DOI: 10.1139/o02-080. Dynamics of histone acetylation in vivo. A function for acetylation turnover?

Dynamics of histone acetylation in vivo. A function for acetylation turnover?

10.1139/o02-080

Crossref journal-article

Canadian Science Publishing

Biochemistry and Cell Biology (155)

Abstract

Histone acetylation, discovered more than 40 years ago, is a reversible modification of lysines within the amino-terminal domain of core histones. Amino-terminal histone domains contribute to the compaction of genes into repressed chromatin fibers. It is thought that their acetylation causes localized relaxation of chromatin as a necessary but not sufficient condition for processes that repackage DNA such as transcription, replication, repair, recombination, and sperm formation. While increased histone acetylation enhances gene transcription and loss of acetylation represses and silences genes, the function of the rapid continuous or repetitive acetylation and deacetylation reactions with half-lives of just a few minutes remains unknown. Thirty years of in vivo measurements of acetylation turnover and rates of change in histone modification levels have been reviewed to identify common chromatin characteristics measured by distinct protocols. It has now become possible to look across a wider spectrum of organisms than ever before and identify common features. The rapid turnover rates in transcriptionally active and competent chromatin are one such feature. While ubiquitously observed, we still do not know whether turnover itself is linked to chromatin transcription beyond its contribution to rapid changes towards hyper- or hypoacetylation of nucleosomes. However, recent experiments suggest that turnover may be linked directly to steps in gene transcription, interacting with nucleosome remodeling complexes.Key words: histone, acetylation, turnover, chromatin, transcription.

Bibliography

Waterborg, J. H. (2002). Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochemistry and Cell Biology, 80(3), 363â378.

Authors 1

Jakob H Waterborg (first)

