DOI: 10.1128/jvi.55.3.521-526.1985. Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity

Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity

10.1128/jvi.55.3.521-526.1985

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

Both FBJ murine osteosarcoma virus (FBJ-MSV) and FBR-MSV induce transformation in tissue culture and osteogenic sarcomas in mice. In tissue culture, however, FBR-MSV induces larger foci with a shorter latency than those induced by FBJ-MSV. Transformation is dependent on expression of the fos oncogene in FBJ-MSV and of a gag-fos fusion protein in FBR-MSV. We have determined that the gag sequences can be deleted from FBR-MSV without affecting the high transforming activity of this virus in comparison to FBJ-MSV. The resultant virus, designated FBJ/R-MSV, has a protein coding region that is half the size of that of FBR-MSV and about one-third smaller than that of FBJ-MSV. Thus, FBJ/R-MSV will provide a useful tool for studying the transforming activity of the fos oncogene.

Bibliography

Miller, A. D., Verma, I. M., & Curran, T. (1985). Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity. Journal of Virology, 55(3), 521â526.

Authors 3

A D Miller (first)
I M Verma (additional)
T Curran (additional)

References 0 Referenced 22

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 6, 2020, 9:26 a.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 6:03 p.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 11 p.m.)
Issued	40 years ago (Sept. 1, 1985)
Published	40 years ago (Sept. 1, 1985)
Published Print	40 years ago (Sept. 1, 1985)

Funders 0

None

BibTeX

@article{Miller_1985, title={Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity}, volume={55}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.55.3.521-526.1985}, DOI={10.1128/jvi.55.3.521-526.1985}, number={3}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Miller, A D and Verma, I M and Curran, T}, year={1985}, month=sep, pages={521–526} }

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