DOI: 10.1146/annurev.bioeng.3.1.335. Soft Lithography in Biology and Biochemistry

Soft Lithography in Biology and Biochemistry

10.1146/annurev.bioeng.3.1.335

Crossref journal-article

Annual Reviews

Annual Review of Biomedical Engineering (22)

Abstract

▪ Abstract Soft lithography, a set of techniques for microfabrication, is based on printing and molding using elastomeric stamps with the patterns of interest in bas-relief. As a technique for fabricating microstructures for biological applications, soft lithography overcomes many of the shortcomings of photolithography. In particular, soft lithography offers the ability to control the molecular structure of surfaces and to pattern the complex molecules relevant to biology, to fabricate channel structures appropriate for microfluidics, and to pattern and manipulate cells. For the relatively large feature sizes used in biology (≥50 μm), production of prototype patterns and structures is convenient, inexpensive, and rapid. Self-assembled monolayers of alkanethiolates on gold are particularly easy to pattern by soft lithography, and they provide exquisite control over surface biochemistry.

Bibliography

Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., & Ingber, D. E. (2001). Soft Lithography in Biology and Biochemistry. Annual Review of Biomedical Engineering, 3(1), 335â373.

Authors 5

George M. Whitesides (first)
Emanuele Ostuni (additional)
Shuichi Takayama (additional)
Xingyu Jiang (additional)
Donald E. Ingber (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 7:42 a.m.)
Deposited	3 years, 10 months ago (Oct. 6, 2021, 2:56 p.m.)
Indexed	6 days, 3 hours ago (Aug. 23, 2025, 12:59 a.m.)
Issued	24 years ago (Aug. 1, 2001)
Published	24 years ago (Aug. 1, 2001)
Published Print	24 years ago (Aug. 1, 2001)

Funders 0

None

BibTeX

@article{Whitesides_2001, title={Soft Lithography in Biology and Biochemistry}, volume={3}, ISSN={1545-4274}, url={http://dx.doi.org/10.1146/annurev.bioeng.3.1.335}, DOI={10.1146/annurev.bioeng.3.1.335}, number={1}, journal={Annual Review of Biomedical Engineering}, publisher={Annual Reviews}, author={Whitesides, George M. and Ostuni, Emanuele and Takayama, Shuichi and Jiang, Xingyu and Ingber, Donald E.}, year={2001}, month=aug, pages={335–373} }

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