DOI: 10.1146/annurev.biophys.35.040405.101950. RIBOSOME DYNAMICS: Insights from Atomic Structure Modeling into Cryo-Electron Microscopy Maps

RIBOSOME DYNAMICS: Insights from Atomic Structure Modeling into Cryo-Electron Microscopy Maps

10.1146/annurev.biophys.35.040405.101950

Crossref journal-article

Annual Reviews

Annual Review of Biophysics and Biomolecular Structure (22)

Abstract

Single-particle cryo-electron microscopy (cryo-EM) is the method of choice for studying the dynamics of macromolecular machines both at a phenomenological and, increasingly, at the molecular level, with the advent of high-resolution component X-ray structures and of progressively improving fitting algorithms. Cryo-EM has shed light on the structure of the ribosome during the four steps of translation: initiation, elongation, termination, and recycling. Interpretation of cryo-EM reconstructions of the ribosome in quasi-atomic detail reveals a picture in which the ribosome uses RNA not only to catalyze chemical reactions, but also as a means for signal transduction over large distances.

Bibliography

Mitra, K., & Frank, J. (2006). RIBOSOME DYNAMICS: Insights from Atomic Structure Modeling into Cryo-Electron Microscopy Maps. Annual Review of Biophysics and Biomolecular Structure, 35(1), 299â317.

Authors 2

Kakoli Mitra (first)
Joachim Frank (additional)

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Dates

Type	When
Created	19 years, 4 months ago (April 7, 2006, 10:20 a.m.)
Deposited	3 years, 10 months ago (Oct. 6, 2021, 5:46 p.m.)
Indexed	4 weeks, 1 day ago (July 26, 2025, 5:03 a.m.)
Issued	19 years, 2 months ago (June 1, 2006)
Published	19 years, 2 months ago (June 1, 2006)
Published Print	19 years, 2 months ago (June 1, 2006)

Funders 0

None

BibTeX

@article{Mitra_2006, title={RIBOSOME DYNAMICS: Insights from Atomic Structure Modeling into Cryo-Electron Microscopy Maps}, volume={35}, ISSN={1545-4266}, url={http://dx.doi.org/10.1146/annurev.biophys.35.040405.101950}, DOI={10.1146/annurev.biophys.35.040405.101950}, number={1}, journal={Annual Review of Biophysics and Biomolecular Structure}, publisher={Annual Reviews}, author={Mitra, Kakoli and Frank, Joachim}, year={2006}, month=jun, pages={299–317} }

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