DOI: 10.1146/annurev.biochem.67.1.721. THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

10.1146/annurev.biochem.67.1.721

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly coordinated process that ensures accurate and efficient genome duplication. Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. At least two different DNA polymerases, a single-stranded DNA-binding protein, a clamp-loading complex, and a polymerase clamp combine to replicate DNA. Okazaki fragment synthesis involves a DNA polymerase-switching mechanism, and maturation occurs by the recruitment of specific nucleases, a helicase, and a ligase. The process of DNA replication is also coupled to cell-cycle progression and to DNA repair to maintain genome integrity.

Bibliography

Waga, S., & Stillman, B. (1998). THE DNA REPLICATION FORK IN EUKARYOTIC CELLS. Annual Review of Biochemistry, 67(1), 721â751.

Authors 2

Shou Waga (first)
Bruce Stillman (additional)

References 315 Referenced 652

10.1101/gad.10.22.2819
10.1126/science.274.5293.1659
10.1073/pnas.81.22.6973
10.1128/MCB.5.6.1238
10.1128/MCB.5.8.2051
10.1073/pnas.82.17.5710
10.1146/annurev.bi.58.070189.003323
10.1146/annurev.cb.05.110189.001213
10.1016/S0079-6603(08)60877-6
10.1074/jbc.272.8.4647
10.1146/annurev.bi.61.070192.001343
Nash R, Lindahl T. 1996. See Ref.314, pp. 575–86
Andersen AH, Bendixen C, Westergaard O. 1996. See Ref.314, pp. 587–617
Wang TS-F. 1996. See Ref.314, pp. 461–93 (10.1136/bmj.314.7079.461j)
10.1128/jvi.62.8.2867-2873.1988 / J. Virol. by Nethanel T (1988)
10.1073/pnas.87.24.9712
10.1128/jvi.64.12.5912-5918.1990 / J. Virol. by Nethanel T (1990)
10.1128/MCB.11.5.2350
10.1073/pnas.89.3.952
Salas M, Miller JT, Leis J, DePamphilis ML. 1996. See Ref.314, pp. 131–76
10.1016/0092-8674(88)90493-X
10.1073/pnas.86.19.7361
10.1073/pnas.86.24.9742
10.1038/346534a0
10.1016/S0021-9258(18)52386-3 / J. Biol. Chem. by Tsurimoto T (1991)
10.1038/369207a0
10.1016/S0021-9258(18)82086-5 / J. Biol. Chem. by Murakami Y (1993)
10.1146/annurev.bi.60.070191.002501
10.1111/j.1432-1033.1994.tb18925.x
10.1128/MCB.15.3.1716
10.1093/genetics/133.2.183 / Genetics by Longhese MP (1993)
10.1074/jbc.270.8.3905
10.1128/MCB.16.7.3235
10.1016/S0021-9258(18)54081-3 / J. Biol. Chem. by Santocanale C (1993)
10.1016/S0021-9258(18)47084-6 / J. Biol. Chem. by Bakkenist CJ (1994)
10.1002/j.1460-2075.1993.tb06144.x
10.1128/MCB.14.2.923
10.1016/S0021-9258(20)89534-9 / J. Biol. Chem. by Nasheuer H-P (1991)
10.1128/MCB.15.2.883
10.1074/jbc.271.15.8661
10.1038/sj.onc.1200975
Hübscher U, Maga G, Podust VN. 1996. See Ref.314, pp. 525–43
10.1146/annurev.biochem.66.1.61
10.1073/pnas.84.7.1834
10.1002/j.1460-2075.1988.tb02933.x
10.1073/pnas.85.8.2523
10.1146/annurev.bi.65.070196.000355
10.1002/j.1460-2075.1986.tb04447.x
10.1073/pnas.84.1.16
10.1126/science.2823389
10.1073/pnas.84.11.3643
10.1038/342092a0
10.1073/pnas.86.24.9757
10.1002/j.1460-2075.1989.tb08567.x
10.1016/S0021-9258(18)99069-1 / J. Biol. Chem. by Erdile LF (1991)
10.1016/S0021-9258(18)52385-1 / J. Biol. Chem. by Tsurimoto T (1991)
10.1021/bi970473r
10.1128/MCB.14.12.7884
10.1002/j.1460-2075.1992.tb05110.x
10.1016/S0021-9258(18)53706-6 / J. Biol. Chem. by Melendy T (1993)
10.1074/jbc.271.34.20868
10.1016/S0021-9258(19)78100-9 / J. Biol. Chem. by Henricksen LA (1994)
10.1074/jbc.271.45.28243
10.1073/pnas.91.2.579
10.1074/jbc.270.9.4534
10.1074/jbc.271.25.15124
10.1074/jbc.271.29.17190
10.1101/gad.10.17.2222
10.1038/385176a0
10.1128/MCB.14.6.3993
10.1021/bi00251a031
10.1042/bj3240957
10.1101/gad.4.6.968
10.1128/MCB.13.12.7222
10.1002/j.1460-2075.1994.tb06487.x
10.1002/j.1460-2075.1992.tb05278.x
10.1002/j.1460-2075.1992.tb05277.x
10.1073/pnas.91.26.12520
10.1073/pnas.91.18.8343
10.1128/MCB.15.10.5700
10.1073/pnas.93.24.13825
10.1074/jbc.271.37.22847
10.1074/jbc.272.19.12634
10.1074/jbc.272.38.23896
10.1073/pnas.93.26.15075
10.1016/0167-8140(96)01712-4
10.1073/pnas.94.14.7186
10.1016/S0021-9258(19)51069-9 / J. Biol. Chem. by Henricksen LA (1994)