References 147 Referenced 125

Rat hepatoma 70-15 6 mM butyrate, 20 h Coomassie Covault et al. 1982
Mouse T cells 5-10 40 ng TSA/mL, 4 h Western Taplick et al. 1998
Hamster CHO 15-2 15-2 5 mM butyrate, 24 h Coomassie Schröter et al. 1981
Human Iymphoma 28-4 5 mM butyrate, 24 h Coomassie Schröter et al. 1981
Human Iymphocytes 24-5 5 mM butyrate, 24 h Coomassie Schröter et al. 1981
Human Iung 18-1 5 mM butyrate, 24 h Coomassie Schröter et al. 1981
Human fibroblasts 15-3 5 mM butyrate, 24 h Coomassie Schröter et al. 1981
Human breast cancer 12-2 Ac4: 3 3 10 mM butyrate, 2 h 120-min label Sun et al. 2001
13-2 Ac4: 8 6 3-0.3 10 mM butyrate, 2 h 120-min label Sun et al. 2001
{'key': 'p_11/p_11_1', 'first-page': '1447', 'volume': '29', 'author': 'Allfrey V.G.', 'year': '1970', 'journal-title': 'Fed. Proc.'} / Fed. Proc. by Allfrey V.G. (1970)
Allfrey, V.G. 1977. Post-synthetic modifications of histone structure: a mechanism for the control of chromosome structure by the modulation of histone-DNA interactions. In Chromatin and chromosome structure. Edited by H.J. Li and R.A. Eckhardt. Academic Press, New York. p. 167. (10.1016/B978-0-12-450550-6.50010-5)
10.1016/S0091-679X(08)60578-6 / Methods Cell Biol. by Allfrey V.G. (1991)
10.1073/pnas.51.5.786 / Proc. Natl. Acad. Sci. U.S.A. by Allfrey V.G. (1964)
10.1073/pnas.82.23.8048 / Proc. Natl. Acad. Sci. U.S.A. by Allis C.D. (1985)
10.1093/nar/15.22.9325 / Nucleic Acids Res. by Alonso W.R. (1987)
Annunziato, A.T. 1995. Histone acetylation during chromatin replication and nucleosome assembly. In The nucleus: a multivolume treatise. Vol. 1. Edited by A. Wolffe. JAI Press, Greenwich, Conn. p. 31. (10.1016/B978-155938940-2/50015-8)
10.3727/000000001783992687 / Gene Expr. by Annunziato A.T. (2000)
10.1093/nar/11.5.1389 / Nucleic Acids Res. by Arrigo A.-P. (1983)
10.1021/bi00354a035 / Biochemistry by Ausio J. (1986)
10.1093/emboj/20.17.4944 / EMBO J. by Barbaric S. (2001)
10.1139/o01-032 / Biochem. Cell Biol. by Bertos N.R. (2001)
10.1016/S0092-8674(00)81532-9 / Cell by Bird A.P. (1999)
10.1111/j.1432-1033.1990.tb19474.x / Eur. J. Biochem. by Boffa L.C. (1990)
10.1074/jbc.272.42.26075 / J. Biol. Chem. by Bonifer C. (1997)
10.1093/emboj/20.12.3187 / EMBO J. by Brand M. (2001)
10.1093/nar/9.19.5061 / Nucleic Acids Res. by Brotherton T.W. (1981)
10.1016/S0021-9258(19)45115-6 / J. Biol. Chem. by Candido E.P.M. (1972)
10.1016/0092-8674(78)90305-7 / Cell by Candido E.P.M. (1978)
10.1016/S0021-9258(17)39664-3 / J. Biol. Chem. by Chalkley R. (1985)
10.1016/S0021-9258(18)38145-6 / J. Biol. Chem. by Chen T.A. (1991)
10.1073/pnas.76.1.46 / Proc. Natl. Acad. Sci. U.S.A. by Chestier A. (1979)
10.1016/S0021-9258(17)36054-4 / J. Biol. Chem. by Chicoine L.G. (1986)
10.1016/0012-1606(82)90127-0 / Dev. Biol. by Christensen M.E. (1982)
10.1074/jbc.M101650200 / J. Biol. Chem. by Christenson L.K. (2001)
10.1016/S0021-9258(18)34874-9 / J. Biol. Chem. by Cousens L.S. (1982)
10.1016/S0021-9258(17)37831-6 / J. Biol. Chem. by Cousens L.S. (1979)
10.1016/S0021-9258(19)70534-1 / J. Biol. Chem. by Covault J. (1980)
10.1016/S0021-9258(19)83850-4 / J. Biol. Chem. by Covault J. (1982)
10.1021/bi00553a019 / Biochemistry by D'Anna J.A. (1980)
10.1073/pnas.75.8.3574 / Proc. Natl. Acad. Sci. U.S.A. by Davie J.R. (1978)
10.1016/S0960-9822(01)00674-1 / Curr. Biol. by Davie J.K. (2002)
10.1128/MCB.21.8.2726-2735.2001 / Mol. Cell. Biol. by Deckert J. (2001)
10.1146/annurev.bi.40.070171.001431 / Rev. Biochem. by DeLange R.J. (1971)
10.1128/MCB.20.20.7541-7549.2000 / Mol. Cell. Biol. by DiRenzo J. (2000)
10.1016/0167-4889(83)90074-5 / Biochim. Biophys. Acta by Duncan M.R. (1983)
10.1016/0005-2787(73)90360-2 / Biochim. Biophys. Acta by Edwards G.S. (1973)
10.1128/MCB.16.12.7004 / Mol. Cell. Biol. by Erkine A.M. (1998)
10.1074/jbc.270.43.25359 / J. Biol. Chem. by Fletcher T.M. (1995)
10.1073/pnas.97.26.14494 / Proc. Natl. Acad. Sci. U.S.A. by Forsberg E.C. (2000)
10.1073/pnas.98.1.87 / Proc. Natl. Acad. Sci. U.S.A. by Furumai R. (2001)
10.1074/jbc.270.2.923 / J. Biol. Chem. by Garcia-Ramirez M. (1995)
10.1007/PL00000894 / Cell. Mol. Life Sci. by Graessle S. (2001)
10.1016/0014-4827(84)90232-5 / Exp. Cell Res. by Grimes S.R. (1984)
10.1146/annurev.bi.57.070188.001111 / Rev. Biochem. by Gross D.S. (1988)
10.1038/38664 / Nature (Lond.) by Grunstein M. (1997)
10.1078/0171-9335-00123 / Eur. J. Cell Biol. by Hazzouri M. (2000)
10.1002/j.1460-2075.1994.tb06451.x / EMBO J. by Hebbes T.R. (1994)
10.1016/S0021-9258(19)84449-6 / J. Biol. Chem. by Imai B.S. (1986)
{'key': 'p_60/p_60_1', 'first-page': '044', 'volume': '263', 'author': 'Ip Y.T.', 'year': '1988', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Ip Y.T. (1988)
10.1016/S0021-9258(19)41247-7 / J. Biol. Chem. by Jackson V. (1975)
10.1016/0022-2836(76)90282-5 / J. Mol. Biol. by Jackson V. (1976)
10.1007/s004120100132 / Chromosoma by Jasencakova Z. (2001)
Jenuwein, T., and Allis, C.D. 2001. Translating the histone code. Science (Washington, D.C.), 293: 1074-1080. (10.1126/science.1063127)
10.1016/0006-291X(81)91610-7 / Biochem. Biophys. Res. Commun. by Jiakuntorn Y. (1981)
10.1101/gad.967302 / Genes Dev. by Katan-Khaykovich Y. (2002)
10.1016/0378-1119(93)90560-P / Gene (Amst.) by Khochbin S. (1993)
10.1016/S0959-437X(00)00174-X / Curr. Opin. Genet. Dev. by Khochbin S. (2001)
10.1074/jbc.M100290200 / J. Biol. Chem. by Kruhlak M.J. (2001)
10.1038/383269a0 / Nature (Lond.) by Kuo M.-H. (1996)
10.1016/S1097-2765(00)00102-7 / Mol. Cell. by Kwon J. (2000)
10.1021/bi9918184 / Biochemistry by Lechner T. (2000)
10.1016/0014-5793(96)01033-2 / FEBS Lett. by Lee E. (1996)
10.1002/j.1460-2075.1991.tb07988.x / EMBO J. by Lee M.S. (1991)
10.1016/S0006-3495(98)77989-5 / Biophys. J. by Leuba S.H. (1998)
10.1016/S0006-3495(98)77990-1 / Biophys. J. by Leuba S.H. (1998)
10.1128/MCB.21.23.8213-8224.2001 / Mol. Cell. Biol. by Li J. (2001)
