DOI: 10.1146/annurev.biochem.75.103004.142422. Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression

Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression

10.1146/annurev.biochem.75.103004.142422

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

It is more evident now than ever that nucleosomes can transmit epigenetic information from one cell generation to the next. It has been demonstrated during the past decade that the posttranslational modifications of histone proteins within the chromosome impact chromatin structure, gene transcription, and epigenetic information. Multiple modifications decorate each histone tail within the nucleosome, including some amino acids that can be modified in several different ways. Covalent modifications of histone tails known thus far include acetylation, phosphorylation, sumoylation, ubiquitination, and methylation. A large body of experimental evidence compiled during the past several years has demonstrated the impact of histone acetylation on transcriptional control. Although histone modification by methylation and ubiquitination was discovered long ago, it was only recently that functional roles for these modifications in transcriptional regulation began to surface. Highlighted in this review are the recent biochemical, molecular, cellular, and physiological functions of histone methylation and ubiquitination involved in the regulation of gene expression as determined by a combination of enzymological, structural, and genetic methodologies.

Bibliography

Shilatifard, A. (2006). Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression. Annual Review of Biochemistry, 75(1), 243â269.

Authors 1

Ali Shilatifard (first)

References 145 Referenced 901

Dates

Type	When
Created	19 years, 6 months ago (Feb. 22, 2006, 1:32 p.m.)
Deposited	2 years, 3 months ago (May 6, 2023, 11:31 a.m.)
Indexed	1 day ago (Aug. 23, 2025, 1:02 a.m.)
Issued	19 years, 2 months ago (June 1, 2006)
Published	19 years, 2 months ago (June 1, 2006)
Published Print	19 years, 2 months ago (June 1, 2006)

Funders 0

None

BibTeX

@article{Shilatifard_2006, title={Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression}, volume={75}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.75.103004.142422}, DOI={10.1146/annurev.biochem.75.103004.142422}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Shilatifard, Ali}, year={2006}, month=jun, pages={243–269} }

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