AH RECEPTOR SIGNALING PATHWAYS
10.1146/annurev.cellbio.12.1.55
Crossref journal-article
Annual Reviews
Annual Review of Cell and Developmental Biology (22)
Abstract

▪ Abstract  The aryl hydrocarbon (Ah) receptor has occupied the attention of toxicologists for over two decades. Interest arose from the early observation that this soluble protein played key roles in the adaptive metabolic response to polycyclic aromatic hydrocarbons and in the toxic mechanism of halogenated dioxins and dibenzofurans. More recent investigations have provided a fairly clear picture of the primary adaptive signaling pathway, from agonist binding to the transcriptional activation of genes involved in the metabolism of xenobiotics. Structure-activity studies have provided an understanding of the pharmacology of this receptor; recombinant DNA approaches have identified the enhancer sequences through which this factor regulates gene expression; and functional analysis of cloned cDNAs has allowed the characterization of the major signaling components in this pathway. Our objective is to review the Ah receptor's role in regulation of xenobiotic metabolism and use this model as a framework for understanding the less well-characterized mechanism of dioxin toxicity. In addition, it is hoped that this information can serve as a model for future efforts to understand an emerging superfamily of related signaling pathways that control biological responses to an array of environmental stimuli.

Bibliography

Schmidt, J. V., & Bradfield, C. A. (1996). AH RECEPTOR SIGNALING PATHWAYS. Annual Review of Cell and Developmental Biology, 12(1), 55–89.

