DOI: 10.1146/annurev.cellbio.20.012103.135836. REGULATION OF MUSCLE MASS BY MYOSTATIN

10.1146/annurev.cellbio.20.012103.135836

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle mass. During embryogenesis, myostatin is expressed by cells in the myotome and in developing skeletal muscle and acts to regulate the final number of muscle fibers that are formed. During adult life, myostatin protein is produced by skeletal muscle, circulates in the blood, and acts to limit muscle fiber growth. The existence of circulating tissue-specific growth inhibitors of this type was hypothesized over 40 years ago to explain how sizes of individual tissues are controlled. Skeletal muscle appears to be the first example of a tissue whose size is controlled by this type of regulatory mechanism, and myostatin appears to be the first example of the long-sought chalone.

Bibliography

Lee, S.-J. (2004). REGULATION OF MUSCLE MASS BY MYOSTATIN. Annual Review of Cell and Developmental Biology, 20(1), 61â86.

Authors 1

Se-Jin Lee (first)

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Dates

Type	When
Created	20 years, 10 months ago (Oct. 8, 2004, 5:10 p.m.)
Deposited	3 years, 10 months ago (Oct. 8, 2021, 1:14 a.m.)
Indexed	1 hour, 5 minutes ago (Sept. 2, 2025, 10:31 p.m.)
Issued	20 years, 10 months ago (Nov. 1, 2004)
Published	20 years, 10 months ago (Nov. 1, 2004)
Published Print	20 years, 10 months ago (Nov. 1, 2004)

Funders 0

None

BibTeX

@article{Lee_2004, title={REGULATION OF MUSCLE MASS BY MYOSTATIN}, volume={20}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.20.012103.135836}, DOI={10.1146/annurev.cellbio.20.012103.135836}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Lee, Se-Jin}, year={2004}, month=nov, pages={61–86} }

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