10.1093/emboj/20.9.2224 / EMBO J. by Litt M.D. (2001)
10.1016/0014-4827(82)90216-6 / Exp. Cell Res. by Littlefield B.A. (1982)
10.1242/jcs.58.1.303 / J. Cell Sci. by Loidl P. (1982)
10.1038/38444 / Nature (Lond.) by Luger K. (1997)
10.1007/PL00000893 / Cell. Mol. Life Sci. by Marmorstein R. (2001)
10.1023/A:1026747801728 / Chromosome Res. by Martinez-Lopez W. (2001)
10.1016/S0021-9258(18)62701-2 / J. Biol. Chem. by Marzluff W.F. (1970)
McMurry, M.T., and Krangel, M.S. 2000. A role for histone acetylation in the developmental regulation of V(D)J recombination. Science (Washington, D.C.), 287: 495-498. (10.1126/science.287.5452.495)
10.1002/mrd.1080310303 / Mol. Reprod. Dev. by Meistrich M.L. (1992)
10.1007/s000180050121 / Cell. Mol. Life Sci. by Mizzen C.A. (1998)
10.1016/0005-2787(79)90508-2 / Biochim. Biophys. Acta by Moore M. (1979)
10.1016/S0031-9422(00)00195-3 / Phytochemistry (Oxf.) by Murphy J.P. (2000)
{'key': 'p_90/p_90_1', 'first-page': '197', 'volume': '276', 'author': 'Myers F.A.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Myers F.A. (2001)
10.1016/S0021-9258(19)68068-3 / J. Biol. Chem. by Nelson D.A. (1982)
10.1007/PL00000892 / Cell. Mol. Life Sci. by Ogryzko V.V. (2001)
10.1093/nar/10.24.8049 / Nucleic Acids Res. by Oliva R. (1982)
10.1016/S1097-2765(00)80181-1 / Mol. Cell. by Parekh B.S. (1999)
10.1016/S0021-9258(19)69608-0 / J. Biol. Chem. by Perry M. (1981)
10.1016/S0021-9258(18)60422-3 / J. Biol. Chem. by Ramanathan B. (1989)
10.1104/pp.115.3.1021 / Plant Physiol. by Ransom R.F. (1997)
10.1016/S1097-2765(01)00200-3 / Mol. Cell. by Reinke H. (2001)
10.1242/jcs.114.15.2711 / J. Cell Sci. by Ridgway P. (2001)
10.1038/268462a0 / Nature (Lond.) by Riggs M.G. (1977)
10.1146/annurev.biochem.70.1.81 / Rev. Biochem. by Roth S.Y. (2001)
10.1073/pnas.260141297 / Proc. Natl. Acad. Sci. U.S.A. by Sachs L.M. (2000)
10.1074/jbc.274.49.34940 / J. Biol. Chem. by Sambucetti L.C. (1999)
10.1042/bj3030723 / Biochem. J. by Sanchez del Pino M.M. (1994)
10.1021/bi00729a001 / Biochemistry by Sanders L.A. (1973)
10.1111/j.1432-1033.1981.tb05664.x / Eur. J. Biochem. by Schröter H. (1981)
10.1093/nar/5.6.1863 / Nucleic Acids Res. by Sealy L. (1978)
10.1016/0092-8674(78)90306-9 / Cell by Sealy L. (1978)
10.1016/0092-8674(79)90063-1 / Cell by Seidman M.M. (1979)
10.1074/jbc.C100315200 / J. Biol. Chem. by Sheldon L.A. (2001)
10.1136/gut.46.4.507 / Gut by Siavoshian S. (2000)
{'key': 'p_112/p_112_1', 'first-page': '483', 'volume': '276', 'author': 'Smith E.R.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Smith E.R. (2001)
{'key': 'p_113/p_113_1', 'first-page': '810', 'volume': '276', 'author': 'Spencer V.A.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Spencer V.A. (2001)
10.1016/S0006-291X(87)80089-X / Biochem. Biophys. Res. Commun. by Staecker J.L. (1987)
10.1093/nar/15.11.4375 / Nucleic Acids Res. by Sterner R. (1987)
10.1038/47412 / Nature (Lond.) by Strahl B.D. (2000)
10.1016/S1097-2765(01)00301-X / Mol. Cell. by Suka N. (2001)
{'key': 'p_118/p_118_1', 'first-page': '435', 'volume': '276', 'author': 'Sun J.M.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Sun J.M. (2001)
10.1016/S0014-5793(98)01164-8 / FEBS Lett. by Taplick J. (1998)
10.1128/MCB.18.8.4629 / Mol. Cell. Biol. by Tse C. (1998)
10.1111/j.1432-1033.1989.tb14530.x / Eur. J. Biochem. by Turner B.M. (1989)
{'key': 'p_122/p_122_1', 'first-page': '245', 'volume': '5', 'author': 'Van Lint C.', 'year': '1996', 'journal-title': 'Gene Expr.'} / Gene Expr. by Van Lint C. (1996)
10.1073/pnas.75.5.2239 / Proc. Natl. Acad. Sci. U.S.A. by Vidali G. (1978)
10.1038/35044127 / Nature (Lond.) by Vogelauer M. (2000)
10.1016/S0968-0004(97)01016-5 / Trends Biochem. Sci. by Wade P.A. (1997)
10.1074/jbc.273.23.14516 / J. Biol. Chem. by Walia H. (1998)
10.1128/MCB.20.18.6904-6912.2000 / Mol. Cell. Biol. by Wang A.H. (2000)
{'key': 'p_128/p_128_1', 'first-page': '764', 'volume': '276', 'author': 'Wang X.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Wang X. (2001)
10.1016/0003-9861(72)90008-2 / Arch. Biochem. Biophys. by Wangh L. (1972)
10.1074/jbc.273.42.27602 / J. Biol. Chem. by Waterborg J.H. (1998)
10.1021/bi002480c / Biochemistry by Waterborg J.H. (2001)
{'key': 'p_132/p_132_1', 'first-page': '277', 'volume': '80', 'author': 'Waterborg J.H.', 'year': '2002', 'journal-title': 'Biochem. Cell Biol.'} / Biochem. Cell Biol. by Waterborg J.H. (2002)
10.1007/BF02788625 / Cell Biophys. by Waterborg J.H. (1983)
10.1021/bi00275a025 / Biochemistry by Waterborg J.H. (1983)
10.1111/j.1432-1033.1984.tb08290.x / Eur. J. Biochem. by Waterborg J.H. (1984)
10.1016/0167-4781(90)90105-B / Biochim. Biophys. Acta by Waterborg J.H. (1990)
10.1093/emboj/20.18.5207 / EMBO J. by White C.L. (2001)
{'key': 'p_138/p_138_1', 'first-page': '417', 'volume': '19', 'author': 'White D.A.', 'year': '1999', 'journal-title': 'Methods (Orlando)'} / Methods (Orlando) by White D.A. (1999)
10.1093/nar/25.20.3963 / Nucleic Acids Res. by Wilkins R.C. (1997)
10.1002/jcb.240210306 / J. Cell. Biochem. by Wintersberger E. (1983)
10.1016/S1097-2765(00)80194-X / Mol. Cell. by Wittschieben B.O. (1999)
Wolffe, A.P., and Matzke, M.A. 1999. Epigenetics: regulation through repression. Science (Washington, D.C.), 286: 481-486. (10.1126/science.286.5439.481)
10.3109/10409238609083735 / CRC Crit. Rev. Biochem. by Wu R.S. (1986)
10.1002/bies.950170510 / Bioessays by Yoshida M. (1995)
10.1042/bj2500233 / Biochem. J. by Zhang D.E. (1988)
10.1042/bj2500241 / Biochem. J. by Zhang D.E. (1988)
{'key': 'p_147/p_147_1', 'first-page': '042', 'volume': '276', 'author': 'Zhao X.', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Zhao X. (2001)
{'key': 'p_148/p_148_1', 'first-page': '256', 'volume': '275', 'author': 'Zhou Q.', 'year': '2000', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. by Zhou Q. (2000)

Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 6:58 a.m.)
Deposited	1 month, 4 weeks ago (July 2, 2025, 2:21 p.m.)
Indexed	1 week ago (Aug. 24, 2025, 6:49 p.m.)
Issued	23 years, 3 months ago (June 1, 2002)
Published	23 years, 3 months ago (June 1, 2002)
Published Print	23 years, 3 months ago (June 1, 2002)

Funders 0

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BibTeX

@article{Waterborg_2002, title={Dynamics of histone acetylation in vivo. A function for acetylation turnover?}, volume={80}, ISSN={1208-6002}, url={http://dx.doi.org/10.1139/o02-080}, DOI={10.1139/o02-080}, number={3}, journal={Biochemistry and Cell Biology}, publisher={Canadian Science Publishing}, author={Waterborg, Jakob H}, year={2002}, month=jun, pages={363–378} }

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  "abstract": "<jats:p> Histone acetylation, discovered more than 40 years ago, is a reversible modification of lysines within the amino-terminal domain of core histones. Amino-terminal histone domains contribute to the compaction of genes into repressed chromatin fibers. It is thought that their acetylation causes localized relaxation of chromatin as a necessary but not sufficient condition for processes that repackage DNA such as transcription, replication, repair, recombination, and sperm formation. While increased histone acetylation enhances gene transcription and loss of acetylation represses and silences genes, the function of the rapid continuous or repetitive acetylation and deacetylation reactions with half-lives of just a few minutes remains unknown. Thirty years of in vivo measurements of acetylation turnover and rates of change in histone modification levels have been reviewed to identify common chromatin characteristics measured by distinct protocols. It has now become possible to look across a wider spectrum of organisms than ever before and identify common features. The rapid turnover rates in transcriptionally active and competent chromatin are one such feature. While ubiquitously observed, we still do not know whether turnover itself is linked to chromatin transcription beyond its contribution to rapid changes towards hyper- or hypoacetylation of nucleosomes. However, recent experiments suggest that turnover may be linked directly to steps in gene transcription, interacting with nucleosome remodeling complexes.Key words: histone, acetylation, turnover, chromatin, transcription. </jats:p>",
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      "key": "p_16/p_16_1",
      "doi-asserted-by": "crossref",
      "first-page": "9325",
      "DOI": "10.1093/nar/15.22.9325",
      "volume": "15",
      "author": "Alonso W.R.",
      "year": "1987",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_17/p_17_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Annunziato, A.T. 1995. Histone acetylation during chromatin replication and nucleosome assembly. In The nucleus: a multivolume treatise. Vol. 1. Edited by A. Wolffe. JAI Press, Greenwich, Conn. p. 31.",
      "DOI": "10.1016/B978-155938940-2/50015-8"
    },
    {
      "key": "p_18/p_18_1",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.3727/000000001783992687",
      "volume": "9",
      "author": "Annunziato A.T.",
      "year": "2000",
      "journal-title": "Gene Expr."
    },
    {
      "key": "p_19/p_19_1",
      "doi-asserted-by": "crossref",
      "first-page": "1389",
      "DOI": "10.1093/nar/11.5.1389",
      "volume": "11",
      "author": "Arrigo A.-P.",
      "year": "1983",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_20/p_20_1",
      "doi-asserted-by": "crossref",
      "first-page": "1421",
      "DOI": "10.1021/bi00354a035",
      "volume": "25",
      "author": "Ausio J.",
      "year": "1986",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_21/p_21_1",
      "doi-asserted-by": "crossref",
      "first-page": "4944",
      "DOI": "10.1093/emboj/20.17.4944",
      "volume": "20",
      "author": "Barbaric S.",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_22/p_22_1",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1139/o01-032",
      "volume": "79",
      "author": "Bertos N.R.",
      "year": "2001",
      "journal-title": "Biochem. Cell Biol."
    },
    {
      "key": "p_23/p_23_1",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/S0092-8674(00)81532-9",
      "volume": "99",
      "author": "Bird A.P.",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "p_24/p_24_1",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.1111/j.1432-1033.1990.tb19474.x",
      "volume": "194",
      "author": "Boffa L.C.",
      "year": "1990",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "p_25/p_25_1",
      "doi-asserted-by": "crossref",
      "first-page": "075",
      "DOI": "10.1074/jbc.272.42.26075",
      "volume": "272",
      "author": "Bonifer C.",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_26/p_26_1",
      "doi-asserted-by": "crossref",
      "first-page": "3187",
      "DOI": "10.1093/emboj/20.12.3187",
      "volume": "20",
      "author": "Brand M.",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_27/p_27_1",
      "doi-asserted-by": "crossref",
      "first-page": "5061",
      "DOI": "10.1093/nar/9.19.5061",
      "volume": "9",
      "author": "Brotherton T.W.",
      "year": "1981",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_28/p_28_1",
      "doi-asserted-by": "crossref",
      "first-page": "3868",
      "DOI": "10.1016/S0021-9258(19)45115-6",
      "volume": "247",
      "author": "Candido E.P.M.",
      "year": "1972",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_29/p_29_1",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/0092-8674(78)90305-7",
      "volume": "14",
      "author": "Candido E.P.M.",
      "year": "1978",
      "journal-title": "Cell"
    },
    {
      "key": "p_30/p_30_1",
      "doi-asserted-by": "crossref",
      "first-page": "7698",
      "DOI": "10.1016/S0021-9258(17)39664-3",
      "volume": "260",
      "author": "Chalkley R.",
      "year": "1985",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_31/p_31_1",
      "doi-asserted-by": "crossref",
      "first-page": "6489",
      "DOI": "10.1016/S0021-9258(18)38145-6",
      "volume": "266",
      "author": "Chen T.A.",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_32/p_32_1",
      "doi-asserted-by": "crossref",
      "first-page": "46",
      "DOI": "10.1073/pnas.76.1.46",
      "volume": "76",
      "author": "Chestier A.",
      "year": "1979",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_33/p_33_1",
      "doi-asserted-by": "crossref",
      "first-page": "1071",
      "DOI": "10.1016/S0021-9258(17)36054-4",
