DOI: 10.1128/jvi.66.10.6213-6219.1992. Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

10.1128/jvi.66.10.6213-6219.1992

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Human immunodeficiency virus type 1 (HIV-1) can establish a persistent and latent infection in CD4+ T lymphocytes (W. C. Greene, N. Engl. J. Med. 324:308-317, 1991; S. M. Schnittman, M. C. Psallidopoulos, H. C. Lane, L. Thompson, M. Baseler, F. Massari, C. H. Fox, N. P. Salzman, and A. S. Fauci, Science 245:305-308, 1989). Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T. Folks, D. M. Powell, M. M. Lightfoote, S. Benn, M. A. Martin, and A. S. Fauci, Science 231:600-602, 1986; D. Zagury, J. Bernard, R. Leonard, R. Cheynier, M. Feldman, P. S. Sarin, and R. C. Gallo, Science 231:850-853, 1986). This activation is mediated by the host transcription factor NF-kappa B [G. Nabel and D. Baltimore, Nature (London) 326:711-717, 1987]. We report here that the HIV-1-encoded Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens. However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT. Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site. These results indicate that defective recruitment of NF-kappa B may underlie Nef's negative transcriptional effects on the HIV-1 and interleukin 2 promoters. Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.

Bibliography

Niederman, T. M., Garcia, J. V., Hastings, W. R., Luria, S., & Ratner, L. (1992). Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells. Journal of Virology, 66(10), 6213â6219.

Authors 5

T M Niederman (first)
J V Garcia (additional)
W R Hastings (additional)
S Luria (additional)
L Ratner (additional)

References 0 Referenced 97

None

Dates

Type	When
Created	5 years, 8 months ago (Jan. 6, 2020, 11:15 a.m.)
Deposited	3 years, 6 months ago (March 4, 2022, 7:35 p.m.)
Indexed	4 months, 4 weeks ago (April 8, 2025, 10:01 p.m.)
Issued	32 years, 11 months ago (Oct. 1, 1992)
Published	32 years, 11 months ago (Oct. 1, 1992)
Published Print	32 years, 11 months ago (Oct. 1, 1992)

Funders 0

None

BibTeX

@article{Niederman_1992, title={Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells}, volume={66}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.66.10.6213-6219.1992}, DOI={10.1128/jvi.66.10.6213-6219.1992}, number={10}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Niederman, T M and Garcia, J V and Hastings, W R and Luria, S and Ratner, L}, year={1992}, month=oct, pages={6213–6219} }

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  "abstract": "<jats:p>Human immunodeficiency virus type 1 (HIV-1) can establish a persistent and latent infection in CD4+ T lymphocytes (W. C. Greene, N. Engl. J. Med. 324:308-317, 1991; S. M. Schnittman, M. C. Psallidopoulos, H. C. Lane, L. Thompson, M. Baseler, F. Massari, C. H. Fox, N. P. Salzman, and A. S. Fauci, Science 245:305-308, 1989). Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T. Folks, D. M. Powell, M. M. Lightfoote, S. Benn, M. A. Martin, and A. S. Fauci, Science 231:600-602, 1986; D. Zagury, J. Bernard, R. Leonard, R. Cheynier, M. Feldman, P. S. Sarin, and R. C. Gallo, Science 231:850-853, 1986). This activation is mediated by the host transcription factor NF-kappa B [G. Nabel and D. Baltimore, Nature (London) 326:711-717, 1987]. We report here that the HIV-1-encoded Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens. However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT. Additionally, Nef inhibits the induction of HIV-1- and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site. These results indicate that defective recruitment of NF-kappa B may underlie Nef's negative transcriptional effects on the HIV-1 and interleukin 2 promoters. Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.</jats:p>",
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