10.1073/pnas.92.10.4636
10.1093/nar/24.15.3107
{'key': 'b91', 'first-page': '3386', 'volume': '57', 'author': 'Morgan SE', 'year': '1997', 'journal-title': 'Cancer Res.'} / Cancer Res. by Morgan SE (1997)
10.1083/jcb.119.1.1
10.1126/science.7569932
10.1016/S0092-8674(00)81322-7
Stillman B. 1996. See Ref.314, pp. 435–60 (10.7209/tanso.1996.314)
10.1073/pnas.89.12.5211
10.1073/pnas.89.7.2516
10.1073/pnas.90.23.11014
10.1073/pnas.90.24.11543
10.1128/MCB.14.1.255
10.1073/pnas.91.3.868
10.1016/S0021-9258(17)31884-7 / J. Biol. Chem. by Li XY (1994)
10.1093/nar/22.9.1527
10.1128/MCB.15.9.4661
10.1096/fasebj.11.1.9034168
10.1093/nar/21.1.1
10.1128/MCB.9.2.609
10.1073/pnas.87.3.1023
10.1016/S0021-9258(18)52476-5 / J. Biol. Chem. by Lee S-H (1991)
10.1016/S0021-9258(18)54624-X / J. Biol. Chem. by Yoder BL (1991)
10.1128/MCB.12.1.155
10.1093/nar/20.16.4159
10.1016/S0021-9258(18)54625-1 / J. Biol. Chem. by Burgers PMJ (1991)
10.1073/pnas.93.23.12896
10.1021/bi00027a039
10.1073/pnas.87.15.5672
10.1074/jbc.272.10.6303
10.1074/jbc.273.10.5979
10.1074/jbc.272.2.1256
10.1002/j.1460-2075.1996.tb00815.x
10.1074/jbc.272.3.1769
10.1074/jbc.272.15.10058
10.1093/emboj/16.21.6346
10.1006/bbrc.1997.6456
10.1074/jbc.272.15.10065
10.1073/pnas.93.13.6521
10.1074/jbc.272.30.18974
10.1128/MCB.14.7.4390
10.1128/MCB.17.10.5905
10.1016/S0092-8674(00)80417-1
10.1002/bies.950191106
10.1038/sj.onc.1200886
10.1016/0092-8674(92)90445-I
10.1016/0092-8674(94)90014-0
10.1146/annurev.bi.64.070195.001131
10.1002/j.1460-2075.1994.tb06867.x
10.1016/S0021-9258(19)51070-5 / J. Biol. Chem. by Hacker KJ (1994)
10.1016/S0021-9258(19)51071-7 / J. Biol. Chem. by Hacker KJ (1994)
10.1016/S0092-8674(94)90662-9
10.1016/S0021-9258(18)67240-0 / J. Biol. Chem. by Tan CK (1986)
10.1038/326515a0
10.1038/326471a0
10.1038/326517a0
10.1073/pnas.85.20.7506
10.1016/S0021-9258(19)39704-2 / J. Biol. Chem. by Hamatake RK (1990)
10.1016/S0021-9258(18)54626-3 / J. Biol. Chem. by Lee S-H (1991)
10.1074/jbc.270.14.7799
10.1128/MCB.15.8.4420
10.1074/jbc.270.38.22527
10.1074/jbc.271.27.15971
10.1128/MCB.17.11.6367
10.1074/jbc.270.38.22109
10.1073/pnas.93.21.11597
10.1073/pnas.94.24.12863
10.1073/pnas.91.18.8655
10.1038/369574a0
10.1126/science.7973727
{'key': 'b158', 'first-page': '2427', 'volume': '10', 'author': 'Hall PA', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene by Hall PA (1995)
10.1074/jbc.272.39.24522
10.1126/science.277.5334.1996
10.1016/S0092-8674(00)81323-9
10.1016/0092-8674(92)90518-H
10.1016/S0021-9258(19)78087-9 / J. Biol. Chem. by Matsuoka S (1994)
10.1016/S0092-8674(00)81347-1
10.1006/excr.1996.0220
10.1083/jcb.105.4.1549
10.1242/jcs.103.1.97 / J. Cell Sci. by Humbert C (1992)
10.1016/S0960-9822(02)00452-9
10.1016/0014-5793(86)81127-9
10.1083/jcb.107.5.1623
10.1016/0014-4827(92)90308-U
10.1101/gad.8.14.1627
10.1007/BF00292709
10.1002/j.1460-2075.1996.tb00839.x
10.1073/pnas.94.21.11244
10.1002/j.1460-2075.1989.tb03580.x
10.1016/0022-2836(91)90207-M
10.1021/bi00115a002
10.1093/nar/20.4.735
10.1016/0378-1119(93)90093-I
10.1091/mbc.4.2.145
10.1093/nar/23.17.3493
10.1006/geno.1995.1229
10.1093/nar/25.6.1094
10.1016/S0021-9258(20)80599-7 / J. Biol. Chem. by Brown WC (1993)
10.1074/jbc.270.14.7988
10.1016/S0021-9258(17)46237-5 / J. Biol. Chem. by Goulian M (1990)
10.1073/pnas.90.19.9105
10.1016/S0021-9258(18)52384-X / J. Biol. Chem. by Melendy T (1991)
10.1073/pnas.87.22.8692
10.1016/S0021-9258(18)42517-3 / J. Biol. Chem. by Eki T (1992)
10.1016/S0021-9258(17)34146-7 / J. Biol. Chem. by Waga S (1994)
10.1021/bi952455k
10.1021/bi9530649
10.1002/j.1460-2075.1996.tb00583.x
10.1016/0092-8674(90)90391-Q
10.1002/j.1460-2075.1992.tb05106.x
10.1128/MCB.13.1.496
10.1093/nar/21.4.841
10.1073/pnas.91.21.9803
10.1002/bies.950190309
10.1101/gad.8.11.1344
10.1128/MCB.14.7.4878
10.1002/j.1460-2075.1994.tb06373.x
10.1016/S0021-9258(19)77695-9 / J. Biol. Chem. by Ishimi Y (1988)
10.1016/S0021-9258(17)44775-2 / J. Biol. Chem. by Goulian M (1990)
