DOI: 10.1146/annurev.cellbio.16.1.591. SUMO

10.1146/annurev.cellbio.16.1.591

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

▪ Abstract SUMO (small ubiquitin-related modifier) is the best-characterized member of a growing family of ubiquitin-related proteins. It resembles ubiquitin in its structure, its ability to be ligated to other proteins, as well as in the mechanism of ligation. However, in contrast to ubiquitination—often the first step on a one-way road to protein degradation—SUMOlation does not seem to mark proteins for degradation. In fact, SUMO may even function as an antagonist of ubiquitin in the degradation of selected proteins. While most SUMO targets are still at large, available data provide compelling evidence for a role of SUMO in the regulation of protein-protein interactions and/or subcellular localization.

Bibliography

Melchior, F. (2000). SUMOâNonclassical Ubiquitin. Annual Review of Cell and Developmental Biology, 16(1), 591â626.

Authors 1

Frauke Melchior (first)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:40 a.m.)
Deposited	1 year, 7 months ago (Jan. 5, 2024, 11:11 p.m.)
Indexed	2 weeks, 2 days ago (Aug. 7, 2025, 4:52 a.m.)
Issued	24 years, 9 months ago (Nov. 1, 2000)
Published	24 years, 9 months ago (Nov. 1, 2000)
Published Print	24 years, 9 months ago (Nov. 1, 2000)

Funders 0

None

BibTeX

@article{Melchior_2000, title={SUMO—Nonclassical Ubiquitin}, volume={16}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.16.1.591}, DOI={10.1146/annurev.cellbio.16.1.591}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Melchior, Frauke}, year={2000}, month=nov, pages={591–626} }

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