DOI: 10.1146/annurev.cellbio.18.011402.160624. Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

10.1146/annurev.cellbio.18.011402.160624

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

▪ Abstract Cells monitor the physiological load placed on their endoplasmic reticulum (ER) and respond to perturbations in ER function by a process known as the unfolded protein response (UPR). In metazoans the UPR has a transcriptional component that up-regulates expression of genes that enhance the capacity of the organelle to deal with the load of client proteins and a translational component that insures tight coupling between protein biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding.

Bibliography

Harding, H. P., Calfon, M., Urano, F., Novoa, I., & Ron, D. (2002). Transcriptional and Translational Control in the Mammalian Unfolded Protein Response. Annual Review of Cell and Developmental Biology, 18(1), 575â599.

Authors 5

Heather P. Harding (first)
Marcella Calfon (additional)
Fumihiko Urano (additional)
Isabel Novoa (additional)
David Ron (additional)

References 95 Referenced 766

10.1242/jcs.114.17.3207 / J. Cell Sci. by Bertolotti A (2001)
10.1172/JCI11476
10.1038/35014014
10.1016/0014-5793(93)81701-Z
10.1016/S0079-6603(08)60034-3
10.1016/S0092-8674(00)80675-3
10.1038/415092a
10.1016/S1097-2765(00)80251-8
10.1016/S0960-9822(06)00373-3
10.1083/jcb.105.4.1515
10.1002/aja.1001970207
10.1091/mbc.8.9.1805
10.1016/0092-8674(93)90648-A
10.1016/S0092-8674(00)81360-4
10.1074/jbc.272.20.13203
10.1038/78085
10.1017/S1355838201002230
10.1093/nar/27.2.439
10.1002/j.1460-2075.1992.tb05201.x
10.1006/biol.1994.1016
10.1042/0264-6021:3390135
10.1101/gad.6.8.1402
10.1016/0092-8674(83)90474-9
10.1016/S0962-8924(00)01745-1
10.1093/emboj/18.11.3119
10.1146/annurev.cellbio.18.032002.131219
10.1093/emboj/20.23.6909
10.1016/S1097-2765(00)00108-8
10.1016/S1097-2765(01)00264-7
10.1016/S1097-2765(00)80330-5
10.1038/16729
10.1101/sqb.2001.66.499
10.1091/mbc.10.11.3787
10.1073/pnas.94.3.843
10.1074/jbc.273.33.20737
10.1128/MCB.8.10.4250
Hinnebusch A. 1996. Translational control ofGCN4: gene-specific regulation by phosphorylation of eIF2. InTranslational Control, ed. J Hershey, M Mathews, N Sonenberg, pp. 199–244. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
10.1074/jbc.272.35.21661
Hinnebusch AG. 2000.Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes.InTranslational Control of Gene Expression, ed. N Sonenberg, JWB Hershey, MB Mathews, pp. 185–243. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
10.1101/gad.13.10.1211
10.1091/mbc.8.10.1845
10.1074/jbc.273.3.1802
10.1128/MCB.13.2.877
10.1242/jcs.1989.Supplement_11.10
10.1038/332462a0
10.1074/jbc.274.1.486
10.1128/MCB.14.8.5533
{'key': 'b48', 'first-page': '44881', 'volume': '275', 'author': 'Liu CY', 'year': '2000', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Liu CY (2000)
10.1159/000468767
10.1006/bbrc.1999.0972
10.1016/S0092-8674(00)80855-7
10.1046/j.1365-2443.1996.d01-274.x
10.1016/0092-8674(93)90521-Q
10.1073/pnas.050010197
10.1002/j.1460-2075.1992.tb05323.x
10.1038/47513
10.1111/j.1365-2958.1992.tb00864.x
10.1016/0022-2836(81)90212-6
10.1016/S0092-8674(00)81667-0
10.1083/jcb.153.5.1011
10.1006/bbrc.2000.3987
10.1128/MCB.21.9.3220-3233.2001
10.1016/S0955-0674(00)00219-2
10.1101/gad.14.2.152 / Genes Dev. by Reimold AM (2000)
10.1038/35085509
10.1093/nar/27.6.1437
10.1016/S0092-8674(01)00505-0
10.1038/35046500
10.1016/S1097-2765(01)00265-9
10.1002/j.1460-2075.1996.tb00666.x
10.1016/S0092-8674(01)00612-2
10.1074/jbc.274.9.5723
10.1128/MCB.18.12.7499
10.1016/S0092-8674(00)81361-6
10.1016/S0092-8674(00)80369-4
10.1074/jbc.274.5.2637
10.1111/j.1399-0004.1996.tb03275.x
10.1083/jcb.152.5.997
10.1080/107710497174778
10.2337/diabetes.46.11.1733
10.1101/gad.839400
10.1101/gad.12.12.1812
10.1016/S0092-8674(00)80835-1
10.1126/science.287.5453.664
10.1093/emboj/17.19.5708
10.1128/MCB.18.4.1967
10.1074/jbc.275.5.3377
10.1016/S0022-3476(72)80596-1
10.1016/S1097-2765(00)00133-7
10.1074/jbc.M010677200
10.1074/jbc.273.50.33741
10.1016/S0092-8674(01)00611-0
10.1128/MCB.20.18.6755-6767.2000
10.1128/MCB.21.4.1239-1248.2001
10.1128/MCB.22.11.3864-3874.2002

Dates

Type	When
Created	22 years, 10 months ago (Oct. 7, 2002, 5:08 p.m.)
Deposited	2 years, 3 months ago (April 24, 2023, 4:31 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 2, 2025, 12:23 a.m.)
Issued	22 years, 9 months ago (Nov. 1, 2002)
Published	22 years, 9 months ago (Nov. 1, 2002)
Published Print	22 years, 9 months ago (Nov. 1, 2002)

Funders 0

None

BibTeX

@article{Harding_2002, title={Transcriptional and Translational Control in the Mammalian Unfolded Protein Response}, volume={18}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.18.011402.160624}, DOI={10.1146/annurev.cellbio.18.011402.160624}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Harding, Heather P. and Calfon, Marcella and Urano, Fumihiko and Novoa, Isabel and Ron, David}, year={2002}, month=nov, pages={575–599} }

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