10.1016/S0021-9258(19)61935-6 / J. Biol. Chem. by Robins P (1994)
10.1073/pnas.89.20.9377
10.1016/S0021-9258(19)81589-2 / J. Biol. Chem. by Kenny MK (1988)
10.1128/jb.177.2.364-371.1995
10.1074/jbc.270.9.4193
10.1016/S0021-9258(18)82447-4 / J. Biol. Chem. by Turchi JJ (1993)
10.1016/S0021-9258(17)42241-1 / J. Biol. Chem. by Murante RS (1994)
10.1021/bi9603074
10.1074/jbc.271.42.25888
10.1074/jbc.270.51.30377
10.1021/bi962890u
10.1126/science.7618086
10.1016/S0092-8674(00)81846-2
10.1038/ng0697-116
10.1016/S0092-8674(00)81832-2
10.1016/S0021-9258(18)50326-4 / J. Biol. Chem. by Cathala G (1979)
10.1016/S0021-9258(19)70581-X / J. Biol. Chem. by Büsen W (1980)
10.1016/S0021-9258(17)38638-6 / J. Biol. Chem. by DiFrancesco RA (1985)
10.1111/j.1432-1033.1989.tb15158.x
10.1016/S0021-9258(18)38142-0 / J. Biol. Chem. by Eder PS (1991)
10.1016/S0021-9258(18)47334-6 / J. Biol. Chem. by Huang L (1994)
10.1074/jbc.272.36.22591
Borowiec JA. 1996. See Ref.314, pp. 545–74
10.1128/jvi.66.2.804-815.1992 / J. Virol. by Wessel R (1992)
10.1073/pnas.80.21.6465
10.1073/pnas.92.17.7642
10.1074/jbc.270.45.26766
10.1021/bi00024a016
10.1093/nar/23.11.2014
10.1128/MCB.15.1.165
10.1016/S0968-0004(96)10013-X
10.1002/bies.950180305
10.1093/nar/21.11.2541
10.1046/j.1365-2443.1997.1350333.x
10.1016/S0092-8674(01)80009-X
10.1074/jbc.272.39.24508
10.1002/(SICI)1097-4644(19961201)63:3<259::AID-JCB1>3.0.CO;2-W
10.1128/MCB.17.4.2136
10.1128/MCB.17.7.4178
10.1128/MCB.12.12.5736
10.1128/MCB.12.12.5724
10.1073/pnas.89.4.1276
10.1093/genetics/124.1.81 / Genetics by Prendergast JA (1990)
10.1128/MCB.11.11.5710
10.1128/MCB.11.11.5718
10.1128/MCB.15.8.4291
10.1146/annurev.bi.61.070192.000415
Deleted in proof
10.1016/S0021-9258(18)82087-7 / J. Biol. Chem. by Murakami Y (1993)
10.1128/MCB.6.11.4077
10.1038/329456a0
10.1002/j.1460-2075.1990.tb07533.x
10.1128/MCB.13.2.809
10.1073/pnas.91.18.8700
10.1128/MCB.11.4.2108
10.1128/MCB.14.5.3176
10.1128/MCB.16.1.94
10.1128/MCB.13.5.2882
10.1128/MCB.14.8.5043
10.1128/MCB.15.1.173
10.1016/S0021-9258(19)38289-4 / J. Biol. Chem. by Goulian M (1990)
10.1016/S0021-9258(19)38288-2 / J. Biol. Chem. by Goulian M (1990)
10.1016/0092-8674(93)90650-F
10.1016/0092-8674(93)90649-B
10.1016/S0021-9258(17)34526-X / J. Biol. Chem. by Eliasson R (1978)
10.1093/genetics/142.3.717 / Genetics by Shcherbakova PV (1996)
10.1016/0092-8674(95)90448-4
10.1101/gad.10.20.2632
10.1126/science.274.5293.1664
10.1073/pnas.93.14.7048
10.1073/pnas.92.25.11791
10.1016/0092-8674(93)90428-S
10.1002/j.1460-2075.1994.tb06866.x
10.1101/gad.11.24.3387
10.1128/MCB.17.5.2381
10.1093/emboj/16.3.639
10.1242/jcs.108.9.3109 / J. Cell Sci. by D'Urso G (1995)
10.1007/BF00298962
10.1038/374817a0
10.1128/MCB.17.10.5905
10.1016/0092-8674(95)90481-6
10.1002/j.1460-2075.1992.tb05618.x
10.1101/gad.9.10.1149
10.1126/science.274.5293.1672
10.1101/gad.7.8.1572
10.1016/S0960-9822(00)00196-2
10.1083/jcb.130.4.755
10.1093/nar/20.10.2441
10.1016/0092-8674(92)90416-A
10.1038/371534a0
10.1016/S0960-9822(00)00244-X
10.1038/374386a0
{'key': 'b299', 'first-page': '2281', 'volume': '10', 'author': 'Goubin F', 'year': '1995', 'journal-title': 'Oncogene'} / Oncogene by Goubin F (1995)
10.1038/375159a0
10.1074/jbc.270.29.17060
10.1016/S0960-9822(95)00058-3
{'key': 'b303', 'first-page': '595', 'volume': '12', 'author': 'Chen I-T', 'year': '1996', 'journal-title': 'Oncogene'} / Oncogene by Chen I-T (1996)
10.1128/MCB.16.9.4673
10.1074/jbc.272.4.2373
10.1038/sj.onc.1201072
10.1101/gad.11.16.2090
10.1101/gad.11.16.2101
Greider CW, Collins K, Autexier C. 1996. See Ref.314, pp. 619–38
10.1016/S0092-8674(85)80120-3
10.1128/MCB.16.9.4614
10.1091/mbc.8.11.2145
10.1126/science.274.5285.249
10.1016/S0092-8674(94)90362-X
{'key': 'b315', 'volume-title': 'DNA Replication in Eukaryotic Cells.', 'author': 'De Pamphilis ML', 'year': '1996'} / DNA Replication in Eukaryotic Cells. by De Pamphilis ML (1996)

Dates

Type	When
Created	23 years ago (July 27, 2002, 7:42 a.m.)
Deposited	3 years, 10 months ago (Oct. 5, 2021, 9:44 a.m.)
