DOI: 10.1139/y74-162. Depression of Corticospinal Cells by Various Purines and Pyrimidines

Depression of Corticospinal Cells by Various Purines and Pyrimidines

10.1139/y74-162

Crossref journal-article

Canadian Science Publishing

Canadian Journal of Physiology and Pharmacology (155)

Abstract

Microiontophoretically applied adenine nucleotides depressed the firing of corticospinal and other unidentified cerebral cortical neurones. Adenosine 3′,5′-cyclic monophosphate was less potent than the other adenine nucleotides. Guanine nucleotides shared this depressant activity, although they were less potent. Pyrimidine nucleotides and xanthine derivatives were largely devoid of depressant activity. Adenosine triphosphate had an additional excitant action on some neurones, but this effect was not observed with corticospinal cells.

Bibliography

Phillis, J. W., Kostopoulos, G. K., & Limacher, J. J. (1974). Depression of Corticospinal Cells by Various Purines and Pyrimidines. Canadian Journal of Physiology and Pharmacology, 52(6), 1226â1229.

Authors 3

J. W. Phillis (first)
G. K. Kostopoulos (additional)
J. J. Limacher (additional)

References 0 Referenced 132

None

Dates

Type	When
Created	14 years, 4 months ago (April 24, 2011, 4:49 a.m.)
Deposited	5 years, 8 months ago (Jan. 5, 2020, 11:21 a.m.)
Indexed	3 days, 10 hours ago (Sept. 4, 2025, 10 a.m.)
Issued	50 years, 9 months ago (Dec. 1, 1974)
Published	50 years, 9 months ago (Dec. 1, 1974)
Published Print	50 years, 9 months ago (Dec. 1, 1974)

Funders 0

None

BibTeX

@article{Phillis_1974, title={Depression of Corticospinal Cells by Various Purines and Pyrimidines}, volume={52}, ISSN={1205-7541}, url={http://dx.doi.org/10.1139/y74-162}, DOI={10.1139/y74-162}, number={6}, journal={Canadian Journal of Physiology and Pharmacology}, publisher={Canadian Science Publishing}, author={Phillis, J. W. and Kostopoulos, G. K. and Limacher, J. J.}, year={1974}, month=dec, pages={1226–1229} }

JSON

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