DOI: 10.1146/annurev.cellbio.14.1.111. FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

10.1146/annurev.cellbio.14.1.111

Crossref journal-article

Annual Reviews

Annual Review of Cell and Developmental Biology (22)

Abstract

▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be isolated from cells suggest that biological membranes are not always in a liquid-crystalline phase. Instead, sphingolipid and cholesterol-rich membranes such as plasma membranes appear to exist, at least partially, in the liquid-ordered phase or a phase with similar properties. Sphingolipid and cholesterol-rich domains may exist as phase-separated “rafts” in the membrane. We discuss the relationship between detergent-resistant membranes, rafts, caveolae, and low-density plasma membrane fragments. We also discuss possible functions of lipid rafts in membranes. Signal transduction through the high-affinity receptor for IgE on basophils, and possibly through related receptors on other hematopoietic cells, appears to be enhanced by association with rafts. Raft association may also aid in signaling through proteins anchored by glycosylphosphatidylinositol, particularly in hematopoietic cells and neurons. Rafts may also function in sorting and trafficking through the secretory and endocytic pathways.

Bibliography

Brown, D. A., & London, E. (1998). FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES. Annual Review of Cell and Developmental Biology, 14(1), 111â136.

Authors 2

D. A. Brown (first)
E. London (additional)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:49 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 3:40 p.m.)
Indexed	5 days, 21 hours ago (Aug. 19, 2025, 7:04 a.m.)
Issued	26 years, 9 months ago (Nov. 1, 1998)
Published	26 years, 9 months ago (Nov. 1, 1998)
Published Print	26 years, 9 months ago (Nov. 1, 1998)

Funders 0

None

BibTeX

@article{Brown_1998, title={FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES}, volume={14}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.14.1.111}, DOI={10.1146/annurev.cellbio.14.1.111}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Brown, D. A. and London, E.}, year={1998}, month=nov, pages={111–136} }

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