Authors 2
  1. Jennifer V. Schmidt (first)
  2. Christopher A. Bradfield (additional)
References 142 Referenced 729
  1. 10.1016/0041-008X(89)90010-0
  2. 10.1016/0041-008X(90)90337-T
  3. 10.1002/aja.1002040204
  4. 10.1002/aja.1002040205
  5. 10.1128/MCB.15.2.756
  6. 10.1016/S0021-9258(18)31421-2 / J. Biol. Chem. by Asman DC (1993)
  7. {'key': 'b7', 'first-page': '432', 'volume': '47', 'author': 'Bacsi SG', 'year': '1995', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Bacsi SG (1995)
  8. 10.1016/0092-8674(90)90214-Y
  9. {'key': 'b9', 'first-page': '229', 'volume': '34', 'author': 'Bradfield CA', 'year': '1988', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Bradfield CA (1988)
  10. 10.1016/0092-8674(92)90507-9
  11. {'key': 'b11', 'first-page': 'A132', 'volume': '45', 'author': 'Brooks B', 'year': '1989', 'journal-title': 'Am. J. Hum. Genet.'} / Am. J. Hum. Genet. by Brooks B (1989)
  12. 10.1073/pnas.89.17.8185
  13. 10.1093/nar/22.15.3038
  14. 10.1016/S0021-9258(18)43782-9 / J. Biol. Chem. by Carver LA (1994)
  15. 10.1038/ng0595-9
  16. 10.1126/science.8392225
  17. 10.1016/S0021-9258(18)92861-9 / J. Biol. Chem. by Choi EJ (1991)
  18. 10.1038/326042a0
  19. 10.3181/00379727-168-41275
  20. {'key': 'b20', 'first-page': '450', 'volume': '16', 'author': 'Conney AH', 'year': '1956', 'journal-title': 'Cancer Res.'} / Cancer Res. by Conney AH (1956)
  21. 10.1016/0041-008X(71)90282-1
  22. 10.1002/tera.1420420606
  23. 10.1016/0092-8674(88)90538-7
  24. 10.1073/pnas.92.20.9191
  25. 10.1073/pnas.89.2.599
  26. 10.1016/0041-008X(88)90344-4
  27. 10.1016/0162-3109(91)90023-R
  28. 10.1016/0092-8674(90)90088-V
  29. 10.1016/S0006-291X(88)80566-7
  30. 10.1016/S0021-9258(19)77819-3 / J. Biol. Chem. by Denison MS (1988)
  31. 10.1073/pnas.85.8.2528
  32. {'key': 'b32', 'first-page': '911', 'volume': '44', 'author': 'Dolwick KM', 'year': '1993', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Dolwick KM (1993)
  33. 10.1073/pnas.90.18.8566
  34. 10.1016/S0021-9258(17)30561-6 / J. Biol. Chem. by Elferink CJ (1990)
  35. 10.1101/gad.8.8.970
  36. 10.1016/S0021-9258(18)46990-6 / J. Biol. Chem. by Ema M (1994)
  37. 10.1016/0006-291X(92)91185-S
  38. {'key': 'b38', 'first-page': '8', 'volume': '91', 'author': 'Eppig JT', 'year': '1993', 'journal-title': 'Mouse Genome'} / Mouse Genome by Eppig JT (1993)
  39. 10.1016/S0021-9258(20)64358-7 / J. Biol. Chem. by Favreau LV (1991)
  40. 10.1126/science.7732381
  41. 10.1016/S0012-1606(89)80017-X
  42. 10.1016/0925-4773(94)90013-2
  43. 10.1073/pnas.85.16.5859
  44. 10.1021/bi00225a026
  45. 10.1016/0041-008X(81)90459-2
  46. 10.1126/science.270.5237.811
  47. 10.1016/0273-2300(92)90036-9
  48. 10.1007/BF00486072
  49. 10.1016/0041-008X(85)90373-4
  50. 10.1038/373360a0
  51. 10.1126/science.1852076
  52. 10.1016/0162-3109(86)90001-9
  53. 10.1016/0041-008X(86)90227-9
  54. 10.1126/science.7855598
  55. 10.1038/364259a0
  56. 10.1146/annurev.pa.34.040194.002015
  57. 10.1101/gad.10.1.103
  58. 10.1016/S0021-9258(18)31725-3 / J. Biol. Chem. by Jain S (1994)
  59. 10.1016/S0021-9258(17)36651-6 / J. Biol. Chem. by Jaiswal AK (1994)
  60. 10.1128/MCB.10.10.5098
  61. 10.1016/S0021-9258(19)62665-7 / J. Biol. Chem. by Jones PBC (1986)
  62. 10.1038/ng1295-415
  63. {'key': 'b63', 'first-page': '49', 'volume': '4', 'author': 'Kadesch T', 'year': '1993', 'journal-title': 'Cell Growth Diff.'} / Cell Growth Diff. by Kadesch T (1993)
  64. 10.1016/0041-008X(90)90356-Y
  65. 10.1128/MCB.13.6.3782
  66. 10.1016/0041-008X(78)90075-3
  67. 10.1126/science.3289117
  68. 10.1016/S0021-9258(18)46900-1 / J. Biol. Chem. by Li H (1994)
  69. 10.4049/jimmunol.140.3.928 / J. Immunol. by Luster MI (1988)
  70. 10.1074/jbc.270.21.12697
  71. 10.1016/0092-8674(95)90199-X
  72. 10.1016/S0021-9258(17)41799-6 / J. Biol. Chem. by Mason GG (1994)
  73. 10.1016/S0021-9258(19)36885-1 / J. Biol. Chem. by Matsushita N (1993)
  74. 10.1074/jbc.270.52.31353
  75. 10.1128/MCB.14.4.2438
  76. 10.1016/0092-8674(89)90918-5
  77. 10.1016/0092-8674(89)90682-X
  78. 10.1016/0092-8674(89)90434-0
  79. 10.1016/0041-008X(84)90261-8
  80. 10.1016/0378-1119(96)00060-1
  81. 10.1016/0092-8674(90)90288-P
  82. 10.1016/0092-8674(91)90292-7
  83. 10.1016/0003-9861(69)90253-7
  84. {'key': 'b84', 'first-page': '823', 'volume': '35', 'author': 'Okey AB', 'year': '1989', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Okey AB (1989)
  85. 10.1128/MCB.15.7.3714
