DOI: 10.1128/jvi.74.10.4933-4937.2000. Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses

Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses

10.1128/jvi.74.10.4933-4937.2000

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Since the Marburg (MBG) and Ebola (EBO) viruses have sequence homology and cause similar diseases, we hypothesized that they associate with target cells by similar mechanisms. Pseudotype viruses prepared with a luciferase-containing human immunodeficiency virus type 1 backbone and packaged by the MBG virus or the Zaire subtype EBO virus glycoproteins (GP) mediated infection of a comparable wide range of mammalian cell types, and both were inhibited by ammonium chloride. In contrast, they exhibited differential sensitivities to treatment of target cells with tunicamycin, endoglycosidase H, or protease (pronase). Therefore, while they exhibit certain functional similarities, the MBG and EBO virus GP interact with target cells by distinct processes.

Bibliography

Chan, S. Y., Speck, R. F., Ma, M. C., & Goldsmith, M. A. (2000). Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses. Journal of Virology, 74(10), 4933â4937.

Authors 4

Stephen Y. Chan (first)
Roberto F. Speck (additional)
Melissa C. Ma (additional)
Mark A. Goldsmith (additional)

References 19 Referenced 119

10.1128/JVI.73.3.2350-2358.1999
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10.1128/jvi.65.1.162-169.1991
10.1073/pnas.96.6.2662
Mar'iankova R., Glushakova S., Pyzhik E., Lukashevich I.The penetration of the Marburg virus into eukaryotic cells.Vopr. Virusol.3819937476 / Vopr. Virusol. / The penetration of the Marburg virus into eukaryotic cells. by Mar'iankova R. (1993)
Peters C. Sanchez A. Rollin P. Ksiazek T. Murphy F.Filoviridae: Marburg and Ebola viruses Fields virology 3rd ed. Fields B. N. Knipe D. M. Howley P. M.199611611176Lippincott-Raven PublishersPhiladelphia Pa
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Dates

Type	When
Created	23 years, 1 month ago (July 27, 2002, 6:06 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 11:05 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 5:06 a.m.)
Issued	25 years, 3 months ago (May 15, 2000)
Published	25 years, 3 months ago (May 15, 2000)
Published Print	25 years, 3 months ago (May 15, 2000)

Funders 0

None

BibTeX

@article{Chan_2000, title={Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses}, volume={74}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.74.10.4933-4937.2000}, DOI={10.1128/jvi.74.10.4933-4937.2000}, number={10}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Chan, Stephen Y. and Speck, Roberto F. and Ma, Melissa C. and Goldsmith, Mark A.}, year={2000}, month=may, pages={4933–4937} }

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