      "volume": "261",
      "author": "Chicoine L.G.",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_34/p_34_1",
      "doi-asserted-by": "crossref",
      "first-page": "404",
      "DOI": "10.1016/0012-1606(82)90127-0",
      "volume": "93",
      "author": "Christensen M.E.",
      "year": "1982",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "p_35/p_35_1",
      "doi-asserted-by": "crossref",
      "first-page": "392",
      "DOI": "10.1074/jbc.M101650200",
      "volume": "276",
      "author": "Christenson L.K.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_36/p_36_1",
      "doi-asserted-by": "crossref",
      "first-page": "3945",
      "DOI": "10.1016/S0021-9258(18)34874-9",
      "volume": "257",
      "author": "Cousens L.S.",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_37/p_37_1",
      "doi-asserted-by": "crossref",
      "first-page": "1716",
      "DOI": "10.1016/S0021-9258(17)37831-6",
      "volume": "254",
      "author": "Cousens L.S.",
      "year": "1979",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_38/p_38_1",
      "doi-asserted-by": "crossref",
      "first-page": "9110",
      "DOI": "10.1016/S0021-9258(19)70534-1",
      "volume": "255",
      "author": "Covault J.",
      "year": "1980",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_39/p_39_1",
      "doi-asserted-by": "crossref",
      "first-page": "5809",
      "DOI": "10.1016/S0021-9258(19)83850-4",
      "volume": "257",
      "author": "Covault J.",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_40/p_40_1",
      "doi-asserted-by": "crossref",
      "first-page": "2656",
      "DOI": "10.1021/bi00553a019",
      "volume": "19",
      "author": "D'Anna J.A.",
      "year": "1980",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_41/p_41_1",
      "doi-asserted-by": "crossref",
      "first-page": "3574",
      "DOI": "10.1073/pnas.75.8.3574",
      "volume": "75",
      "author": "Davie J.R.",
      "year": "1978",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_42/p_42_1",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1016/S0960-9822(01)00674-1",
      "volume": "12",
      "author": "Davie J.K.",
      "year": "2002",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "p_43/p_43_1",
      "doi-asserted-by": "crossref",
      "first-page": "2726",
      "DOI": "10.1128/MCB.21.8.2726-2735.2001",
      "volume": "21",
      "author": "Deckert J.",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_44/p_44_1",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1146/annurev.bi.40.070171.001431",
      "volume": "40",
      "author": "DeLange R.J.",
      "year": "1971",
      "journal-title": "Rev. Biochem."
    },
    {
      "key": "p_45/p_45_1",
      "doi-asserted-by": "crossref",
      "first-page": "7541",
      "DOI": "10.1128/MCB.20.20.7541-7549.2000",
      "volume": "20",
      "author": "DiRenzo J.",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_46/p_46_1",
      "doi-asserted-by": "crossref",
      "first-page": "221",
      "DOI": "10.1016/0167-4889(83)90074-5",
      "volume": "762",
      "author": "Duncan M.R.",
      "year": "1983",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_47/p_47_1",
      "doi-asserted-by": "crossref",
      "first-page": "354",
      "DOI": "10.1016/0005-2787(73)90360-2",
      "volume": "199",
      "author": "Edwards G.S.",
      "year": "1973",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_48/p_48_1",
      "doi-asserted-by": "crossref",
      "first-page": "7004",
      "DOI": "10.1128/MCB.16.12.7004",
      "volume": "16",
      "author": "Erkine A.M.",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_49/p_49_1",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1074/jbc.270.43.25359",
      "volume": "270",
      "author": "Fletcher T.M.",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_50/p_50_1",
      "doi-asserted-by": "crossref",
      "first-page": "494",
      "DOI": "10.1073/pnas.97.26.14494",
      "volume": "97",
      "author": "Forsberg E.C.",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_51/p_51_1",
      "doi-asserted-by": "crossref",
      "first-page": "87",
      "DOI": "10.1073/pnas.98.1.87",
      "volume": "98",
      "author": "Furumai R.",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_52/p_52_1",
      "doi-asserted-by": "crossref",
      "first-page": "923",
      "DOI": "10.1074/jbc.270.2.923",
      "volume": "270",
      "author": "Garcia-Ramirez M.",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_53/p_53_1",
      "doi-asserted-by": "crossref",
      "first-page": "704",
      "DOI": "10.1007/PL00000894",
      "volume": "58",
      "author": "Graessle S.",
      "year": "2001",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "p_54/p_54_1",
      "doi-asserted-by": "crossref",
      "first-page": "91",
      "DOI": "10.1016/0014-4827(84)90232-5",
      "volume": "152",
      "author": "Grimes S.R.",
      "year": "1984",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "p_55/p_55_1",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1146/annurev.bi.57.070188.001111",
      "volume": "57",
      "author": "Gross D.S.",
      "year": "1988",
      "journal-title": "Rev. Biochem."
    },
    {
      "key": "p_56/p_56_1",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1038/38664",
      "volume": "389",
      "author": "Grunstein M.",
      "year": "1997",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_57/p_57_1",
      "doi-asserted-by": "crossref",
      "first-page": "950",
      "DOI": "10.1078/0171-9335-00123",
      "volume": "79",
      "author": "Hazzouri M.",
      "year": "2000",
      "journal-title": "Eur. J. Cell Biol."
    },
    {
      "key": "p_58/p_58_1",
      "doi-asserted-by": "crossref",
      "first-page": "1823",
      "DOI": "10.1002/j.1460-2075.1994.tb06451.x",
      "volume": "13",
      "author": "Hebbes T.R.",
      "year": "1994",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_59/p_59_1",
      "doi-asserted-by": "crossref",
      "first-page": "8784",
      "DOI": "10.1016/S0021-9258(19)84449-6",
      "volume": "261",
      "author": "Imai B.S.",
      "year": "1986",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_60/p_60_1",
      "first-page": "044",
      "volume": "263",
      "author": "Ip Y.T.",
      "year": "1988",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_61/p_61_1",
      "doi-asserted-by": "crossref",
      "first-page": "4856",
      "DOI": "10.1016/S0021-9258(19)41247-7",
      "volume": "250",
      "author": "Jackson V.",
      "year": "1975",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_62/p_62_1",
