10.1146/annurev.cb.11.110195.000445
Crossref journal-article
Annual Reviews
Annual Review of Cell and Developmental Biology (22)
Abstract

Induction by fibroblast growth factors of mesoderm during gastrulation leads to blood-forming tissue, including angioblasts and hemopoietic cells, that together constitute the blood islands of the yolk sac. The differentiation of angioblasts from mesoderm and the formation of primitive blood vessels from angioblasts at or near the site of their origin are the two distinct steps during the onset of vascularization that are defined as vasculogenesis. Vascular endothelial growth factor and its high-affinity receptor tyrosine kinase flk-1 represent a paracrine signaling system crucial for the differentiation of endothelial cells and the development of the vascular system. Specific cell adhesion molecules such as VE-cadherin and PECAM-1 (CD-31), and transcription factors such as ets-1, as well as mechanical forces and vascular regression and remodeling are involved in the subsequent events of endothelial cell differentiation, apoptosis, and angiogenesis.

Bibliography

Risau, W., & Flamme, I. (1995). Vasculogenesis. Annual Review of Cell and Developmental Biology, 11(1), 73–91.

Authors 2
  1. Werner Risau (first)
  2. Ingo Flamme (additional)
References 0 Referenced 1,310

None

Dates
Type When
Created 22 years, 1 month ago (July 2, 2003, 2:07 a.m.)
Deposited 3 years, 10 months ago (Oct. 8, 2021, 12:12 a.m.)
Indexed 2 weeks, 2 days ago (Aug. 7, 2025, 4:52 a.m.)
Issued 29 years, 9 months ago (Nov. 1, 1995)
Published 29 years, 9 months ago (Nov. 1, 1995)
Published Print 29 years, 9 months ago (Nov. 1, 1995)
Funders 0

None

@article{Risau_1995, title={Vasculogenesis}, volume={11}, ISSN={1530-8995}, url={http://dx.doi.org/10.1146/annurev.cb.11.110195.000445}, DOI={10.1146/annurev.cb.11.110195.000445}, number={1}, journal={Annual Review of Cell and Developmental Biology}, publisher={Annual Reviews}, author={Risau, Werner and Flamme, Ingo}, year={1995}, month=nov, pages={73–91} }