DOI: 10.1139/o03-090. Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis

Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis

10.1139/o03-090

Crossref journal-article

Canadian Science Publishing

Biochemistry and Cell Biology (155)

Abstract

Sterol regulatory element binding proteins (SREBPs) are a family of membrane-bound transcription factors that play a unique and fundamental role in both cholesterol and fatty acid metabolism, relevant to human disease. There are three SREBPs that regulate the expression of over 30 genes. SREBPs are subject to regulation at three levels: proteolytic cleavage, rapid degradation by the ubiquitin-proteasome pathway, and sumoylation. Recently, there have been exciting advances in our understanding of the molecular mechanism of SREBP trafficking and processing with new information on the role of insulin-induced genes and the differential role and regulation of SREBP-1c and -2, which may ultimately lead to novel strategies for the treatment of dyslipidemia and insulin resistance.Key words: SREBP, Insig, SCAP, cholesterol synthesis, lipid metabolism.

Bibliography

McPherson, R., & Gauthier, A. (2004). Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis. Biochemistry and Cell Biology, 82(1), 201â211.

Authors 2

Ruth McPherson (first)
Andre Gauthier (additional)

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Dates

Type	When
Created	21 years, 5 months ago (April 2, 2004, 11:08 a.m.)
Deposited	2 months ago (July 2, 2025, 2:53 p.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 6:52 a.m.)
Issued	21 years, 7 months ago (Feb. 1, 2004)
Published	21 years, 7 months ago (Feb. 1, 2004)
Published Print	21 years, 7 months ago (Feb. 1, 2004)

Funders 0

None

BibTeX

@article{McPherson_2004, title={Molecular regulation of SREBP function: the Insig-SCAP connection and isoform-specific modulation of lipid synthesis}, volume={82}, ISSN={1208-6002}, url={http://dx.doi.org/10.1139/o03-090}, DOI={10.1139/o03-090}, number={1}, journal={Biochemistry and Cell Biology}, publisher={Canadian Science Publishing}, author={McPherson, Ruth and Gauthier, Andre}, year={2004}, month=feb, pages={201–211} }

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  "abstract": "<jats:p> Sterol regulatory element binding proteins (SREBPs) are a family of membrane-bound transcription factors that play a unique and fundamental role in both cholesterol and fatty acid metabolism, relevant to human disease. There are three SREBPs that regulate the expression of over 30 genes. SREBPs are subject to regulation at three levels: proteolytic cleavage, rapid degradation by the ubiquitin-proteasome pathway, and sumoylation. Recently, there have been exciting advances in our understanding of the molecular mechanism of SREBP trafficking and processing with new information on the role of insulin-induced genes and the differential role and regulation of SREBP-1c and -2, which may ultimately lead to novel strategies for the treatment of dyslipidemia and insulin resistance.Key words: SREBP, Insig, SCAP, cholesterol synthesis, lipid metabolism. </jats:p>",
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