Indexed	3 weeks, 2 days ago (July 30, 2025, 11:13 a.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Waga_1998, title={THE DNA REPLICATION FORK IN EUKARYOTIC CELLS}, volume={67}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.67.1.721}, DOI={10.1146/annurev.biochem.67.1.721}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Waga, Shou and Stillman, Bruce}, year={1998}, month=jun, pages={721–751} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T15:13:30Z",
    "timestamp": 1753888410506
  },
  "reference-count": 315,
  "publisher": "Annual Reviews",
  "issue": "1",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "abstract": "<jats:p> Replication of the two template strands at eukaryotic cell DNA replication forks is a highly coordinated process that ensures accurate and efficient genome duplication. Biochemical studies, principally of plasmid DNAs containing the Simian Virus 40 origin of DNA replication, and yeast genetic studies have uncovered the fundamental mechanisms of replication fork progression. At least two different DNA polymerases, a single-stranded DNA-binding protein, a clamp-loading complex, and a polymerase clamp combine to replicate DNA. Okazaki fragment synthesis involves a DNA polymerase-switching mechanism, and maturation occurs by the recruitment of specific nucleases, a helicase, and a ligase. The process of DNA replication is also coupled to cell-cycle progression and to DNA repair to maintain genome integrity. </jats:p>",
  "DOI": "10.1146/annurev.biochem.67.1.721",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        7,
        27
      ]
    ],
    "date-time": "2002-07-27T11:42:12Z",
    "timestamp": 1027770132000
  },
  "page": "721-751",
  "source": "Crossref",
  "is-referenced-by-count": 652,
  "title": "THE DNA REPLICATION FORK IN EUKARYOTIC CELLS",
  "prefix": "10.1146",
  "volume": "67",
  "author": [
    {
      "given": "Shou",
      "family": "Waga",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, New York 11724"
        }
      ]
    },
    {
      "given": "Bruce",
      "family": "Stillman",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, New York 11724"
        }
      ]
    }
  ],
  "member": "22",
  "reference": [
    {
      "key": "b1",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.10.22.2819"
    },
    {
      "key": "b2",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.274.5293.1659"
    },
    {
      "key": "b3",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.81.22.6973"
    },
    {
      "key": "b4",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.5.6.1238"
    },
    {
      "key": "b5",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.5.8.2051"
    },
    {
      "key": "b6",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.82.17.5710"
    },
    {
      "key": "b7",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.58.070189.003323"
    },
    {
      "key": "b8",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.cb.05.110189.001213"
    },
    {
      "key": "b9",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0079-6603(08)60877-6"
    },
    {
      "key": "b10",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.8.4647"
    },
    {
      "key": "b11",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.61.070192.001343"
    },
    {
      "key": "b12",
      "unstructured": "Nash R, Lindahl T. 1996. See Ref.314, pp. 575\u201386"
    },
    {
      "key": "b13",
      "unstructured": "Andersen AH, Bendixen C, Westergaard O. 1996. See Ref.314, pp. 587\u2013617"
    },
    {
      "key": "b14",
      "doi-asserted-by": "crossref",
      "unstructured": "Wang TS-F. 1996. See Ref.314, pp. 461\u201393",
      "DOI": "10.1136/bmj.314.7079.461j"
    },
    {
      "key": "b15",
      "doi-asserted-by": "crossref",
      "first-page": "2867",
      "DOI": "10.1128/jvi.62.8.2867-2873.1988",
      "volume": "6",
      "author": "Nethanel T",
      "year": "1988",
      "journal-title": "J. Virol."
    },
    {
      "key": "b16",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.24.9712"
    },
    {
      "key": "b17",
      "doi-asserted-by": "crossref",
      "first-page": "5912",
      "DOI": "10.1128/jvi.64.12.5912-5918.1990",
      "volume": "64",
      "author": "Nethanel T",
      "year": "1990",
      "journal-title": "J. Virol."
    },
    {
      "key": "b18",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.5.2350"
    },
    {
      "key": "b19",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.3.952"
    },
    {
      "key": "b20",
      "unstructured": "Salas M, Miller JT, Leis J, DePamphilis ML. 1996. See Ref.314, pp. 131\u201376"
    },
    {
      "key": "b21",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(88)90493-X"
    },
    {
      "key": "b22",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.19.7361"
    },
    {
      "key": "b23",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.24.9742"
    },
    {
      "key": "b24",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/346534a0"
    },
    {
      "key": "b25",
      "doi-asserted-by": "crossref",
      "first-page": "1961",
      "DOI": "10.1016/S0021-9258(18)52386-3",
      "volume": "266",
      "author": "Tsurimoto T",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b26",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/369207a0"
    },
    {
      "key": "b27",
      "doi-asserted-by": "crossref",
      "first-page": "11008",
      "DOI": "10.1016/S0021-9258(18)82086-5",
      "volume": "268",
      "author": "Murakami Y",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b28",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.60.070191.002501"
    },
    {
      "key": "b29",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1994.tb18925.x"
    },
    {
      "key": "b30",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.3.1716"
    },
    {
      "key": "b31",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1093/genetics/133.2.183",
      "volume": "133",
      "author": "Longhese MP",
      "year": "1993",
      "journal-title": "Genetics"
    },
    {
      "key": "b32",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.8.3905"
    },
    {
      "key": "b33",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.7.3235"
    },
    {
      "key": "b34",
      "doi-asserted-by": "crossref",
      "first-page": "1343",
      "DOI": "10.1016/S0021-9258(18)54081-3",
      "volume": "268",
      "author": "Santocanale C",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b35",
      "doi-asserted-by": "crossref",
      "first-page": "26759",
      "DOI": "10.1016/S0021-9258(18)47084-6",
      "volume": "269",
      "author": "Bakkenist CJ",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b36",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1993.tb06144.x"
    },
    {
      "key": "b37",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.2.923"
    },
    {
      "key": "b38",
      "doi-asserted-by": "crossref",
      "first-page": "7893",
      "DOI": "10.1016/S0021-9258(20)89534-9",
      "volume": "266",
      "author": "Nasheuer H-P",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b39",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.2.883"
    },
    {
      "key": "b40",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.15.8661"
    },
    {
      "key": "b41",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1200975"
    },
    {
      "key": "b42",
      "unstructured": "H\u00fcbscher U, Maga G, Podust VN. 1996. See Ref.314, pp. 525\u201343"
    },
    {
      "key": "b43",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.biochem.66.1.61"
    },
    {
      "key": "b44",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.7.1834"
    },
    {
      "key": "b45",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1988.tb02933.x"
    },
    {
      "key": "b46",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.85.8.2523"
    },
    {
      "key": "b47",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.65.070196.000355"
    },
    {
      "key": "b48",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1986.tb04447.x"
    },
    {
