DOI: 10.1139/o06-072. γH2AX and its role in DNA double-strand break repairThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

γH2AX and its role in DNA double-strand break repairThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

10.1139/o06-072

Crossref journal-article

Canadian Science Publishing

Biochemistry and Cell Biology (155)

Abstract

One of the earliest responses to a DNA double-strand break (DSB) is the carboxy-terminal phosphorylation of budding yeast H2A (metazoan histone H2AX) to create γH2A (or γΗ2ΑX). This chromatin modification stretches more than tens of kilobases around the DSB and has been proposed to play numerous roles in break recognition and repair, although it may not be the primary signal for many of these events. Studies suggest that γH2A(X) has 2 more direct roles: (i) to recruit cohesin around the DSB, and (ii) to maintain a checkpoint arrest. Recent work has identified other factors, including chromatin remodelers and protein phosphatases, which target γH2A(X) and regulate DSB repair/recovery.

Bibliography

Fillingham, J., Keogh, M.-C., & Krogan, N. J. (2006). Î³H2AX and its role in DNA double-strand break repairThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journalâs usual peer review process. Biochemistry and Cell Biology, 84(4), 568â577.

Authors 3

Jeffrey Fillingham (first)
Michael-Christopher Keogh (additional)
Nevan J. Krogan (additional)

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Dates

Type	When
Created	19 years ago (Aug. 26, 2006, 4:43 p.m.)
Deposited	1 month, 3 weeks ago (July 2, 2025, 2:49 p.m.)
Indexed	5 days, 2 hours ago (Aug. 22, 2025, 12:47 a.m.)
Issued	19 years ago (Aug. 1, 2006)
Published	19 years ago (Aug. 1, 2006)
Published Print	19 years ago (Aug. 1, 2006)

Funders 0

None

BibTeX

@article{Fillingham_2006, title={γH2AX and its role in DNA double-strand break repairThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal’s usual peer review process.}, volume={84}, ISSN={1208-6002}, url={http://dx.doi.org/10.1139/o06-072}, DOI={10.1139/o06-072}, number={4}, journal={Biochemistry and Cell Biology}, publisher={Canadian Science Publishing}, author={Fillingham, Jeffrey and Keogh, Michael-Christopher and Krogan, Nevan J.}, year={2006}, month=aug, pages={568–577} }

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