DOI: 10.1128/jvi.43.1.26-36.1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus

Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus

10.1128/jvi.43.1.26-36.1982

Crossref journal-article

American Society for Microbiology

Journal of Virology (235)

Abstract

The endogenous ecotropic murine leukemia virus DNA content and integration sites were characterized for 54 inbred strains and substrains of mice by restriction enzyme digestion, Southern blotting, and hybridization with an ecotropic murine leukemia virus DNA-specific probe. More than 75% of these strains carried endogenous ecotropic proviruses which were located in at least 29 distinct integration sites in chromosomes of Mus musculus. Fourteen of these proviruses have been assigned specific locus designations. Most, but not all, of the endogenous ecotropic proviruses were structurally indistinguishable by this analysis from the prototype AKR ecotropic virus, and the distribution of these proviruses followed known relationships among the inbred strains and substrains of mice. These results suggest that, in general, viral DNA integration preceded the establishment of inbred mouse strains and that these integrations are relatively stable.

Bibliography

Jenkins, N. A., Copeland, N. G., Taylor, B. A., & Lee, B. K. (1982). Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. Journal of Virology, 43(1), 26â36.

Authors 4

N A Jenkins (first)
N G Copeland (additional)
B A Taylor (additional)
B K Lee (additional)

References 0 Referenced 477

None

Dates

Type	When
Created	5 years, 7 months ago (Jan. 5, 2020, 8:18 p.m.)
Deposited	3 years, 5 months ago (March 4, 2022, 5:42 p.m.)
Indexed	1 month, 2 weeks ago (July 12, 2025, 6:47 p.m.)
Issued	43 years, 1 month ago (July 1, 1982)
Published	43 years, 1 month ago (July 1, 1982)
Published Print	43 years, 1 month ago (July 1, 1982)

Funders 0

None

BibTeX

@article{Jenkins_1982, title={Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus}, volume={43}, ISSN={1098-5514}, url={http://dx.doi.org/10.1128/jvi.43.1.26-36.1982}, DOI={10.1128/jvi.43.1.26-36.1982}, number={1}, journal={Journal of Virology}, publisher={American Society for Microbiology}, author={Jenkins, N A and Copeland, N G and Taylor, B A and Lee, B K}, year={1982}, month=jul, pages={26–36} }

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