DOI: 10.1139/g97-061. Three novel<i>T</i>-box genes in<i>Caenorhabditis elegans</i>

Three novelT-box genes inCaenorhabditis elegans

10.1139/g97-061

Crossref journal-article

Canadian Science Publishing

Genome (155)

Abstract

The T-box gene family consists of members that share a unique DNA binding domain. The best characterized T-box gene, Brachyury or T, encodes a transcription factor that plays an important role in early vertebrate development. Seven other recently described mouse T-box genes are also expressed during development. In the nematode Caenorhabditis elegans, four T-box genes have been characterized to date. In this study, we describe three new C. elegans T-box genes, named Ce-tbx-11, Ce-tbx-12, and Ce-tbx-17. Ce-tbx-11 and Ce-tbx-17 were uncovered through the sequencing efforts of the C. elegans Genome Project. Ce-tbx-12 was uncovered through degenerate PCR analysis of C. elegans genomic DNA. Ce-tbx-11 and Ce-tbx-17 are located in close proximity to the four other previously described T-box genes in the central region of chromosome III. In contrast, Ce-tbx-12 maps alone to chromosome II. Phylogenetic analysis of all known T-box domain sequences provides evidence of an ancient origin for this gene family.Key words: transcription factor, T-box genes, evolution, Brachyury.

Bibliography

Agulnik, S. I., Ruvinsky, I., & Silver, L. M. (1997). Three novelT-box genes inCaenorhabditis elegans. Genome, 40(4), 458â464.

Authors 3

Sergei I. Agulnik (first)
Ilya Ruvinsky (additional)
Lee M. Silver (additional)

References 15 Referenced 15

10.1016/0888-7543(95)80128-9 / Genomics by Agulnik S.I. (1995)
10.1093/genetics/144.1.249 / Genetics by Agulnik S.I. (1996)
10.1038/ng0794-383 / Nature Genet. by Bollag R.J. (1994)
10.1016/0896-6273(95)90065-9 / Neuron by Bulfone A. (1995)
10.1002/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO;2-F / Dev. Dyn. by Chapman D.L. (1996)
10.1016/0168-9525(90)90011-T / Trends Genet. by Henmann B.G. (1994)
10.1038/343617a0 / Nature (London) by Herrmann B.G. (1990)
10.1002/j.1460-2075.1993.tb05990.x / EMBO J. by Kispert A. (1993)
10.1101/gad.8.18.2137 / Genes Dev. by Kispert A. (1994)
10.1002/j.1460-2075.1995.tb00158.x / EMBO J. by Kispert A. (1995)
10.1016/0006-291X(92)90833-7 / Biochem. Biophys. Res. Cornrnun. by Pflugfelder G.O. (1992)
{'key': 'p_16/p_16_1', 'first-page': '945', 'volume': '9', 'author': 'Rzhetsky A.', 'year': '1992', 'journal-title': 'Mol. Biol. Evol.'} / Mol. Biol. Evol. by Rzhetsky A. (1992)
{'key': 'p_17/p_17_1', 'first-page': '409412', 'volume': '10', 'author': 'Rzhetsky A.', 'year': '1994', 'journal-title': 'Comput. Appl. Biosci.'} / Comput. Appl. Biosci. by Rzhetsky A. (1994)
{'key': 'p_18/p_18_1', 'first-page': '406', 'volume': '4', 'author': 'Saitou N.', 'year': '1987', 'journal-title': 'Mol. Biol. Evol.'} / Mol. Biol. Evol. by Saitou N. (1987)
10.1038/368032a0 / Nature (London) by Wilson R. (1994)

Dates

Type	When
Created	17 years, 3 months ago (May 8, 2008, 1:22 p.m.)
Deposited	3 years, 11 months ago (Sept. 9, 2021, 11:43 p.m.)
Indexed	1 year, 11 months ago (Sept. 13, 2023, 3:23 p.m.)
Issued	28 years, 1 month ago (Aug. 1, 1997)
Published	28 years, 1 month ago (Aug. 1, 1997)
Published Print	28 years, 1 month ago (Aug. 1, 1997)

Funders 0

None

BibTeX

@article{Agulnik_1997, title={Three novelT-box genes inCaenorhabditis elegans}, volume={40}, ISSN={1480-3321}, url={http://dx.doi.org/10.1139/g97-061}, DOI={10.1139/g97-061}, number={4}, journal={Genome}, publisher={Canadian Science Publishing}, author={Agulnik, Sergei I. and Ruvinsky, Ilya and Silver, Lee M.}, year={1997}, month=aug, pages={458–464} }

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  "abstract": "<jats:p>The T-box gene family consists of members that share a unique DNA binding domain. The best characterized T-box gene, Brachyury or T, encodes a transcription factor that plays an important role in early vertebrate development. Seven other recently described mouse T-box genes are also expressed during development. In the nematode Caenorhabditis elegans, four T-box genes have been characterized to date. In this study, we describe three new C. elegans T-box genes, named Ce-tbx-11, Ce-tbx-12, and Ce-tbx-17. Ce-tbx-11 and Ce-tbx-17 were uncovered through the sequencing efforts of the C. elegans Genome Project. Ce-tbx-12 was uncovered through degenerate PCR analysis of C. elegans genomic DNA. Ce-tbx-11 and Ce-tbx-17 are located in close proximity to the four other previously described T-box genes in the central region of chromosome III. In contrast, Ce-tbx-12 maps alone to chromosome II. Phylogenetic analysis of all known T-box domain sequences provides evidence of an ancient origin for this gene family.Key words: transcription factor, T-box genes, evolution, Brachyury.</jats:p>",
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