.1074/jbc.R300026200
10.1016/S0955-0674(00)00119-8
10.1016/j.cub.2005.12.032
10.1038/ng1414
10.1210/me.13.4.644
10.1093/emboj/18.6.1480
10.1038/nature05412
10.1016/S0960-9822(03)00089-7
10.1016/S0092-8674(03)00003-5
10.1083/jcb.200407088
10.1016/S0092-8674(00)81754-7
10.1016/S0092-8674(00)80598-X
10.1093/hmg/11.24.3065
10.1105/tpc.12.3.343
10.1074/jbc.271.31.18859
10.1016/j.jmb.2005.05.036
10.1093/emboj/21.9.2095
10.1073/pnas.0604091103
10.1242/jcs.02925
10.1242/jcs.02958
10.1016/j.cub.2007.03.007
10.1016/S0092-8674(00)81540-8
10.1016/S0962-8924(99)01699-2
10.1083/jcb.151.3.627
10.1016/S0968-0004(00)01644-3
10.1016/S0014-5793(99)00759-0
10.1083/jcb.200512057
10.1016/S0021-9258(19)57489-0 / J. Biol. Chem. by Kahn RA (1986)
10.1126/science.1063665
10.1074/jbc.272.9.5421
10.1034/j.1600-0854.2002.30705.x
10.1016/j.sbi.2005.10.015
10.1128/MCB.19.3.2330
10.1126/science.275.5308.1927
10.1074/jbc.M002435200
10.1016/S0014-5793(02)03766-3
10.1091/mbc.E03-09-0683
10.1083/jcb.200301006
10.1111/j.1460-9568.1997.tb01378.x
10.1016/S1097-2765(02)00434-3
10.1016/j.cub.2004.07.058
10.1016/j.str.2005.11.008
10.1074/jbc.274.38.27099
10.1016/j.cell.2005.07.025
10.1016/S0960-9822(02)00779-0
10.1093/nar/gkj118
10.1016/j.devcel.2005.09.012
10.1074/jbc.M002470200
10.1016/S0014-5793(99)01117-5
10.1091/mbc.E02-01-0018
10.1091/mbc.E05-01-0023
10.1074/jbc.M103284200
10.1093/emboj/18.24.6890
10.1073/pnas.96.14.7968
10.1074/jbc.M011577200
10.1007/s10549-006-9180-5
10.1016/S0092-8674(00)81577-9
10.1038/sj.emboj.7601634
10.1021/bi062288w
10.1016/S0021-9258(18)52945-8 / J. Biol. Chem. by Mishima K (1993)
10.1016/S0021-9258(18)67398-3 / J. Biol. Chem. by Misumi Y (1986)
10.1016/S1097-2765(02)00428-8
10.1073/pnas.93.23.12856
10.1016/S1097-2765(03)00475-1
10.1186/1471-2164-6-20
10.1042/BST0330601
{'key': 'B101', 'first-page': '1120', 'author': 'Murphy JA', 'year': '2006', 'journal-title': 'Brain Res.'} / Brain Res. by Murphy JA (2006)
10.1126/science.1067025
10.1083/jcb.109.6.2677
10.1091/mbc.E04-02-0151
10.1091/mbc.E05-10-0909
10.1002/(SICI)1097-0134(199702)27:2<204::AID-PROT6>3.0.CO;2-F
10.1242/jcs.111.20.3081 / J. Cell Sci. by Nickel W (1998)
10.1016/S1534-5807(03)00234-X
10.1242/jcs.02486
10.1016/j.cub.2005.11.069
10.1242/jcs.02924
10.1074/jbc.M202969200
10.1038/ncb1234
10.1126/science.1113398
10.1242/dev.01147
10.1016/S1097-2765(03)00356-3
10.1016/S0960-9822(03)00091-5
10.1093/embo-reports/kvf221
10.1126/science.1092586
10.1016/S1097-2765(00)80455-4
10.1242/jcs.114.12.2241 / J. Cell Sci. by Peyroche A (2001)
10.1038/384479a0
10.1093/emboj/18.3.555
10.1083/jcb.200108075
10.1016/S0014-5793(02)03410-5
10.1073/pnas.95.24.14082
10.1083/jcb.200112092
10.1038/nature02197
10.1016/j.jmb.2004.01.052
10.1016/j.ceb.2006.08.002
10.1074/jbc.M413415200
10.1016/j.exppara.2004.07.010
10.1101/gad.1149704
10.1016/j.cub.2005.08.052
10.1038/nsmb893
10.1083/jcb.134.2.279
10.1093/oxfordjournals.jbchem.a022082
10.2353/ajpath.2006.050941
10.1128/MCB.22.8.2761-2768.2002
10.1016/S0378-1119(03)00584-5
10.1038/ncb1121
10.1091/mbc.01-05-0245
10.1038/ng1276
10.1073/pnas.0510599103
10.1038/nsb920
10.1242/jcs.02524
10.1091/mbc.E04-05-0388
10.1016/j.tibs.2004.08.007
10.1074/jbc.M112427200
10.1111/j.1600-0854.2006.00480.x
10.1097/00041433-200404000-00012
10.1105/tpc.105.039008
10.1073/pnas.051634798
10.1042/BJ20060555
10.1101/gad.221702
10.1128/MCB.00298-06
10.1074/jbc.M003171200
10.1091/mbc.E04-08-0683
10.1111/j.1432-1033.1997.00512.x
10.1074/jbc.274.18.12308
10.1038/sj.emboj.7601007
10.1084/jem.193.8.955
10.1074/jbc.M102359200
10.1074/jbc.C300482200
10.1126/science.1062023
10.1128/MCB.20.19.7342-7352.2000
10.1091/mbc.E04-12-1042
10.1083/jcb.200605106
10.1111/j.1600-0854.2004.00158.x
10.1034/j.1600-0854.2003.40202.x
10.1242/jcs.01660
10.1128/JVI.01225-06
10.1078/0171-9335-00242
10.1038/nsmb714
10.1128/MCB.23.7.2476-2488.2003
10.1073/pnas.0409871102
10.1016/S0092-8674(00)00195-1
10.1242/jcs.03237
10.1080/09687860600840100
10.1242/jcs.03173
10.1091/mbc.01-08-0420

Dates

Type	When
Created	18 years, 1 month ago (July 10, 2007, 2:04 p.m.)
Deposited	3 years, 10 months ago (Oct. 7, 2021, 11:53 p.m.)
Indexed	5 days, 21 hours ago (Aug. 21, 2025, 1:28 p.m.)
Issued	17 years, 9 months ago (Nov. 1, 2007)
Published	17 years, 9 months ago (Nov. 1, 2007)
Published Print	17 years, 9 months ago (Nov. 1, 2007)

Funders 0

None

BibTeX

@article{Gillingham_2007, title={The Small G Proteins of the Arf Family and Their Regulators}, volume={23}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.23.090506.123209}, DOI={10.1146/annurev.cellbio.23.090506.123209}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Gillingham, Alison K. and Munro, Sean}, year={2007}, month=nov, pages={579–611} }

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