DOI: 10.1146/annurev.bi.65.070196.003223. DNA TOPOISOMERASES

DNA TOPOISOMERASES

10.1146/annurev.bi.65.070196.003223

Crossref journal-article

Annual Reviews

Annual Review of Biochemistry (22)

Abstract

The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes. Newly discovered members and recent biochemical and structural results are reviewed, and mechanistic implications of these results are summarized. The primary cellular functions of these enzymes, including their roles in replication, transcription, chromosome condensation, and the maintenance of genome stability, are then discussed. The review ends with a summary of the regulation of the cellular levels of these enzymes and a discussion of their association with other cellular proteins.

Bibliography

Wang, J. C. (1996). DNA TOPOISOMERASES. Annual Review of Biochemistry, 65(1), 635â692.

Authors 1

James C. Wang (first)

References 0 Referenced 1,720

None

Dates

Type	When
Created	22 years, 2 months ago (July 2, 2003, 1:56 a.m.)
Deposited	3 years, 11 months ago (Oct. 5, 2021, 5:07 a.m.)
Indexed	1 week, 2 days ago (Aug. 28, 2025, 8:18 a.m.)
Issued	29 years, 3 months ago (June 1, 1996)
Published	29 years, 3 months ago (June 1, 1996)
Published Print	29 years, 3 months ago (June 1, 1996)

Funders 0

None

BibTeX

@article{Wang_1996, title={DNA TOPOISOMERASES}, volume={65}, ISSN={1545-4509}, url={http://dx.doi.org/10.1146/annurev.bi.65.070196.003223}, DOI={10.1146/annurev.bi.65.070196.003223}, number={1}, journal={Annual Review of Biochemistry}, publisher={Annual Reviews}, author={Wang, James C.}, year={1996}, month=jun, pages={635–692} }

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