DOI: 10.1146/annurev.biochem.73.011303.073651. The Sir2 Family of Protein Deacetylases

10.1146/annurev.biochem.73.011303.073651

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

▪ Abstract The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD+-dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In this review, we discuss the role of NAD+, the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 chemical inhibitors and activators that were recently identified. We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging.

Bibliography

Blander, G., & Guarente, L. (2004). The Sir2 Family of Protein Deacetylases. Annual Review of Biochemistry, 73(1), 417â435.

Authors 2

Gil Blander (first)
Leonard Guarente (additional)

References 90 Referenced 1,234

Dates

Type	When
Created	21 years, 2 months ago (June 9, 2004, 5:46 p.m.)
Deposited	2 years, 3 months ago (April 28, 2023, 4:45 p.m.)
Indexed	44 minutes ago (Aug. 27, 2025, 3:52 a.m.)
Issued	21 years, 2 months ago (June 1, 2004)
Published	21 years, 2 months ago (June 1, 2004)
Published Print	21 years, 2 months ago (June 1, 2004)

Funders 0

None

BibTeX

@article{Blander_2004, title={The Sir2 Family of Protein Deacetylases}, volume={73}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.73.011303.073651}, DOI={10.1146/annurev.biochem.73.011303.073651}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Blander, Gil and Guarente, Leonard}, year={2004}, month=jun, pages={417–435} }

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  "abstract": "<jats:p>\u25aa Abstract\u2002 The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging from archaea to humans. Interestingly, Sir2 is active as an NAD<jats:sup>+</jats:sup>-dependent deacetylase, which is broadly conserved from bacteria to higher eukaryotes. In this review, we discuss the role of NAD<jats:sup>+</jats:sup>, the unusual products of the deacetylation reaction, the Sir2 structure, and the Sir2 chemical inhibitors and activators that were recently identified. We summarize the current knowledge of the Sir2 homologs from different organisms, and finally we discuss the role of Sir2 in caloric restriction and aging.</jats:p>",
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