      "key": "b49",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.1.16"
    },
    {
      "key": "b50",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.2823389"
    },
    {
      "key": "b51",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.84.11.3643"
    },
    {
      "key": "b52",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/342092a0"
    },
    {
      "key": "b53",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.86.24.9757"
    },
    {
      "key": "b54",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb08567.x"
    },
    {
      "key": "b55",
      "doi-asserted-by": "crossref",
      "first-page": "12090",
      "DOI": "10.1016/S0021-9258(18)99069-1",
      "volume": "266",
      "author": "Erdile LF",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b56",
      "doi-asserted-by": "crossref",
      "first-page": "1950",
      "DOI": "10.1016/S0021-9258(18)52385-1",
      "volume": "266",
      "author": "Tsurimoto T",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b57",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi970473r"
    },
    {
      "key": "b58",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.12.7884"
    },
    {
      "key": "b59",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05110.x"
    },
    {
      "key": "b60",
      "doi-asserted-by": "crossref",
      "first-page": "3389",
      "DOI": "10.1016/S0021-9258(18)53706-6",
      "volume": "268",
      "author": "Melendy T",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b61",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.34.20868"
    },
    {
      "key": "b62",
      "doi-asserted-by": "crossref",
      "first-page": "11121",
      "DOI": "10.1016/S0021-9258(19)78100-9",
      "volume": "269",
      "author": "Henricksen LA",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b63",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.45.28243"
    },
    {
      "key": "b64",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.2.579"
    },
    {
      "key": "b65",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.9.4534"
    },
    {
      "key": "b66",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.25.15124"
    },
    {
      "key": "b67",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.29.17190"
    },
    {
      "key": "b68",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.10.17.2222"
    },
    {
      "key": "b69",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/385176a0"
    },
    {
      "key": "b70",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.6.3993"
    },
    {
      "key": "b71",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00251a031"
    },
    {
      "key": "b72",
      "doi-asserted-by": "publisher",
      "DOI": "10.1042/bj3240957"
    },
    {
      "key": "b73",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.4.6.968"
    },
    {
      "key": "b74",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.12.7222"
    },
    {
      "key": "b75",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06487.x"
    },
    {
      "key": "b76",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05278.x"
    },
    {
      "key": "b77",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05277.x"
    },
    {
      "key": "b78",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.26.12520"
    },
    {
      "key": "b79",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.18.8343"
    },
    {
      "key": "b80",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.10.5700"
    },
    {
      "key": "b81",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.24.13825"
    },
    {
      "key": "b82",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.37.22847"
    },
    {
      "key": "b83",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.19.12634"
    },
    {
      "key": "b84",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.38.23896"
    },
    {
      "key": "b85",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.26.15075"
    },
    {
      "key": "b86",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0167-8140(96)01712-4"
    },
    {
      "key": "b87",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.14.7186"
    },
    {
      "key": "b88",
      "doi-asserted-by": "crossref",
      "first-page": "24203",
      "DOI": "10.1016/S0021-9258(19)51069-9",
      "volume": "269",
      "author": "Henricksen LA",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b89",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.10.4636"
    },
    {
      "key": "b90",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/24.15.3107"
    },
    {
      "key": "b91",
      "first-page": "3386",
      "volume": "57",
      "author": "Morgan SE",
      "year": "1997",
      "journal-title": "Cancer Res."
    },
    {
      "key": "b92",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.119.1.1"
    },
    {
      "key": "b93",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7569932"
    },
    {
      "key": "b94",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81322-7"
    },
    {
      "key": "b95",
      "doi-asserted-by": "crossref",
      "unstructured": "Stillman B. 1996. See Ref.314, pp. 435\u201360",
      "DOI": "10.7209/tanso.1996.314"
    },
    {
      "key": "b96",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.12.5211"
    },
    {
      "key": "b97",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.7.2516"
    },
    {
      "key": "b98",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.23.11014"
    },
    {
      "key": "b99",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.24.11543"
    },
    {
      "key": "b100",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.1.255"
    },
    {
      "key": "b101",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.3.868"
    },
    {
      "key": "b102",
      "doi-asserted-by": "crossref",
      "first-page": "21880",
      "DOI": "10.1016/S0021-9258(17)31884-7",
      "volume": "269",
      "author": "Li XY",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b103",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/22.9.1527"
    },
    {
      "key": "b104",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.9.4661"
    },
    {
      "key": "b105",
      "doi-asserted-by": "publisher",
      "DOI": "10.1096/fasebj.11.1.9034168"
    },
    {
      "key": "b106",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/21.1.1"
    },
    {
      "key": "b107",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.9.2.609"
    },
    {
      "key": "b108",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.3.1023"
    },
    {
      "key": "b109",
      "doi-asserted-by": "crossref",
      "first-page": "594",
      "DOI": "10.1016/S0021-9258(18)52476-5",
      "volume": "266",
      "author": "Lee S-H",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b110",
      "doi-asserted-by": "crossref",
      "first-page": "22689",
      "DOI": "10.1016/S0021-9258(18)54624-X",
      "volume": "266",
      "author": "Yoder BL",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b111",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.12.1.155"
    },
    {
      "key": "b112",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/20.16.4159"
    },
    {
      "key": "b113",
      "doi-asserted-by": "crossref",
      "first-page": "22698",
      "DOI": "10.1016/S0021-9258(18)54625-1",
      "volume": "266",
      "author": "Burgers PMJ",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b114",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.23.12896"
    },
    {
      "key": "b115",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00027a039"
    },
    {
      "key": "b116",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.15.5672"
    },
    {
      "key": "b117",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.10.6303"
    },
    {
      "key": "b118",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.273.10.5979"
    },
    {
      "key": "b119",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.2.1256"
    },
    {
      "key": "b120",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00815.x"
