DOI: 10.1139/y77-185. Neuronal depressant effects of diethylester derivatives of excitatory amino acids

Neuronal depressant effects of diethylester derivatives of excitatory amino acids

10.1139/y77-185

Crossref journal-article

Canadian Science Publishing

Canadian Journal of Physiology and Pharmacology (155)

Abstract

The effect of iontophoretically applied kainic acid diethylester (KDEE) on the firing rate of feline spinal interneurones was investigated and compared with the action of glutamic acid diethylester (GDEE) and aspartic acid diethylester (ADEE). All these esters reversibly reduced spontaneous neuronal firing and increased spike height, KDEE being the most active of this group. KDEE decreased responses to glutamate, acetylcholine, and peripheral field stimulation, showing that its depressant action is not due to a selective antagonism of an excitatory putative transmitter.

Bibliography

MacDonald, J. F., Nistri, A., & Padjen, A. L. (1977). Neuronal depressant effects of diethylester derivatives of excitatory amino acids. Canadian Journal of Physiology and Pharmacology, 55(6), 1387â1390.

Authors 3

J. F. MacDonald (first)
A. Nistri (additional)
A. L. Padjen (additional)

References 0 Referenced 13

None

Dates

Type	When
Created	14 years, 4 months ago (April 24, 2011, 4:51 a.m.)
Deposited	5 years, 7 months ago (Jan. 5, 2020, 11:21 a.m.)
Indexed	1 year, 10 months ago (Oct. 20, 2023, 2:20 p.m.)
Issued	47 years, 8 months ago (Dec. 1, 1977)
Published	47 years, 8 months ago (Dec. 1, 1977)
Published Print	47 years, 8 months ago (Dec. 1, 1977)

Funders 0

None

BibTeX

@article{MacDonald_1977, title={Neuronal depressant effects of diethylester derivatives of excitatory amino acids}, volume={55}, ISSN={1205-7541}, url={http://dx.doi.org/10.1139/y77-185}, DOI={10.1139/y77-185}, number={6}, journal={Canadian Journal of Physiology and Pharmacology}, publisher={Canadian Science Publishing}, author={MacDonald, J. F. and Nistri, A. and Padjen, A. L.}, year={1977}, month=dec, pages={1387–1390} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2023,
        10,
        20
      ]
    ],
    "date-time": "2023-10-20T18:20:45Z",
    "timestamp": 1697826045417
  },
  "reference-count": 0,
  "publisher": "Canadian Science Publishing",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1977,
            12,
            1
          ]
        ],
        "date-time": "1977-12-01T00:00:00Z",
        "timestamp": 249782400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1977,
        12,
        1
      ]
    ]
  },
  "abstract": "<jats:p> The effect of iontophoretically applied kainic acid diethylester (KDEE) on the firing rate of feline spinal interneurones was investigated and compared with the action of glutamic acid diethylester (GDEE) and aspartic acid diethylester (ADEE). All these esters reversibly reduced spontaneous neuronal firing and increased spike height, KDEE being the most active of this group. KDEE decreased responses to glutamate, acetylcholine, and peripheral field stimulation, showing that its depressant action is not due to a selective antagonism of an excitatory putative transmitter. </jats:p>",
  "DOI": "10.1139/y77-185",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2011,
        4,
        24
      ]
    ],
    "date-time": "2011-04-24T08:51:03Z",
    "timestamp": 1303635063000
  },
  "page": "1387-1390",
  "source": "Crossref",
  "is-referenced-by-count": 13,
  "title": "Neuronal depressant effects of diethylester derivatives of excitatory amino acids",
  "prefix": "10.1139",
  "volume": "55",
  "author": [
    {
      "given": "J. F.",
      "family": "MacDonald",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "A.",
      "family": "Nistri",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "A. L.",
      "family": "Padjen",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "155",
  "container-title": "Canadian Journal of Physiology and Pharmacology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nrcresearchpress.com/doi/pdf/10.1139/y77-185",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        1,
        5
      ]
    ],
    "date-time": "2020-01-05T16:21:02Z",
    "timestamp": 1578241262000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "http://www.nrcresearchpress.com/doi/10.1139/y77-185"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1977,
        12,
        1
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          1977,
          12,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1139/y77-185"
  ],
  "URL": "http://dx.doi.org/10.1139/y77-185",
  "relation": {},
  "ISSN": [
    "0008-4212",
    "1205-7541"
  ],
  "subject": [],
  "container-title-short": "Can. J. Physiol. Pharmacol.",
  "published": {
    "date-parts": [
      [
        1977,
        12,
        1
      ]
    ]
  }
}