DOI: 10.1139/o06-069. From transcription to transport: emerging roles for nuclear myosin IThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

From transcription to transport: emerging roles for nuclear myosin IThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

10.1139/o06-069

Crossref journal-article

Canadian Science Publishing

Biochemistry and Cell Biology (155)

Abstract

Myosins are a superfamily of actin-activated ATPases that, in the cytoplasm, work together with actin as molecular motors. The presence of actin in the nucleus has been known for many years. The demonstration of a nuclear isoform of a myosin, nuclear myosin I (NMI), stimulated a great deal of interest in possible intranuclear motor functions of an acto–NMI complex. NMI has been shown to be involved in transcription by RNA polymerases I and II. In both cases, NMI interacts with the respective polymerase and is critically involved in the basic process of transcription. A recent study on intranuclear long-range chromosome movement has now demonstrated a role for NMI in the translocation of chromosome regions as well. Moreover, this movement is based on an active and directed process that is facilitated by an acto–NMI complex, establishing for the first time a functional role for a motor complex consisting of actin and a myosin in the nucleus.

Bibliography

Hofmann, W. A., Johnson, T., Klapczynski, M., Fan, J.-L., & de Lanerolle, P. (2006). From transcription to transport: emerging roles for nuclear myosin IThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journalâs usual peer review process. Biochemistry and Cell Biology, 84(4), 418â426.

Authors 5

Wilma A. Hofmann (first)
Terezina Johnson (additional)
Marcin Klapczynski (additional)
Ji-Lao Fan (additional)
Primal de Lanerolle (additional)

References 54 Referenced 52

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Dates

Type	When
Created	18 years, 11 months ago (Aug. 26, 2006, 4:43 p.m.)
Deposited	1 month, 3 weeks ago (July 2, 2025, 2:48 p.m.)
Indexed	1 month, 3 weeks ago (July 3, 2025, 12:17 a.m.)
Issued	19 years ago (Aug. 1, 2006)
Published	19 years ago (Aug. 1, 2006)
Published Print	19 years ago (Aug. 1, 2006)

Funders 0

None

BibTeX

@article{Hofmann_2006, title={From transcription to transport: emerging roles for nuclear myosin IThis paper is one of a selection of papers published in this Special Issue, entitled 27th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal’s usual peer review process.}, volume={84}, ISSN={1208-6002}, url={http://dx.doi.org/10.1139/o06-069}, DOI={10.1139/o06-069}, number={4}, journal={Biochemistry and Cell Biology}, publisher={Canadian Science Publishing}, author={Hofmann, Wilma A. and Johnson, Terezina and Klapczynski, Marcin and Fan, Ji-Lao and de Lanerolle, Primal}, year={2006}, month=aug, pages={418–426} }

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