DOI: 10.1146/annurev.biophys.37.032807.130008. Structure of Eukaryotic RNA Polymerases

10.1146/annurev.biophys.37.032807.130008

Crossref journal-article

Annual Reviews

Annual Review of Biophysics (22)

Abstract

The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzymes. Most structural data have been accumulated for Pol II and its functional complexes. These studies have provided insights into many aspects of the transcription mechanism, including initiation at promoter DNA, elongation of the mRNA chain, tunability of the polymerase active site, which supports RNA synthesis and cleavage, and the response of Pol II to DNA lesions. Detailed structural studies of Pol I and Pol III were reported recently and showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.

Bibliography

Cramer, P., Armache, K.-J., Baumli, S., Benkert, S., Brueckner, F., Buchen, C., Damsma, G. E., Dengl, S., Geiger, S. R., Jasiak, A. J., Jawhari, A., Jennebach, S., Kamenski, T., Kettenberger, H., Kuhn, C.-D., Lehmann, E., Leike, K., Sydow, J. F., & Vannini, A. (2008). Structure of Eukaryotic RNA Polymerases. Annual Review of Biophysics, 37(1), 337â352.

Authors 19

P. Cramer (first)
K.-J. Armache (additional)
S. Baumli (additional)
S. Benkert (additional)
F. Brueckner (additional)
C. Buchen (additional)
G.E. Damsma (additional)
S. Dengl (additional)
S.R. Geiger (additional)
A.J. Jasiak (additional)
A. Jawhari (additional)
S. Jennebach (additional)
T. Kamenski (additional)
H. Kettenberger (additional)
C.-D. Kuhn (additional)
E. Lehmann (additional)
K. Leike (additional)
J.F. Sydow (additional)
A. Vannini (additional)

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Dates

Type	When
Created	17 years, 6 months ago (Feb. 7, 2008, 1:04 p.m.)
Deposited	2 years, 3 months ago (May 16, 2023, 7:49 a.m.)
Indexed	4 days, 21 hours ago (Aug. 20, 2025, 9:19 a.m.)
Issued	17 years, 2 months ago (June 1, 2008)
Published	17 years, 2 months ago (June 1, 2008)
Published Print	17 years, 2 months ago (June 1, 2008)

Funders 0

None

BibTeX

@article{Cramer_2008, title={Structure of Eukaryotic RNA Polymerases}, volume={37}, ISSN={1936-1238}, url={http://dx.doi.org/10.1146/annurev.biophys.37.032807.130008}, DOI={10.1146/annurev.biophys.37.032807.130008}, number={1}, journal={Annual Review of Biophysics}, publisher={Annual Reviews}, author={Cramer, P. and Armache, K.-J. and Baumli, S. and Benkert, S. and Brueckner, F. and Buchen, C. and Damsma, G.E. and Dengl, S. and Geiger, S.R. and Jasiak, A.J. and Jawhari, A. and Jennebach, S. and Kamenski, T. and Kettenberger, H. and Kuhn, C.-D. and Lehmann, E. and Leike, K. and Sydow, J.F. and Vannini, A.}, year={2008}, month=jun, pages={337–352} }

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