DOI: 10.1146/annurev.cellbio.19.111301.112449. The COP9 Signalosome

The COP9 Signalosome

10.1146/annurev.cellbio.19.111301.112449

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

▪ Abstract The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin-like protein, Nedd8/Rub1, from the cullin component of SCF ubiquitin E3 ligase (i.e., de-neddylation). In addition, CSN is associated with de-ubiquitination activity and protein kinase activities capable of phosphorylating important signaling regulators. The involvement of CSN in a number of cellular and developmental processes has been attributed to its control over ubiquitin-proteasome-mediated protein degradation.

Bibliography

Wei, N., & Deng, X. W. (2003). The COP9 Signalosome. Annual Review of Cell and Developmental Biology, 19(1), 261â286.

Authors 2

Ning Wei (first)
Xing Wang Deng (additional)

References 129 Referenced 402

Dates

Type	When
Created	21 years, 10 months ago (Oct. 21, 2003, 3:51 p.m.)
Deposited	3 years, 10 months ago (Oct. 8, 2021, 1:29 a.m.)
Indexed	12 hours, 23 minutes ago (Sept. 3, 2025, 6:34 a.m.)
Issued	21 years, 10 months ago (Nov. 1, 2003)
Published	21 years, 10 months ago (Nov. 1, 2003)
Published Print	21 years, 10 months ago (Nov. 1, 2003)

Funders 0

None

BibTeX

@article{Wei_2003, title={The COP9 Signalosome}, volume={19}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.19.111301.112449}, DOI={10.1146/annurev.cellbio.19.111301.112449}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Wei, Ning and Deng, Xing Wang}, year={2003}, month=nov, pages={261–286} }

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  "abstract": "<jats:p> \u25aa Abstract\u2002 The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin-like protein, Nedd8/Rub1, from the cullin component of SCF ubiquitin E3 ligase (i.e., de-neddylation). In addition, CSN is associated with de-ubiquitination activity and protein kinase activities capable of phosphorylating important signaling regulators. The involvement of CSN in a number of cellular and developmental processes has been attributed to its control over ubiquitin-proteasome-mediated protein degradation. </jats:p>",
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