    },
    {
      "key": "b121",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.3.1769"
    },
    {
      "key": "b122",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.15.10058"
    },
    {
      "key": "b123",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.21.6346"
    },
    {
      "key": "b124",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/bbrc.1997.6456"
    },
    {
      "key": "b125",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.15.10065"
    },
    {
      "key": "b126",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.13.6521"
    },
    {
      "key": "b127",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.30.18974"
    },
    {
      "key": "b128",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.7.4390"
    },
    {
      "key": "b129",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.10.5905"
    },
    {
      "key": "b130",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)80417-1"
    },
    {
      "key": "b131",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bies.950191106"
    },
    {
      "key": "b132",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1200886"
    },
    {
      "key": "b133",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90445-I"
    },
    {
      "key": "b134",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(94)90014-0"
    },
    {
      "key": "b135",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.64.070195.001131"
    },
    {
      "key": "b136",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06867.x"
    },
    {
      "key": "b137",
      "doi-asserted-by": "crossref",
      "first-page": "24209",
      "DOI": "10.1016/S0021-9258(19)51070-5",
      "volume": "269",
      "author": "Hacker KJ",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b138",
      "doi-asserted-by": "crossref",
      "first-page": "24221",
      "DOI": "10.1016/S0021-9258(19)51071-7",
      "volume": "269",
      "author": "Hacker KJ",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b139",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(94)90662-9"
    },
    {
      "key": "b140",
      "doi-asserted-by": "crossref",
      "first-page": "12310",
      "DOI": "10.1016/S0021-9258(18)67240-0",
      "volume": "261",
      "author": "Tan CK",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b141",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326515a0"
    },
    {
      "key": "b142",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326471a0"
    },
    {
      "key": "b143",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/326517a0"
    },
    {
      "key": "b144",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.85.20.7506"
    },
    {
      "key": "b145",
      "doi-asserted-by": "crossref",
      "first-page": "4072",
      "DOI": "10.1016/S0021-9258(19)39704-2",
      "volume": "265",
      "author": "Hamatake RK",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b146",
      "doi-asserted-by": "crossref",
      "first-page": "22707",
      "DOI": "10.1016/S0021-9258(18)54626-3",
      "volume": "266",
      "author": "Lee S-H",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b147",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.14.7799"
    },
    {
      "key": "b148",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.8.4420"
    },
    {
      "key": "b149",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.38.22527"
    },
    {
      "key": "b150",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.27.15971"
    },
    {
      "key": "b151",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.11.6367"
    },
    {
      "key": "b152",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.38.22109"
    },
    {
      "key": "b153",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.21.11597"
    },
    {
      "key": "b154",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.24.12863"
    },
    {
      "key": "b155",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.18.8655"
    },
    {
      "key": "b156",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/369574a0"
    },
    {
      "key": "b157",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7973727"
    },
    {
      "key": "b158",
      "first-page": "2427",
      "volume": "10",
      "author": "Hall PA",
      "year": "1995",
      "journal-title": "Oncogene"
    },
    {
      "key": "b159",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.39.24522"
    },
    {
      "key": "b160",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.277.5334.1996"
    },
    {
      "key": "b161",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81323-9"
    },
    {
      "key": "b162",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90518-H"
    },
    {
      "key": "b163",
      "doi-asserted-by": "crossref",
      "first-page": "11030",
      "DOI": "10.1016/S0021-9258(19)78087-9",
      "volume": "269",
      "author": "Matsuoka S",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b164",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81347-1"
    },
    {
      "key": "b165",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/excr.1996.0220"
    },
    {
      "key": "b166",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.105.4.1549"
    },
    {
      "key": "b167",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.1242/jcs.103.1.97",
      "volume": "103",
      "author": "Humbert C",
      "year": "1992",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b168",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(02)00452-9"
    },
    {
      "key": "b169",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-5793(86)81127-9"
    },
    {
      "key": "b170",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.107.5.1623"
    },
    {
      "key": "b171",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0014-4827(92)90308-U"
    },
    {
      "key": "b172",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.8.14.1627"
    },
    {
      "key": "b173",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00292709"
    },
    {
      "key": "b174",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00839.x"
    },
    {
      "key": "b175",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.94.21.11244"
    },
    {
      "key": "b176",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1989.tb03580.x"
    },
    {
      "key": "b177",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0022-2836(91)90207-M"
    },
    {
      "key": "b178",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00115a002"
    },
    {
      "key": "b179",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/20.4.735"
    },
    {
      "key": "b180",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0378-1119(93)90093-I"
    },
    {
      "key": "b181",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.4.2.145"
    },
    {
      "key": "b182",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/23.17.3493"
    },
    {
      "key": "b183",
      "doi-asserted-by": "publisher",
      "DOI": "10.1006/geno.1995.1229"
    },
    {
      "key": "b184",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/25.6.1094"
    },
    {
      "key": "b185",
      "doi-asserted-by": "crossref",
      "first-page": "21706",
      "DOI": "10.1016/S0021-9258(20)80599-7",
      "volume": "268",
      "author": "Brown WC",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b186",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.14.7988"
    },
    {
      "key": "b187",
      "doi-asserted-by": "crossref",
      "first-page": "16402",
      "DOI": "10.1016/S0021-9258(17)46237-5",
      "volume": "265",
      "author": "Goulian M",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b188",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.90.19.9105"
    },
    {
      "key": "b189",
      "doi-asserted-by": "crossref",
      "first-page": "1942",
      "DOI": "10.1016/S0021-9258(18)52384-X",
      "volume": "266",
      "author": "Melendy T",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b190",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.87.22.8692"
    },
    {