      "doi-asserted-by": "crossref",
      "first-page": "471",
      "DOI": "10.1016/0022-2836(76)90282-5",
      "volume": "104",
      "author": "Jackson V.",
      "year": "1976",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "p_63/p_63_1",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1007/s004120100132",
      "volume": "110",
      "author": "Jasencakova Z.",
      "year": "2001",
      "journal-title": "Chromosoma"
    },
    {
      "key": "p_64/p_64_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Jenuwein, T., and Allis, C.D. 2001. Translating the histone code. Science (Washington, D.C.), 293: 1074-1080.",
      "DOI": "10.1126/science.1063127"
    },
    {
      "key": "p_65/p_65_1",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.1016/0006-291X(81)91610-7",
      "volume": "102",
      "author": "Jiakuntorn Y.",
      "year": "1981",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "p_66/p_66_1",
      "doi-asserted-by": "crossref",
      "first-page": "743",
      "DOI": "10.1101/gad.967302",
      "volume": "16",
      "author": "Katan-Khaykovich Y.",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "p_67/p_67_1",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/0378-1119(93)90560-P",
      "volume": "128",
      "author": "Khochbin S.",
      "year": "1993",
      "journal-title": "Gene (Amst.)"
    },
    {
      "key": "p_68/p_68_1",
      "doi-asserted-by": "crossref",
      "first-page": "162",
      "DOI": "10.1016/S0959-437X(00)00174-X",
      "volume": "11",
      "author": "Khochbin S.",
      "year": "2001",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "p_69/p_69_1",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1074/jbc.M100290200",
      "volume": "276",
      "author": "Kruhlak M.J.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_70/p_70_1",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1038/383269a0",
      "volume": "383",
      "author": "Kuo M.-H.",
      "year": "1996",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_71/p_71_1",
      "doi-asserted-by": "crossref",
      "first-page": "1037",
      "DOI": "10.1016/S1097-2765(00)00102-7",
      "volume": "6",
      "author": "Kwon J.",
      "year": "2000",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "p_72/p_72_1",
      "doi-asserted-by": "crossref",
      "first-page": "1683",
      "DOI": "10.1021/bi9918184",
      "volume": "39",
      "author": "Lechner T.",
      "year": "2000",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_73/p_73_1",
      "doi-asserted-by": "crossref",
      "first-page": "183",
      "DOI": "10.1016/0014-5793(96)01033-2",
      "volume": "395",
      "author": "Lee E.",
      "year": "1996",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "p_74/p_74_1",
      "doi-asserted-by": "crossref",
      "first-page": "607",
      "DOI": "10.1002/j.1460-2075.1991.tb07988.x",
      "volume": "10",
      "author": "Lee M.S.",
      "year": "1991",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_75/p_75_1",
      "doi-asserted-by": "crossref",
      "first-page": "2823",
      "DOI": "10.1016/S0006-3495(98)77989-5",
      "volume": "74",
      "author": "Leuba S.H.",
      "year": "1998",
      "journal-title": "Biophys. J."
    },
    {
      "key": "p_76/p_76_1",
      "doi-asserted-by": "crossref",
      "first-page": "2830",
      "DOI": "10.1016/S0006-3495(98)77990-1",
      "volume": "74",
      "author": "Leuba S.H.",
      "year": "1998",
      "journal-title": "Biophys. J."
    },
    {
      "key": "p_77/p_77_1",
      "doi-asserted-by": "crossref",
      "first-page": "8213",
      "DOI": "10.1128/MCB.21.23.8213-8224.2001",
      "volume": "21",
      "author": "Li J.",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_78/p_78_1",
      "doi-asserted-by": "crossref",
      "first-page": "2224",
      "DOI": "10.1093/emboj/20.9.2224",
      "volume": "9",
      "author": "Litt M.D.",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_79/p_79_1",
      "doi-asserted-by": "crossref",
      "first-page": "283",
      "DOI": "10.1016/0014-4827(82)90216-6",
      "volume": "141",
      "author": "Littlefield B.A.",
      "year": "1982",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "p_80/p_80_1",
      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1242/jcs.58.1.303",
      "volume": "58",
      "author": "Loidl P.",
      "year": "1982",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "p_81/p_81_1",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1038/38444",
      "volume": "389",
      "author": "Luger K.",
      "year": "1997",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_82/p_82_1",
      "doi-asserted-by": "crossref",
      "first-page": "693",
      "DOI": "10.1007/PL00000893",
      "volume": "58",
      "author": "Marmorstein R.",
      "year": "2001",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "p_83/p_83_1",
      "doi-asserted-by": "crossref",
      "first-page": "69",
      "DOI": "10.1023/A:1026747801728",
      "volume": "9",
      "author": "Martinez-Lopez W.",
      "year": "2001",
      "journal-title": "Chromosome Res."
    },
    {
      "key": "p_84/p_84_1",
      "doi-asserted-by": "crossref",
      "first-page": "5635",
      "DOI": "10.1016/S0021-9258(18)62701-2",
      "volume": "245",
      "author": "Marzluff W.F.",
      "year": "1970",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_85/p_85_1",
      "doi-asserted-by": "crossref",
      "unstructured": "McMurry, M.T., and Krangel, M.S. 2000. A role for histone acetylation in the developmental regulation of V(D)J recombination. Science (Washington, D.C.), 287: 495-498.",
      "DOI": "10.1126/science.287.5452.495"
    },
    {
      "key": "p_86/p_86_1",
      "doi-asserted-by": "crossref",
      "first-page": "170",
      "DOI": "10.1002/mrd.1080310303",
      "volume": "31",
      "author": "Meistrich M.L.",
      "year": "1992",
      "journal-title": "Mol. Reprod. Dev."
    },
    {
      "key": "p_87/p_87_1",
      "doi-asserted-by": "crossref",
      "first-page": "6",
      "DOI": "10.1007/s000180050121",
      "volume": "54",
      "author": "Mizzen C.A.",
      "year": "1998",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "p_88/p_88_1",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1016/0005-2787(79)90508-2",
      "volume": "561",
      "author": "Moore M.",
      "year": "1979",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_89/p_89_1",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1016/S0031-9422(00)00195-3",
      "volume": "55",
      "author": "Murphy J.P.",
      "year": "2000",
