DOI: 10.1146/annurev.biochem.72.121801.161520. The RNA Polymerase II Core Promoter

10.1146/annurev.biochem.72.121801.161520

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation. Specific DNA elements within the core promoter bind the factors that nucleate the assembly of a functional preinitiation complex and integrate stimulatory and repressive signals from factors bound at distal sites. Although core promoter structure was originally thought to be invariant, a remarkable degree of diversity has become apparent. This article reviews the structural and functional diversity of the RNA polymerase II core promoter.

Bibliography

Smale, S. T., & Kadonaga, J. T. (2003). The RNA Polymerase II Core Promoter. Annual Review of Biochemistry, 72(1), 449â479.

Authors 2

Stephen T. Smale (first)
James T. Kadonaga (additional)

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Dates

Type	When
Created	22 years, 4 months ago (March 24, 2003, 8:44 p.m.)
Deposited	3 years, 10 months ago (Oct. 5, 2021, 5:53 a.m.)
Indexed	4 days ago (Aug. 19, 2025, 6:31 a.m.)
Issued	22 years, 2 months ago (June 1, 2003)
Published	22 years, 2 months ago (June 1, 2003)
Published Print	22 years, 2 months ago (June 1, 2003)

Funders 0

None

BibTeX

@article{Smale_2003, title={The RNA Polymerase II Core Promoter}, volume={72}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.72.121801.161520}, DOI={10.1146/annurev.biochem.72.121801.161520}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Smale, Stephen T. and Kadonaga, James T.}, year={2003}, month=jun, pages={449–479} }

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  "abstract": "<jats:p> \u25aa Abstract\u2002 The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend \u223c35 bp upstream and/or downstream of this site, plays a central role in regulating initiation. Specific DNA elements within the core promoter bind the factors that nucleate the assembly of a functional preinitiation complex and integrate stimulatory and repressive signals from factors bound at distal sites. Although core promoter structure was originally thought to be invariant, a remarkable degree of diversity has become apparent. This article reviews the structural and functional diversity of the RNA polymerase II core promoter. </jats:p>",
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