      "key": "b191",
      "doi-asserted-by": "crossref",
      "first-page": "7284",
      "DOI": "10.1016/S0021-9258(18)42517-3",
      "volume": "267",
      "author": "Eki T",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b192",
      "doi-asserted-by": "crossref",
      "first-page": "10923",
      "DOI": "10.1016/S0021-9258(17)34146-7",
      "volume": "269",
      "author": "Waga S",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b193",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi952455k"
    },
    {
      "key": "b194",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi9530649"
    },
    {
      "key": "b195",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1996.tb00583.x"
    },
    {
      "key": "b196",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(90)90391-Q"
    },
    {
      "key": "b197",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05106.x"
    },
    {
      "key": "b198",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.1.496"
    },
    {
      "key": "b199",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/21.4.841"
    },
    {
      "key": "b200",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.21.9803"
    },
    {
      "key": "b201",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bies.950190309"
    },
    {
      "key": "b202",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.8.11.1344"
    },
    {
      "key": "b203",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.7.4878"
    },
    {
      "key": "b204",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06373.x"
    },
    {
      "key": "b205",
      "doi-asserted-by": "crossref",
      "first-page": "19723",
      "DOI": "10.1016/S0021-9258(19)77695-9",
      "volume": "263",
      "author": "Ishimi Y",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b206",
      "doi-asserted-by": "crossref",
      "first-page": "18461",
      "DOI": "10.1016/S0021-9258(17)44775-2",
      "volume": "265",
      "author": "Goulian M",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b207",
      "doi-asserted-by": "crossref",
      "first-page": "28535",
      "DOI": "10.1016/S0021-9258(19)61935-6",
      "volume": "269",
      "author": "Robins P",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b208",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.20.9377"
    },
    {
      "key": "b209",
      "doi-asserted-by": "crossref",
      "first-page": "9801",
      "DOI": "10.1016/S0021-9258(19)81589-2",
      "volume": "263",
      "author": "Kenny MK",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b210",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/jb.177.2.364-371.1995"
    },
    {
      "key": "b211",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.9.4193"
    },
    {
      "key": "b212",
      "doi-asserted-by": "crossref",
      "first-page": "15136",
      "DOI": "10.1016/S0021-9258(18)82447-4",
      "volume": "268",
      "author": "Turchi JJ",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b213",
      "doi-asserted-by": "crossref",
      "first-page": "1191",
      "DOI": "10.1016/S0021-9258(17)42241-1",
      "volume": "269",
      "author": "Murante RS",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b214",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi9603074"
    },
    {
      "key": "b215",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.271.42.25888"
    },
    {
      "key": "b216",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.51.30377"
    },
    {
      "key": "b217",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi962890u"
    },
    {
      "key": "b218",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.7618086"
    },
    {
      "key": "b219",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81846-2"
    },
    {
      "key": "b220",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/ng0697-116"
    },
    {
      "key": "b221",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(00)81832-2"
    },
    {
      "key": "b222",
      "doi-asserted-by": "crossref",
      "first-page": "7353",
      "DOI": "10.1016/S0021-9258(18)50326-4",
      "volume": "254",
      "author": "Cathala G",
      "year": "1979",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b223",
      "doi-asserted-by": "crossref",
      "first-page": "9434",
      "DOI": "10.1016/S0021-9258(19)70581-X",
      "volume": "255",
      "author": "B\u00fcsen W",
      "year": "1980",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b224",
      "doi-asserted-by": "crossref",
      "first-page": "14764",
      "DOI": "10.1016/S0021-9258(17)38638-6",
      "volume": "260",
      "author": "DiFrancesco RA",
      "year": "1985",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b225",
      "doi-asserted-by": "publisher",
      "DOI": "10.1111/j.1432-1033.1989.tb15158.x"
    },
    {
      "key": "b226",
      "doi-asserted-by": "crossref",
      "first-page": "6472",
      "DOI": "10.1016/S0021-9258(18)38142-0",
      "volume": "266",
      "author": "Eder PS",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b227",
      "doi-asserted-by": "crossref",
      "first-page": "25922",
      "DOI": "10.1016/S0021-9258(18)47334-6",
      "volume": "269",
      "author": "Huang L",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b228",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.36.22591"
    },
    {
      "key": "b229",
      "unstructured": "Borowiec JA. 1996. See Ref.314, pp. 545\u201374"
    },
    {
      "key": "b230",
      "doi-asserted-by": "crossref",
      "first-page": "804",
      "DOI": "10.1128/jvi.66.2.804-815.1992",
      "volume": "66",
      "author": "Wessel R",
      "year": "1992",
      "journal-title": "J. Virol."
    },
    {
      "key": "b231",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.80.21.6465"
    },
    {
      "key": "b232",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.17.7642"
    },
    {
      "key": "b233",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.45.26766"
    },
    {
      "key": "b234",
      "doi-asserted-by": "publisher",
      "DOI": "10.1021/bi00024a016"
    },
    {
      "key": "b235",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/23.11.2014"
    },
    {
      "key": "b236",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.1.165"
    },
    {
      "key": "b237",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0968-0004(96)10013-X"
    },
    {
      "key": "b238",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/bies.950180305"
    },
    {
      "key": "b239",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/21.11.2541"
    },
    {
      "key": "b240",
      "doi-asserted-by": "publisher",
      "DOI": "10.1046/j.1365-2443.1997.1350333.x"
    },
    {
      "key": "b241",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(01)80009-X"
    },
    {
      "key": "b242",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.39.24508"
    },
    {
      "key": "b243",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/(SICI)1097-4644(19961201)63:3<259::AID-JCB1>3.0.CO;2-W"
    },
    {
      "key": "b244",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.4.2136"
    },
    {
      "key": "b245",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.7.4178"
    },
    {
      "key": "b246",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.12.12.5736"
    },
    {
      "key": "b247",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.12.12.5724"
    },
    {
      "key": "b248",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.89.4.1276"
    },
    {
      "key": "b249",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1093/genetics/124.1.81",
      "volume": "124",
      "author": "Prendergast JA",
      "year": "1990",
      "journal-title": "Genetics"
    },
    {
      "key": "b250",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.11.5710"
    },
    {
      "key": "b251",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.11.5718"
    },
    {
      "key": "b252",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.8.4291"
    },
    {
      "key": "b253",
      "doi-asserted-by": "publisher",
