DOI: 10.1146/annurev.biochem.66.1.717. THE ATP SYNTHASE

THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE

10.1146/annurev.biochem.66.1.717

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

An X-ray structure of the F1 portion of the mitochondrial ATP synthase shows asymmetry and differences in nucleotide binding of the catalytic β subunits that support the binding change mechanism with an internal rotation of the γ subunit. Other structural and mutational probes of the F1 and F0 portions of the ATP synthase are reviewed, together with kinetic and other evaluations of catalytic site occupancy and behavior during hydrolysis or synthesis of ATP. Subunit function as related to proton translocation and rotational catalysis is considered. Physical demonstrations of the γ subunit rotation have been achieved. The findings have implications for other enzymatic catalyses.

Bibliography

Boyer, P. D. (1997). THE ATP SYNTHASEâA SPLENDID MOLECULAR MACHINE. Annual Review of Biochemistry, 66(1), 717â749.

Authors 1

Paul D. Boyer (first)

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Dates

Type	When
Created	23 years ago (July 27, 2002, 7:42 a.m.)
Deposited	3 years, 10 months ago (Oct. 5, 2021, 7:59 a.m.)
Indexed	1 day, 16 hours ago (Aug. 20, 2025, 9:14 a.m.)
Issued	28 years, 2 months ago (June 1, 1997)
Published	28 years, 2 months ago (June 1, 1997)
Published Print	28 years, 2 months ago (June 1, 1997)

Funders 0

None

BibTeX

@article{Boyer_1997, title={THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE}, volume={66}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.biochem.66.1.717}, DOI={10.1146/annurev.biochem.66.1.717}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Boyer, Paul D.}, year={1997}, month=jun, pages={717–749} }

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  },
  "references-count": 250,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          1997,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1146/annurev.biochem.66.1.717"
  ],
  "URL": "http://dx.doi.org/10.1146/annurev.biochem.66.1.717",
  "relation": {},
  "ISSN": [
    "0066-4154",
    "1545-4509"
  ],
  "subject": [],
  "container-title-short": "Annu. Rev. Biochem.",
  "published": {
    "date-parts": [
      [
        1997,
        6
      ]
    ]
  }
}