eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
10.1146/annurev.biochem.68.1.913
Crossref journal-article
Annual Reviews
Annual Review of Biochemistry (22)
Abstract

▪ Abstract  Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under most circumstances and a primary target for translational control. Functions of the constituent proteins of eIF4F include recognition of the mRNA 5′ cap structure (eIF4E), delivery of an RNA helicase to the 5′ region (eIF4A), bridging of the mRNA and the ribosome (eIF4G), and circularization of the mRNA via interaction with poly(A)-binding protein (eIF4G). eIF4 activity is regulated by transcription, phosphorylation, inhibitory proteins, and proteolytic cleavage. Extracellular stimuli evoke changes in phosphorylation that influence eIF4F activity, especially through the phosphoinositide 3-kinase (PI3K) and Ras signaling pathways. Viral infection and cellular stresses also affect eIF4F function. The recent determination of the structure of eIF4E at atomic resolution has provided insight about how translation is initiated and regulated. Evidence suggests that eIF4F is also implicated in malignancy and apoptosis.

Bibliography

Gingras, A.-C., Raught, B., & Sonenberg, N. (1999). eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation. Annual Review of Biochemistry, 68(1), 913–963.

Authors 3
  1. Anne-Claude Gingras (first)
  2. Brian Raught (additional)
  3. Nahum Sonenberg (additional)
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Dates
Type When
Created 23 years ago (July 27, 2002, 7:42 a.m.)
Deposited 2 years, 4 months ago (April 23, 2023, 2:51 p.m.)
Indexed 5 days, 1 hour ago (Aug. 19, 2025, 6:08 a.m.)
Issued 26 years, 2 months ago (June 1, 1999)
Published 26 years, 2 months ago (June 1, 1999)
Published Print 26 years, 2 months ago (June 1, 1999)
Funders 0

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@article{Gingras_1999, title={eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation}, volume={68}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.68.1.913}, DOI={10.1146/annurev.biochem.68.1.913}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Gingras, Anne-Claude and Raught, Brian and Sonenberg, Nahum}, year={1999}, month=jun, pages={913–963} }