Abstract
Human foamy virus (HFV) is a retrovirus of the spumavirus family. We have constructed vectors based on HFV that encode neomycin phosphotransferase and alkaline phosphatase. These vectors are able to transduce a wide variety of vertebrate cells by integration of the vector genome. Unlike vectors based on murine leukemia virus, HFV vectors are not inactivated by human serum, and they transduce stationary-phase cultures more efficiently than murine leukemia virus vectors. These properties, as well as their large packaging capacity, make HFV vectors promising gene transfer vehicles.
Dates
Type | When |
---|---|
Created | 5 years, 8 months ago (Jan. 6, 2020, 4:37 p.m.) |
Deposited | 3 years, 6 months ago (March 5, 2022, 8:17 a.m.) |
Indexed | 4 months, 3 weeks ago (April 11, 2025, 7:28 a.m.) |
Issued | 29 years, 8 months ago (Jan. 1, 1996) |
Published | 29 years, 8 months ago (Jan. 1, 1996) |
Published Print | 29 years, 8 months ago (Jan. 1, 1996) |
@article{Russell_1996, title={Foamy virus vectors}, volume={70}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.70.1.217-222.1996}, DOI={10.1128/jvi.70.1.217-222.1996}, number={1}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Russell, D W and Miller, A D}, year={1996}, month=jan, pages={217–222} }