DOI: 10.1128/jvi.65.11.6349-6352.1991. Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity

Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity

10.1128/jvi.65.11.6349-6352.1991

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

All animal retroviruses whose nucleotide sequences have been determined contain two or three closely spaced cysteine residues in the extracellular domain of the env-encoded transmembrane protein. Using human immunodeficiency virus type 1 gp41 as a working model, the functional significance of these highly conserved cysteines was investigated. We report here that substituting the two conserved cysteine residues in this domain of gp41 with glycine residues resulted in the loss of viral infectivity, which could be attributed to severe impairment in the processing of gp160 precursor to gp120.

Bibliography

Syu, W. J., Lee, W. R., Du, B., Yu, Q. C., Essex, M., & Lee, T. H. (1991). Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. Journal of Virology, 65(11), 6349â6352.

Authors 6

W J Syu (first)
W R Lee (additional)
B Du (additional)
Q C Yu (additional)
M Essex (additional)
T H Lee (additional)

References 0 Referenced 45

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 6, 2020, 11 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 7:14 p.m.)
Indexed	11 months, 1 week ago (Sept. 9, 2024, 1:56 a.m.)
Issued	33 years, 9 months ago (Nov. 1, 1991)
Published	33 years, 9 months ago (Nov. 1, 1991)
Published Print	33 years, 9 months ago (Nov. 1, 1991)

Funders 0

None

BibTeX

@article{Syu_1991, title={Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity}, volume={65}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.65.11.6349-6352.1991}, DOI={10.1128/jvi.65.11.6349-6352.1991}, number={11}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Syu, W J and Lee, W R and Du, B and Yu, Q C and Essex, M and Lee, T H}, year={1991}, month=nov, pages={6349–6352} }

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