      "journal-title": "Phytochemistry (Oxf.)"
    },
    {
      "key": "p_90/p_90_1",
      "first-page": "197",
      "volume": "276",
      "author": "Myers F.A.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_91/p_91_1",
      "doi-asserted-by": "crossref",
      "first-page": "1565",
      "DOI": "10.1016/S0021-9258(19)68068-3",
      "volume": "257",
      "author": "Nelson D.A.",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_92/p_92_1",
      "doi-asserted-by": "crossref",
      "first-page": "683",
      "DOI": "10.1007/PL00000892",
      "volume": "58",
      "author": "Ogryzko V.V.",
      "year": "2001",
      "journal-title": "Cell. Mol. Life Sci."
    },
    {
      "key": "p_93/p_93_1",
      "doi-asserted-by": "crossref",
      "first-page": "8049",
      "DOI": "10.1093/nar/10.24.8049",
      "volume": "10",
      "author": "Oliva R.",
      "year": "1982",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_94/p_94_1",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1016/S1097-2765(00)80181-1",
      "volume": "3",
      "author": "Parekh B.S.",
      "year": "1999",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "p_95/p_95_1",
      "doi-asserted-by": "crossref",
      "first-page": "3313",
      "DOI": "10.1016/S0021-9258(19)69608-0",
      "volume": "256",
      "author": "Perry M.",
      "year": "1981",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_96/p_96_1",
      "doi-asserted-by": "crossref",
      "first-page": "026",
      "DOI": "10.1016/S0021-9258(18)60422-3",
      "volume": "264",
      "author": "Ramanathan B.",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_97/p_97_1",
      "doi-asserted-by": "crossref",
      "first-page": "1021",
      "DOI": "10.1104/pp.115.3.1021",
      "volume": "115",
      "author": "Ransom R.F.",
      "year": "1997",
      "journal-title": "Plant Physiol."
    },
    {
      "key": "p_98/p_98_1",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1016/S1097-2765(01)00200-3",
      "volume": "7",
      "author": "Reinke H.",
      "year": "2001",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "p_99/p_99_1",
      "doi-asserted-by": "crossref",
      "first-page": "2711",
      "DOI": "10.1242/jcs.114.15.2711",
      "volume": "114",
      "author": "Ridgway P.",
      "year": "2001",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "p_100/p_100_1",
      "doi-asserted-by": "crossref",
      "first-page": "462",
      "DOI": "10.1038/268462a0",
      "volume": "268",
      "author": "Riggs M.G.",
      "year": "1977",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_101/p_101_1",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1146/annurev.biochem.70.1.81",
      "volume": "70",
      "author": "Roth S.Y.",
      "year": "2001",
      "journal-title": "Rev. Biochem."
    },
    {
      "key": "p_102/p_102_1",
      "doi-asserted-by": "crossref",
      "first-page": "138",
      "DOI": "10.1073/pnas.260141297",
      "volume": "97",
      "author": "Sachs L.M.",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_103/p_103_1",
      "doi-asserted-by": "crossref",
      "first-page": "940",
      "DOI": "10.1074/jbc.274.49.34940",
      "volume": "274",
      "author": "Sambucetti L.C.",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_104/p_104_1",
      "doi-asserted-by": "crossref",
      "first-page": "723",
      "DOI": "10.1042/bj3030723",
      "volume": "303",
      "author": "Sanchez del Pino M.M.",
      "year": "1994",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_105/p_105_1",
      "doi-asserted-by": "crossref",
      "first-page": "783",
      "DOI": "10.1021/bi00729a001",
      "volume": "12",
      "author": "Sanders L.A.",
      "year": "1973",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_106/p_106_1",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1111/j.1432-1033.1981.tb05664.x",
      "volume": "120",
      "author": "Schr\u00f6ter H.",
      "year": "1981",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "p_107/p_107_1",
      "doi-asserted-by": "crossref",
      "first-page": "1863",
      "DOI": "10.1093/nar/5.6.1863",
      "volume": "5",
      "author": "Sealy L.",
      "year": "1978",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_108/p_108_1",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1016/0092-8674(78)90306-9",
      "volume": "14",
      "author": "Sealy L.",
      "year": "1978",
      "journal-title": "Cell"
    },
    {
      "key": "p_109/p_109_1",
      "doi-asserted-by": "crossref",
      "first-page": "439",
      "DOI": "10.1016/0092-8674(79)90063-1",
      "volume": "18",
      "author": "Seidman M.M.",
      "year": "1979",
      "journal-title": "Cell"
    },
    {
      "key": "p_110/p_110_1",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1074/jbc.C100315200",
      "volume": "276",
      "author": "Sheldon L.A.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_111/p_111_1",
      "doi-asserted-by": "crossref",
      "first-page": "507",
      "DOI": "10.1136/gut.46.4.507",
      "volume": "46",
      "author": "Siavoshian S.",
      "year": "2000",
      "journal-title": "Gut"
    },
    {
      "key": "p_112/p_112_1",
      "first-page": "483",
      "volume": "276",
      "author": "Smith E.R.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_113/p_113_1",
      "first-page": "810",
      "volume": "276",
      "author": "Spencer V.A.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_114/p_114_1",
      "doi-asserted-by": "crossref",
      "first-page": "78",
      "DOI": "10.1016/S0006-291X(87)80089-X",
      "volume": "147",
      "author": "Staecker J.L.",
      "year": "1987",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "p_115/p_115_1",
      "doi-asserted-by": "crossref",
      "first-page": "4375",
      "DOI": "10.1093/nar/15.11.4375",
      "volume": "15",
      "author": "Sterner R.",
      "year": "1987",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_116/p_116_1",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1038/47412",
      "volume": "403",
      "author": "Strahl B.D.",
      "year": "2000",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_117/p_117_1",
      "doi-asserted-by": "crossref",
      "first-page": "473",
      "DOI": "10.1016/S1097-2765(01)00301-X",
      "volume": "8",
      "author": "Suka N.",
      "year": "2001",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "p_118/p_118_1",
      "first-page": "435",
      "volume": "276",
      "author": "Sun J.M.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_119/p_119_1",
      "doi-asserted-by": "crossref",
      "first-page": "349",
