DOI: 10.1139/y95-192. Evolution off spontaneous activity in the developing rat superior colliculus

Evolution off spontaneous activity in the developing rat superior colliculus

10.1139/y95-192

Crossref journal-article

Canadian Science Publishing

Canadian Journal of Physiology and Pharmacology (155)

Abstract

During the first 10 days after birth in the rat there are a succession of major developmental stages in the retinotectal pathway. During most of this time, the only recordable event in the superior colliculus is spontaneous activity. We studied and characterized this spontaneous activity, hypothesizing that it could play an important role in pathway development. The spontaneous discharges are detectable on postnatal day 5 (P5). After P5, the number of spontaneously active cells per penetration increases up to P10, after which they decrease to adult-like levels by P14–P15. Between P5 and P10, the spontaneous discharges exhibit several patterns of activity, from constant firing to intermittent bursts with periods of quiescence, without any bearing to age. We isolated the retina and superior colliculus by injecting xylocaine onto the optic nerve and found no change in collicular activity. While this suggests that the spontaneous activity in the colliculus is independent of the retina at the ages studied, the opposite experiment, i.e., electrically stimulating the optic nerve, resulted in increased firing by collicular neurons, perhaps via nonclassical synaptic transmission. Finally, we compared interval histograms for spontaneously active cells between P5 and P15. The histograms suggest that at certain ages, spontaneous firing is more regular; moreover, these ages precede major functional advances, e.g., onset of numerous spontaneously firing cells at P6, the first response to optic nerve stimulation at P10, and the first light-evoked response at P12–P13. Our results support the hypothesis that spontaneous activity in the neonatal superior colliculus has a role in development of the retinotectal pathway, but the data also indicate that classical synaptic transmission is not involved.Key words: superior colliculus, spontaneous activity, development, rat.

Bibliography

Itaya, S. K., Fortin, S., & Molotchnikoff, S. (1995). Evolution off spontaneous activity in the developing rat superior colliculus. Canadian Journal of Physiology and Pharmacology, 73(9), 1372â1377.

Authors 3

Stephen K. Itaya (first)
Stephane Fortin (additional)
Stephane Molotchnikoff (additional)

References 13 Referenced 31

10.1152/jn.1953.16.1.1 / Neurophysiol. by Bishop G.H. (1953)
{'key': 'p_3/p_3_1', 'first-page': '255', 'volume': '36', 'author': 'Breher B.', 'year': '1983', 'journal-title': 'Lett.'} / Lett. by Breher B. (1983)
10.1113/jphysiol.1985.sp015725 / J. Physiol. (London) by Fitzgerald M. (1985)
10.1523/JNEUROSCI.13-01-00243.1993 / J. Neurosci. by Galli-Resta L. (1993)
10.1016/0165-3806(88)90087-9 / Bev. Brain Res. by Itaya S.K. (1988)
10.1002/cne.901650209 / J. Comp. Neurol. by Lund R.D. (1976)
10.1016/0006-8993(72)90038-8 / Brain Res. by Lund R.D. (1972)
10.1073/pnas.87.7.2861 / Proc. Natl. Acad. Sci. U.S.A. by Maffei L. (1998)
{'key': 'p_14/p_14_1', 'first-page': '3690', 'volume': '72', 'author': 'Mslotchnikoff', 'year': '1993', 'journal-title': 'Dev. Brain Res.'} / Dev. Brain Res. by Mslotchnikoff (1993)
10.1523/JNEUROSCI.06-12-03692.1986 / J. Neurosci. by O'Lary D.D.M. (1986)
10.1002/cne.902190309 / J. Comp. Neurol. by Perry V.H. (1983)
10.1016/0165-3806(82)90013-X / Dev. Brain Res. by Potts R.A. (1982)
10.1016/0896-6273(93)90122-8 / Neuron by Wong W.O.L. (1993)

Dates

Type	When
Created	14 years, 4 months ago (April 24, 2011, 5:04 a.m.)
Deposited	5 years, 8 months ago (Jan. 5, 2020, 10:39 a.m.)
Indexed	11 months, 4 weeks ago (Sept. 8, 2024, 4:58 p.m.)
Issued	30 years ago (Sept. 1, 1995)
Published	30 years ago (Sept. 1, 1995)
Published Print	30 years ago (Sept. 1, 1995)

Funders 0

None

BibTeX

@article{Itaya_1995, title={Evolution off spontaneous activity in the developing rat superior colliculus}, volume={73}, ISSN={1205-7541}, url={http://dx.doi.org/10.1139/y95-192}, DOI={10.1139/y95-192}, number={9}, journal={Canadian Journal of Physiology and Pharmacology}, publisher={Canadian Science Publishing}, author={Itaya, Stephen K. and Fortin, Stephane and Molotchnikoff, Stephane}, year={1995}, month=sep, pages={1372–1377} }

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  "abstract": "<jats:p> During the first 10 days after birth in the rat there are a succession of major developmental stages in the retinotectal pathway. During most of this time, the only recordable event in the superior colliculus is spontaneous activity. We studied and characterized this spontaneous activity, hypothesizing that it could play an important role in pathway development. The spontaneous discharges are detectable on postnatal day 5 (P5). After P5, the number of spontaneously active cells per penetration increases up to P10, after which they decrease to adult-like levels by P14\u2013P15. Between P5 and P10, the spontaneous discharges exhibit several patterns of activity, from constant firing to intermittent bursts with periods of quiescence, without any bearing to age. We isolated the retina and superior colliculus by injecting xylocaine onto the optic nerve and found no change in collicular activity. While this suggests that the spontaneous activity in the colliculus is independent of the retina at the ages studied, the opposite experiment, i.e., electrically stimulating the optic nerve, resulted in increased firing by collicular neurons, perhaps via nonclassical synaptic transmission. Finally, we compared interval histograms for spontaneously active cells between P5 and P15. The histograms suggest that at certain ages, spontaneous firing is more regular; moreover, these ages precede major functional advances, e.g., onset of numerous spontaneously firing cells at P6, the first response to optic nerve stimulation at P10, and the first light-evoked response at P12\u2013P13. Our results support the hypothesis that spontaneous activity in the neonatal superior colliculus has a role in development of the retinotectal pathway, but the data also indicate that classical synaptic transmission is not involved.Key words: superior colliculus, spontaneous activity, development, rat. </jats:p>",
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