DOI: 10.1146/annurev.biochem.67.1.609. MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function

MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function

10.1146/annurev.biochem.67.1.609

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasion, and influence corneal transparency and neurite outgrowth. Additional roles, derived from studies of mutant animals, indicate that certain proteoglycans are essential to life whereas others might be redundant.The review focuses on the most recent genetic and molecular biological studies of the matrix proteoglycans, broadly defined as proteoglycans secreted into the pericellular matrix. Special emphasis is placed on the molecular organization of the protein core, the utilization of protein modules, the gene structure and transcriptional control, and the functional roles of the various proteoglycans. When possible, proteoglycans have been grouped into distinct gene families and subfamilies offering a simplified nomenclature based on their protein core design. The structure-function relationship of some paradigmatic proteoglycans is discussed in depth and novel aspects of their biology are examined.

Bibliography

Iozzo, R. V. (1998). MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function. Annual Review of Biochemistry, 67(1), 609â652.

Authors 1

Renato V. Iozzo (first)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:42 a.m.)
Deposited	2 years, 4 months ago (April 23, 2023, 2:50 p.m.)
Indexed	5 days, 13 hours ago (Aug. 21, 2025, 1:53 p.m.)
Issued	27 years, 2 months ago (June 1, 1998)
Published	27 years, 2 months ago (June 1, 1998)
Published Print	27 years, 2 months ago (June 1, 1998)

Funders 0

None

BibTeX

@article{Iozzo_1998, title={MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function}, volume={67}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.67.1.609}, DOI={10.1146/annurev.biochem.67.1.609}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Iozzo, Renato V.}, year={1998}, month=jun, pages={609–652} }

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  "abstract": "<jats:p>The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions. Proteoglycans act as tissue organizers, influence cell growth and the maturation of specialized tissues, play a role as biological filters and modulate growth-factor activities, regulate collagen fibrillogenesis and skin tensile strength, affect tumor cell growth and invasion, and influence corneal transparency and neurite outgrowth. Additional roles, derived from studies of mutant animals, indicate that certain proteoglycans are essential to life whereas others might be redundant.</jats:p><jats:p>The review focuses on the most recent genetic and molecular biological studies of the matrix proteoglycans, broadly defined as proteoglycans secreted into the pericellular matrix. Special emphasis is placed on the molecular organization of the protein core, the utilization of protein modules, the gene structure and transcriptional control, and the functional roles of the various proteoglycans. When possible, proteoglycans have been grouped into distinct gene families and subfamilies offering a simplified nomenclature based on their protein core design. The structure-function relationship of some paradigmatic proteoglycans is discussed in depth and novel aspects of their biology are examined.</jats:p>",
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