      "DOI": "10.1016/S0014-5793(98)01164-8",
      "volume": "436",
      "author": "Taplick J.",
      "year": "1998",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "p_120/p_120_1",
      "doi-asserted-by": "crossref",
      "first-page": "4629",
      "DOI": "10.1128/MCB.18.8.4629",
      "volume": "18",
      "author": "Tse C.",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_121/p_121_1",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1111/j.1432-1033.1989.tb14530.x",
      "volume": "179",
      "author": "Turner B.M.",
      "year": "1989",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "p_122/p_122_1",
      "first-page": "245",
      "volume": "5",
      "author": "Van Lint C.",
      "year": "1996",
      "journal-title": "Gene Expr."
    },
    {
      "key": "p_123/p_123_1",
      "doi-asserted-by": "crossref",
      "first-page": "2239",
      "DOI": "10.1073/pnas.75.5.2239",
      "volume": "75",
      "author": "Vidali G.",
      "year": "1978",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "p_124/p_124_1",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1038/35044127",
      "volume": "408",
      "author": "Vogelauer M.",
      "year": "2000",
      "journal-title": "Nature (Lond.)"
    },
    {
      "key": "p_125/p_125_1",
      "doi-asserted-by": "crossref",
      "first-page": "128",
      "DOI": "10.1016/S0968-0004(97)01016-5",
      "volume": "22",
      "author": "Wade P.A.",
      "year": "1997",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "p_126/p_126_1",
      "doi-asserted-by": "crossref",
      "first-page": "516",
      "DOI": "10.1074/jbc.273.23.14516",
      "volume": "273",
      "author": "Walia H.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_127/p_127_1",
      "doi-asserted-by": "crossref",
      "first-page": "6904",
      "DOI": "10.1128/MCB.20.18.6904-6912.2000",
      "volume": "20",
      "author": "Wang A.H.",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "p_128/p_128_1",
      "first-page": "764",
      "volume": "276",
      "author": "Wang X.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_129/p_129_1",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1016/0003-9861(72)90008-2",
      "volume": "150",
      "author": "Wangh L.",
      "year": "1972",
      "journal-title": "Arch. Biochem. Biophys."
    },
    {
      "key": "p_130/p_130_1",
      "doi-asserted-by": "crossref",
      "first-page": "602",
      "DOI": "10.1074/jbc.273.42.27602",
      "volume": "273",
      "author": "Waterborg J.H.",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_131/p_131_1",
      "doi-asserted-by": "crossref",
      "first-page": "2599",
      "DOI": "10.1021/bi002480c",
      "volume": "40",
      "author": "Waterborg J.H.",
      "year": "2001",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_132/p_132_1",
      "first-page": "277",
      "volume": "80",
      "author": "Waterborg J.H.",
      "year": "2002",
      "journal-title": "Biochem. Cell Biol."
    },
    {
      "key": "p_133/p_133_1",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1007/BF02788625",
      "volume": "5",
      "author": "Waterborg J.H.",
      "year": "1983",
      "journal-title": "Cell Biophys."
    },
    {
      "key": "p_134/p_134_1",
      "doi-asserted-by": "crossref",
      "first-page": "1489",
      "DOI": "10.1021/bi00275a025",
      "volume": "22",
      "author": "Waterborg J.H.",
      "year": "1983",
      "journal-title": "Biochemistry"
    },
    {
      "key": "p_135/p_135_1",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1111/j.1432-1033.1984.tb08290.x",
      "volume": "142",
      "author": "Waterborg J.H.",
      "year": "1984",
      "journal-title": "Eur. J. Biochem."
    },
    {
      "key": "p_136/p_136_1",
      "doi-asserted-by": "crossref",
      "first-page": "324",
      "DOI": "10.1016/0167-4781(90)90105-B",
      "volume": "1049",
      "author": "Waterborg J.H.",
      "year": "1990",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_137/p_137_1",
      "doi-asserted-by": "crossref",
      "first-page": "5207",
      "DOI": "10.1093/emboj/20.18.5207",
      "volume": "20",
      "author": "White C.L.",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "p_138/p_138_1",
      "first-page": "417",
      "volume": "19",
      "author": "White D.A.",
      "year": "1999",
      "journal-title": "Methods (Orlando)"
    },
    {
      "key": "p_139/p_139_1",
      "doi-asserted-by": "crossref",
      "first-page": "3963",
      "DOI": "10.1093/nar/25.20.3963",
      "volume": "25",
      "author": "Wilkins R.C.",
      "year": "1997",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "p_140/p_140_1",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1002/jcb.240210306",
      "volume": "21",
      "author": "Wintersberger E.",
      "year": "1983",
      "journal-title": "J. Cell. Biochem."
    },
    {
      "key": "p_141/p_141_1",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1016/S1097-2765(00)80194-X",
      "volume": "4",
      "author": "Wittschieben B.O.",
      "year": "1999",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "p_142/p_142_1",
      "doi-asserted-by": "crossref",
      "unstructured": "Wolffe, A.P., and Matzke, M.A. 1999. Epigenetics: regulation through repression. Science (Washington, D.C.), 286: 481-486.",
      "DOI": "10.1126/science.286.5439.481"
    },
    {
      "key": "p_143/p_143_1",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.3109/10409238609083735",
      "volume": "20",
      "author": "Wu R.S.",
      "year": "1986",
      "journal-title": "CRC Crit. Rev. Biochem."
    },
    {
      "key": "p_144/p_144_1",
      "doi-asserted-by": "crossref",
      "first-page": "423",
      "DOI": "10.1002/bies.950170510",
      "volume": "17",
      "author": "Yoshida M.",
      "year": "1995",
      "journal-title": "Bioessays"
    },
    {
      "key": "p_145/p_145_1",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1042/bj2500233",
      "volume": "250",
      "author": "Zhang D.E.",
      "year": "1988",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_146/p_146_1",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1042/bj2500241",
      "volume": "250",
      "author": "Zhang D.E.",
      "year": "1988",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_147/p_147_1",
      "first-page": "042",
      "volume": "276",
      "author": "Zhao X.",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "p_148/p_148_1",
      "first-page": "256",
      "volume": "275",
      "author": "Zhou Q.",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    }
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