Energy Transduction: Proton Transfer Through the Respiratory Complexes
10.1146/annurev.biochem.75.062003.101730
Crossref journal-article
Annual Reviews
Annual Review of Biochemistry (22)
Abstract

A series of metalloprotein complexes embedded in a mitochondrial or bacterial membrane utilize electron transfer reactions to pump protons across the membrane and create an electrochemical potential (ΔμH+). Current understanding of the principles of electron-driven proton transfer is discussed, mainly with respect to the wealth of knowledge available from studies of cytochrome c oxidase. Structural, experimental, and theoretical evidence supports the model of long-distance proton transfer via hydrogen-bonded water chains in proteins as well as the basic concept that proton uptake and release in a redox-driven pump are driven by charge changes at the membrane-embedded centers. Key elements in the pumping mechanism may include bound water, carboxylates, and the heme propionates, arginines, and associated water above the hemes. There is evidence for an important role of subunit III and proton backflow, but the number and nature of gating mechanisms remain elusive, as does the mechanism of physiological control of efficiency.

Bibliography

Hosler, J. P., Ferguson-Miller, S., & Mills, D. A. (2006). Energy Transduction: Proton Transfer Through the Respiratory Complexes. Annual Review of Biochemistry, 75(1), 165–187.

Authors 3
  1. Jonathan P. Hosler (first)
  2. Shelagh Ferguson-Miller (additional)
  3. Denise A. Mills (additional)
References 145 Referenced 258
  1. 10.1074/jbc.M111860200
  2. 10.1016/S0005-2728(03)00027-6
  3. 10.1042/bss0710203
  4. 10.1146/annurev.physiol.66.032102.150049
  5. 10.1016/S0014-5793(03)00391-0
  6. 10.1016/j.bbabio.2003.10.018
  7. 10.1007/BF01870590
  8. 10.1103/PhysRevLett.90.105902
  9. 10.1016/S0006-3495(03)74526-3
  10. 10.1016/S0022-2836(03)00576-X
  11. 10.1006/jmbi.1999.3027
  12. 10.1002/(SICI)1097-0134(199604)24:4<433::AID-PROT3>3.0.CO;2-F
  13. 10.1073/pnas.2635097100
  14. 10.1038/376660a0
  15. 10.1073/pnas.94.20.10547
  16. 10.1016/S0022-2836(02)00619-8
  17. Qin L. 2005. PhD thesis.X-ray crystallographic studies of cytochromecoxidase fromRhodobacter sphaeroides. Mich. State Univ., East Lansing. 205pp.
  18. 10.1126/science.7652553
  19. 10.1021/cr950051s
  20. 10.1007/BF00762854
  21. 10.1073/pnas.92.5.1604
  22. 10.1126/science.280.5370.1712
  23. 10.1016/j.bbabio.2004.03.006
  24. 10.1021/jp0462456
  25. Sharpe MA, Qin L, Ferguson-Miller S. 2005. InBiophysical and Structural Aspects of Bioenergetics, ed.M Wikstrom, pp.26–54. Cambridge: R. Soc. Chem.
  26. 10.1016/S0005-2728(03)00041-0
  27. 10.1016/S0005-2728(00)00194-8
  28. 10.1021/bi981859k
  29. 10.1021/bi0012641
  30. 10.1016/j.febslet.2004.04.027
  31. 10.1016/j.bbabio.2004.10.004
  32. 10.1073/pnas.081088398
  33. 10.1071/PP9950479
  34. 10.1016/0005-2728(96)00055-2
  35. 10.1021/bi035863u
  36. 10.1021/bi048435c
  37. 10.1016/0014-5793(78)80327-5
  38. 10.1021/bi971876u
  39. 10.1016/S0005-2728(00)00191-2
  40. 10.1073/pnas.080079097
  41. 10.1016/0014-5793(96)00874-5
  42. 10.1021/bi026582+
  43. 10.1042/bj0860541
  44. 10.1021/bi00216a019
  45. 10.1021/bi9629079
  46. 10.1016/0014-5793(90)80062-N
  47. 10.1038/nature03921
  48. 10.1073/pnas.0401521101
  49. 10.1038/22813
  50. 10.1016/S0005-2728(02)00267-0
  51. 10.1038/416099a
  52. 10.1073/pnas.0306036101
  53. 10.1073/pnas.94.17.9085
  54. 10.1074/jbc.M407549200
  55. 10.1021/bi00023a004
  56. 10.1021/bi0101188
  57. 10.1073/pnas.2633243100
  58. 10.1016/j.bbabio.2003.11.008
  59. 10.1016/S0005-2728(98)00077-2
  60. 10.1073/pnas.0408117102
  61. 10.1021/jp0464371
  62. 10.1021/bi9731697