      "DOI": "10.1146/annurev.bi.61.070192.000415"
    },
    {
      "key": "b254",
      "unstructured": "Deleted in proof"
    },
    {
      "key": "b255",
      "doi-asserted-by": "crossref",
      "first-page": "11018",
      "DOI": "10.1016/S0021-9258(18)82087-7",
      "volume": "268",
      "author": "Murakami Y",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b256",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.6.11.4077"
    },
    {
      "key": "b257",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/329456a0"
    },
    {
      "key": "b258",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1990.tb07533.x"
    },
    {
      "key": "b259",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.2.809"
    },
    {
      "key": "b260",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.91.18.8700"
    },
    {
      "key": "b261",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.11.4.2108"
    },
    {
      "key": "b262",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.5.3176"
    },
    {
      "key": "b263",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.1.94"
    },
    {
      "key": "b264",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.13.5.2882"
    },
    {
      "key": "b265",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.14.8.5043"
    },
    {
      "key": "b266",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.15.1.173"
    },
    {
      "key": "b267",
      "doi-asserted-by": "crossref",
      "first-page": "13231",
      "DOI": "10.1016/S0021-9258(19)38289-4",
      "volume": "265",
      "author": "Goulian M",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b268",
      "doi-asserted-by": "crossref",
      "first-page": "13221",
      "DOI": "10.1016/S0021-9258(19)38288-2",
      "volume": "265",
      "author": "Goulian M",
      "year": "1990",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b269",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90650-F"
    },
    {
      "key": "b270",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90649-B"
    },
    {
      "key": "b271",
      "doi-asserted-by": "crossref",
      "first-page": "7469",
      "DOI": "10.1016/S0021-9258(17)34526-X",
      "volume": "253",
      "author": "Eliasson R",
      "year": "1978",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "b272",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1093/genetics/142.3.717",
      "volume": "142",
      "author": "Shcherbakova PV",
      "year": "1996",
      "journal-title": "Genetics"
    },
    {
      "key": "b273",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90448-4"
    },
    {
      "key": "b274",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.10.20.2632"
    },
    {
      "key": "b275",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.274.5293.1664"
    },
    {
      "key": "b276",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.93.14.7048"
    },
    {
      "key": "b277",
      "doi-asserted-by": "publisher",
      "DOI": "10.1073/pnas.92.25.11791"
    },
    {
      "key": "b278",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(93)90428-S"
    },
    {
      "key": "b279",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1994.tb06866.x"
    },
    {
      "key": "b280",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.11.24.3387"
    },
    {
      "key": "b281",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.5.2381"
    },
    {
      "key": "b282",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/emboj/16.3.639"
    },
    {
      "key": "b283",
      "doi-asserted-by": "crossref",
      "first-page": "3109",
      "DOI": "10.1242/jcs.108.9.3109",
      "volume": "108",
      "author": "D'Urso G",
      "year": "1995",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "b284",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF00298962"
    },
    {
      "key": "b285",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/374817a0"
    },
    {
      "key": "b286",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.17.10.5905"
    },
    {
      "key": "b287",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(95)90481-6"
    },
    {
      "key": "b288",
      "doi-asserted-by": "publisher",
      "DOI": "10.1002/j.1460-2075.1992.tb05618.x"
    },
    {
      "key": "b289",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.9.10.1149"
    },
    {
      "key": "b290",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.274.5293.1672"
    },
    {
      "key": "b291",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.7.8.1572"
    },
    {
      "key": "b292",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(00)00196-2"
    },
    {
      "key": "b293",
      "doi-asserted-by": "publisher",
      "DOI": "10.1083/jcb.130.4.755"
    },
    {
      "key": "b294",
      "doi-asserted-by": "publisher",
      "DOI": "10.1093/nar/20.10.2441"
    },
    {
      "key": "b295",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0092-8674(92)90416-A"
    },
    {
      "key": "b296",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/371534a0"
    },
    {
      "key": "b297",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(00)00244-X"
    },
    {
      "key": "b298",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/374386a0"
    },
    {
      "key": "b299",
      "first-page": "2281",
      "volume": "10",
      "author": "Goubin F",
      "year": "1995",
      "journal-title": "Oncogene"
    },
    {
      "key": "b300",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/375159a0"
    },
    {
      "key": "b301",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.270.29.17060"
    },
    {
      "key": "b302",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0960-9822(95)00058-3"
    },
    {
      "key": "b303",
      "first-page": "595",
      "volume": "12",
      "author": "Chen I-T",
      "year": "1996",
      "journal-title": "Oncogene"
    },
    {
      "key": "b304",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.9.4673"
    },
    {
      "key": "b305",
      "doi-asserted-by": "publisher",
      "DOI": "10.1074/jbc.272.4.2373"
    },
    {
      "key": "b306",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/sj.onc.1201072"
    },
    {
      "key": "b307",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.11.16.2090"
    },
    {
      "key": "b308",
      "doi-asserted-by": "publisher",
      "DOI": "10.1101/gad.11.16.2101"
    },
    {
      "key": "b309",
      "unstructured": "Greider CW, Collins K, Autexier C. 1996. See Ref.314, pp. 619\u201338"
    },
    {
      "key": "b310",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(85)80120-3"
    },
    {
      "key": "b311",
      "doi-asserted-by": "publisher",
      "DOI": "10.1128/MCB.16.9.4614"
    },
    {
      "key": "b312",
      "doi-asserted-by": "publisher",
      "DOI": "10.1091/mbc.8.11.2145"
    },
    {
      "key": "b313",
      "doi-asserted-by": "publisher",
      "DOI": "10.1126/science.274.5285.249"
    },
    {
      "key": "b314",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/S0092-8674(94)90362-X"
    },
    {
      "key": "b315",
      "volume-title": "DNA Replication in Eukaryotic Cells.",
      "author": "De Pamphilis ML",
      "year": "1996"
    }
  ],
  "container-title": "Annual Review of Biochemistry",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.67.1.721",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        10,
        5
      ]
    ],
    "date-time": "2021-10-05T13:44:40Z",
    "timestamp": 1633441480000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.annualreviews.org/doi/10.1146/annurev.biochem.67.1.721"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  },
  "references-count": 315,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1998,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.biochem.67.1.721"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.biochem.67.1.721",
  "relation": {},
  "ISSN": [
    "0066-4154",
    "1545-4509"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Biochem.",
  "published": {
    "date-parts": [
      [
        1998,
        6
      ]
    ]
  }
}