DOI: 10.1128/jvi.64.6.2819-2824.1990. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification

10.1128/jvi.64.6.2819-2824.1990

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Primary duck hepatocytes were infected with a mutant duck hepatitis B virus defective in envelope protein but competent for viral DNA synthesis. Cells infected by this mutant accumulated higher levels of viral covalently closed, circular DNA (cccDNA) than those infected by wild-type virus. The accumulation of high levels of cccDNA was due to a failure of the mutant-infected cells to suppress de novo cccDNA synthesis compared with suppression by cells infected by the wild type. The envelope-defective virus failed to establish a persistent infection in vitro, possibly because of a virus-mediated cell death. Therefore, one or both viral envelope proteins are required for regulation of cccDNA synthesis and for maintenance of persistent infection in vitro.

Bibliography

Summers, J., Smith, P. M., & Horwich, A. L. (1990). Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. Journal of Virology, 64(6), 2819â2824.

Authors 3

J Summers (first)
P M Smith (additional)
A L Horwich (additional)

References 0 Referenced 281

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 6, 2020, 10:50 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 7:01 p.m.)
Indexed	3 months, 1 week ago (May 26, 2025, 1:28 p.m.)
Issued	35 years, 3 months ago (June 1, 1990)
Published	35 years, 3 months ago (June 1, 1990)
Published Print	35 years, 3 months ago (June 1, 1990)

Funders 0

None

BibTeX

@article{Summers_1990, title={Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification}, volume={64}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.64.6.2819-2824.1990}, DOI={10.1128/jvi.64.6.2819-2824.1990}, number={6}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Summers, J and Smith, P M and Horwich, A L}, year={1990}, month=jun, pages={2819–2824} }

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