  63. 10.1021/bi034522d
  64. 10.1073/pnas.1530408100
  65. 10.1038/266271a0
  66. 10.1146/annurev.bi.50.070181.003203
  67. 10.1016/0304-4173(85)90002-3
  68. 10.1016/j.febslet.2004.04.016
  69. 10.1021/bi00279a002
  70. 10.1016/0304-4173(87)90002-4
  71. 10.1021/bi00453a001
  72. 10.1016/0014-5793(89)80616-7
  73. 10.1126/science.7652554
  74. 10.1021/bi00022a023
  75. {'key': 'B75', 'first-page': '188', 'volume': '1101', 'author': 'Mitchell R', 'year': '1992', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Mitchell R (1992)
  76. 10.1016/0301-4622(94)00156-E
  77. 10.1021/bi00162a026
  78. 10.1038/338776a0
  79. 10.1038/356301a0
  80. 10.1016/j.bbabio.2003.07.013
  81. 10.1016/0005-2728(94)90093-0
  82. 10.1023/A:1020524014920
  83. 10.1016/S0005-2728(03)00079-3
  84. 10.1016/j.tibs.2004.05.008
  85. 10.1002/(SICI)1097-0134(199801)30:1<100::AID-PROT9>3.0.CO;2-S
  86. 10.1021/bi0502902
  87. 10.1016/S0005-2728(00)00195-X
  88. 10.1073/pnas.88.6.2388
  89. 10.1073/pnas.0500421102
  90. 10.1016/j.bbabio.2003.06.009
  91. 10.1021/bi9914107
  92. 10.1021/bi0341298
  93. 10.1073/pnas.95.15.8590
  94. 10.1021/bi010453w
  95. 10.1016/0005-2728(90)90073-D
  96. 10.1021/bi002574m
  97. 10.1021/bi026524o
  98. 10.1016/S0006-3495(02)75626-9
  99. 10.1021/bi0341307
  100. 10.1016/S0014-5793(03)00392-2
  101. 10.1016/0003-9861(90)90137-N
  102. 10.1002/j.1460-2075.1991.tb07731.x
  103. 10.1021/bi0475774
  104. 10.1085/jgp.114.6.819
  105. 10.1152/physrev.00028.2002
  106. 10.1074/jbc.270.42.25001
  107. 10.1073/pnas.97.4.1542
  108. 10.1016/S0005-2728(00)00182-1
  109. 10.1016/S0005-2728(02)00268-2
  110. 10.1021/bi010280a
  111. 10.1073/pnas.96.11.6183
  112. 10.1016/S0005-2728(98)00040-1
  113. 10.1007/978-1-4615-4843-0_7
  114. 10.1042/bj2100199
  115. 10.1021/bi992235x
  116. 10.1073/pnas.2432106100
  117. 10.1021/bi9606511
  118. 10.1111/j.1742-4658.2004.04480.x
  119. 10.1021/bi050283d
  120. 10.1016/S0006-3495(04)74254-X
  121. 10.1016/S0005-2728(03)00002-1
  122. 10.1016/j.febslet.2005.02.051
  123. 10.1021/bi971813b
  124. 10.1021/bi00068a006
  125. 10.1016/S0006-3495(98)73996-7
  126. 10.1016/S0014-5793(03)00393-4
  127. 10.1007/s00775-003-0509-9
  128. 10.1016/j.pep.2004.11.014
  129. 10.1016/S0006-3495(98)73996-7
  130. 10.1021/bi0502745
  131. 10.1021/bi991504g
  132. 10.1016/S0005-2728(98)00070-X
  133. 10.1016/S0014-5793(03)00387-9
  134. 10.1126/science.277.5322.60
  135. 10.1126/science.281.5373.64
  136. 10.1073/pnas.052704699
  137. 10.1146/annurev.physiol.66.032102.150251
  138. {'key': 'B138', 'first-page': '162', 'volume': '1101', 'author': 'Crofts AR', 'year': '1992', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta by Crofts AR (1992)
  139. 10.1016/S0005-2728(02)00273-6
  140. 10.1016/j.tibs.2005.02.001
  141. 10.1074/jbc.273.34.21603
  142. 10.1016/S0968-0004(01)01897-7
  143. 10.1021/bi990962m
  144. 10.1016/S0969-2126(00)00152-0
  145. 10.1074/jbc.M308247200
Dates
Type When
Created 19 years, 6 months ago (Feb. 16, 2006, 4:30 p.m.)
Deposited 3 years, 10 months ago (Oct. 5, 2021, 6:17 a.m.)
Indexed 1 month, 1 week ago (July 20, 2025, 6:48 p.m.)
Issued 19 years, 3 months ago (June 1, 2006)
Published 19 years, 3 months ago (June 1, 2006)
Published Print 19 years, 3 months ago (June 1, 2006)
Funders 0

None

@article{Hosler_2006, title={Energy Transduction: Proton Transfer Through the Respiratory Complexes}, volume={75}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.75.062003.101730}, DOI={10.1146/annurev.biochem.75.062003.101730}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Hosler, Jonathan P. and Ferguson-Miller, Shelagh and Mills, Denise A.}, year={2006}, month=jun, pages={165–187} }