DOI: 10.1146/annurev.biochem.77.062005.101135. How Does Synaptotagmin Trigger Neurotransmitter Release?

How Does Synaptotagmin Trigger Neurotransmitter Release?
10.1146/annurev.biochem.77.062005.101135
Crossref journal-article
Annual Reviews
Annual Review of Biochemistry (22)
Abstract
Neurotransmitter release at synapses involves a highly specialized form of membrane fusion that is triggered by Ca2+ions and is optimized for speed. These observations were established decades ago, but only recently have the molecular mechanisms that underlie this process begun to come into view. Here, we summarize findings obtained from genetically modified neurons and neuroendocrine cells, as well as from reconstituted systems, which are beginning to reveal the molecular mechanism by which Ca2+—acting on the synaptic vesicle (SV) protein synaptotagmin I (syt)—triggers rapid exocytosis. This work sheds light not only on presynaptic aspects of synaptic transmission, but also on the fundamental problem of membrane fusion, which has remained a puzzle that has yet to be solved in any biological system.
Bibliography
Chapman, E. R. (2008). How Does Synaptotagmin Trigger Neurotransmitter Release? Annual Review of Biochemistry, 77(1), 615â641.
Authors 1
Edwin R. Chapman (first)
References 208 Referenced 461
Dates
Type	When
Created	17 years, 6 months ago (Feb. 14, 2008, 12:45 p.m.)
Deposited	7 months, 1 week ago (Jan. 28, 2025, 10:52 a.m.)
Indexed	12 hours, 19 minutes ago (Sept. 4, 2025, 9:55 a.m.)
Issued	17 years, 3 months ago (June 1, 2008)
Published	17 years, 3 months ago (June 1, 2008)
Published Print	17 years, 3 months ago (June 1, 2008)
Funders 0
None
BibTeX
@article{Chapman_2008, title={How Does Synaptotagmin Trigger Neurotransmitter Release?}, volume={77}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.77.062005.101135}, DOI={10.1146/annurev.biochem.77.062005.101135}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Chapman, Edwin R.}, year={2008}, month=jun, pages={615–641} }
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  "abstract": "<jats:p>Neurotransmitter release at synapses involves a highly specialized form of membrane fusion that is triggered by Ca<jats:sup>2+</jats:sup>ions and is optimized for speed. These observations were established decades ago, but only recently have the molecular mechanisms that underlie this process begun to come into view. Here, we summarize findings obtained from genetically modified neurons and neuroendocrine cells, as well as from reconstituted systems, which are beginning to reveal the molecular mechanism by which Ca<jats:sup>2+</jats:sup>\u2014acting on the synaptic vesicle (SV) protein synaptotagmin I (syt)\u2014triggers rapid exocytosis. This work sheds light not only on presynaptic aspects of synaptic transmission, but also on the fundamental problem of membrane fusion, which has remained a puzzle that has yet to be solved in any biological system.</jats:p>",
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