  86. 10.1101/gad.4.9.1454
  87. 10.1128/MCB.10.5.1841
  88. 10.1016/S0021-9258(18)68314-0 / J. Biol. Chem. by Perdew GH (1988)
  89. {'key': 'b89', 'first-page': '3616', 'volume': '40', 'author': 'Pitot HC', 'year': '1980', 'journal-title': 'Cancer Res.'} / Cancer Res. by Pitot HC (1980)
  90. {'key': 'b90', 'first-page': '483', 'volume': '46', 'author': 'Pohjanvirta R', 'year': '1994', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. by Pohjanvirta R (1994)
  91. {'key': 'b91', 'first-page': '389', 'volume': '11', 'author': 'Poland A', 'year': '1975', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Poland A (1975)
  92. {'key': 'b92', 'first-page': '3341', 'volume': '39', 'author': 'Poland A', 'year': '1979', 'journal-title': 'Cancer Res.'} / Cancer Res. by Poland A (1979)
  93. {'key': 'b93', 'first-page': '86', 'volume': '17', 'author': 'Poland A', 'year': '1980', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Poland A (1980)
  94. 10.1016/0006-291X(87)90811-4
  95. {'key': 'b95', 'first-page': '306', 'volume': '38', 'author': 'Poland A', 'year': '1990', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Poland A (1990)
  96. 10.1016/S0021-9258(19)84570-2 / J. Biol. Chem. by Poland A (1986)
  97. 10.1016/S0021-9258(17)33205-2 / J. Biol. Chem. by Poland A (1976)
  98. 10.1016/S0021-9258(20)79769-3 / J. Biol. Chem. by Poland A (1974)
  99. {'key': 'b99', 'first-page': '471', 'volume': '32', 'author': 'Poland A', 'year': '1987', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Poland A (1987)
  100. 10.1146/annurev.pa.22.040182.002505
  101. {'key': 'b101', 'first-page': '915', 'volume': '46', 'author': 'Poland A', 'year': '1994', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Poland A (1994)
  102. {'key': 'b102', 'first-page': '428', 'volume': '45', 'author': 'Pollenz RS', 'year': '1994', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Pollenz RS (1994)
  103. 10.1016/S0021-9258(18)42274-0 / J. Biol. Chem. by Pongratz I (1992)
  104. 10.1016/0165-6147(83)90343-7
  105. 10.1002/tcm.1770040505
  106. 10.1038/ng1295-409
  107. 10.1016/S0021-9258(17)37466-5 / J. Biol. Chem. by Quattrochi LC (1994)
  108. 10.1128/MCB.14.9.6075
  109. 10.1126/science.256.5060.1193
  110. 10.1016/0092-8674(92)90508-A
  111. 10.1101/gad.2.9.1144
  112. 10.1016/S0021-9258(20)80668-1 / J. Biol. Chem. by Schmidt JV (1993)
  113. 10.1073/pnas.93.13.6731
  114. 10.1016/S0889-8588(18)30134-5
  115. 10.1073/pnas.88.13.5680
  116. 10.1128/MCB.12.12.5447
  117. 10.1177/096032718900800301
  118. 10.1016/0163-7258(79)90030-5
  119. 10.1073/pnas.92.6.1936
  120. 10.1016/S0021-9258(18)53440-2 / J. Biol. Chem. by Staudinger J (1993)
  121. 10.1016/0092-8674(95)90500-6
  122. 10.1016/0092-8674(91)90653-G
  123. 10.1126/science.1925598
  124. 10.1016/S0021-9258(17)36803-5 / J. Biol. Chem. by Sutter TR (1994)
  125. 10.1097/00008571-199310000-00001
  126. 10.1074/jbc.270.44.26292
  127. 10.1007/BF00486177
  128. {'key': 'b128', 'first-page': '372', 'volume': '29', 'author': 'Tucker AN', 'year': '1986', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. by Tucker AN (1986)
  129. 10.1126/science.2494701
  130. {'key': 'b130', 'first-page': '62', 'volume': '54', 'author': 'Vanden Heuvel JP', 'year': '1994', 'journal-title': 'Cancer Res.'} / Cancer Res. by Vanden Heuvel JP (1994)
  131. 10.1016/0041-008X(83)90288-0
  132. 10.1073/pnas.92.12.5510
  133. 10.1073/pnas.90.9.4304
  134. 10.1074/jbc.270.3.1230
  135. 10.1126/science.1846704
  136. 10.1242/dev.120.12.3563 / Development by Wharton K (1994)
  137. 10.1128/MCB.13.4.2504
  138. 10.1128/MCB.14.12.8343
  139. 10.1073/pnas.92.10.4437
  140. 10.1002/j.1460-2075.1990.tb08081.x
  141. 10.1101/gad.10.1.93
  142. 10.1073/pnas.89.11.4811
Dates
Type When
Created 23 years, 1 month ago (July 27, 2002, 7:49 a.m.)
Deposited 2 years, 4 months ago (April 23, 2023, 3:40 p.m.)
Indexed 10 minutes ago (Sept. 7, 2025, 8:53 a.m.)
Issued 28 years, 10 months ago (Nov. 1, 1996)
Published 28 years, 10 months ago (Nov. 1, 1996)
Published Print 28 years, 10 months ago (Nov. 1, 1996)
Funders 0

None

@article{Schmidt_1996, title={AH RECEPTOR SIGNALING PATHWAYS}, volume={12}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cellbio.12.1.55}, DOI={10.1146/annurev.cellbio.12.1.55}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Schmidt, Jennifer V. and Bradfield, Christopher A.}, year={1996}, month=nov, pages={55–89} }