DOI: 10.1128/jb.95.5.1672-1679.1968. Isoleucine and Valine Metabolism of <i>Escherichia coli</i> XV. Biochemical Properties of Mutants Resistant to Thiaisoleucine

Isoleucine and Valine Metabolism of Escherichia coli XV. Biochemical Properties of Mutants Resistant to Thiaisoleucine

10.1128/jb.95.5.1672-1679.1968

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Thiaisoleucine-resistant mutants of Escherichia coli strain K-12 which exhibited reduced isoleucyl soluble ribonucleic acid synthetase activity were isolated. Resistance was apparently achieved by the selection of a synthetase with a 10-fold decrease in apparent affinity for thiaisoleucine. This mutation also resulted in a 2.5-fold decrease in apparent affinity for the natural substrate, l -isoleucine, and less activity than found in wild type. The mutants grew more slowly than wild type and were derepressed for three of the five enzymes in the pathways to isoleucine and valine.

Bibliography

Szentirmai, A., Szentirmai, M., & Umbarger, H. E. (1968). Isoleucine and Valine Metabolism of Escherichia coli XV. Biochemical Properties of Mutants Resistant to Thiaisoleucine. Journal of Bacteriology, 95(5), 1672â1679.

Authors 3

A. Szentirmai (first)
M. Szentirmai (additional)
H. E. Umbarger (additional)

References 17 Referenced 98

BOCK , A., L. E. FAIMAN , A ND F . C. NEIDHARDT. 1966 . Biochemical and genetic characterization of a mutant of Escherichia coli with a temperature-sensitive valyl ribonucleic acid synthetase . J. Bacteriol. 92 : 1076 - 1082 . (10.1128/JB.92.4.1076-1082.1966) / J. Bacteriol. / Biochemical and genetic characterization of a mutant of Escherichia coli with a temperature-sensitive valyl ribonucleic acid synthetase by BOCK A., L. (1966)
DIXON , M. 1933 . The determination of enzyme inhibitor constants . Biochem. J. 55 : 170 - 171 . (10.1042/bj0550170) / Biochem. J. / The determination of enzyme inhibitor constants by DIXON M. (1933)
DWYER , S. B. , AND H. E. UMBARGER. 1968 . Isoleucine and valine metabolism of Escherichia coli. XVI. Pattern of multivalent repression in strain K-12 . J. Bacteriol. 95 : 1680 - 1684 . (10.1128/JB.95.5.1680-1684.1968) / J. Bacteriol. / Isoleucine and valine metabolism of Escherichia coli. XVI. Pattern of multivalent repression in strain K-12 by DWYER S. B. (1968)
EILIC , L. , AND F. C. NEIDHARDT. 1965 . Role of valyl-sRNA synthetase in enzyme repression . Proc. Natl. Acad. Sci. U. S. 53: 539 - 543 . (10.1073/pnas.53.3.539) / Proc. Natl. Acad. Sci. U. / Role of valyl-sRNA synthetase in enzyme repression by EILIC L. (1965)
EZEKIEL , D. H. 1965 . Requirement for p-fluorophenylalanine activation in control of ribonucleic acid synthesis . Biochim. Biophys. Acta 95 : 48 - 53 . (10.1016/0005-2787(65)90209-1) / Biochim. Biophys. Acta / Requirement for p-fluorophenylalanine activation in control of ribonucleic acid synthesis by EZEKIEL D. H. (1965)
FREUNDLICH , M. 1967 . Valyl-transfer RNA: role in repression of the isoleucine-valine enzymes in Escherichia coli . Science 157 : 823 - 825 . (10.1126/science.157.3790.823-a) / Science / Valyl-transfer RNA: role in repression of the isoleucine-valine enzymes in Escherichia coli by FREUNDLICH M. (1967)
FREUNDLICH , M., R. 0. BURNS , A ND H . E. UMBARGER. 1962 . Control of isoleucine, valine and leucine biosynthesis. I. Multivalent repression . Proc. Natl. Acad. Sci. U. S. 48: 1804 - 1808 . (10.1073/pnas.48.10.1804) / Proc. Natl. Acad. Sci. U. / Control of isoleucine, valine and leucine biosynthesis. I. Multivalent repression by FREUNDLICH M., R. (1962)
LEAV r IT, R . I., AND H. E. UMBARGER. 1962 . Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12 . J. Bacteriol. 83 : 624 - 630 . (10.1128/JB.83.3.624-630.1962) / J. Bacteriol. / Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12 by LEAV IT, R (1962)
LOFTFIELD , R. B. , AND E. A. EIGNER. 1966 . The specificity of enzyme reactions. Aminoacylsoluble RNA ligases . Biochim. Biophys. Acta 130 : 426 - 448 . (10.1016/0304-4165(66)90239-X) / Biochim. Biophys. Acta / The specificity of enzyme reactions. Aminoacylsoluble RNA ligases by LOFTFIELD R. B. (1966)
NEIDHARDT , F. C. 1966 . Roles of amino acid activating enzymes in cellular physiology . Bacteriol. Rev. 30 : 701 - 719 . (10.1128/BR.30.4.701-719.1966) / Bacteriol. Rev. / Roles of amino acid activating enzymes in cellular physiology by NEIDHARDT F. C. (1966)
RAMAKRISHNAN , T. , AND E. A. ADELBERG. 1965 . Regulatory mechanisms in the biosynthesis of isoleucine and valine. II. Identification of two operator genes . J. Bacteriol. 89 : 654 - 660 . (10.1128/JB.89.3.654-660.1965) / J. Bacteriol. / Regulatory mechanisms in the biosynthesis of isoleucine and valine. II. Identification of two operator genes by RAMAKRISHNAN T. (1965)
ROTH , J. R. , AND B. N. AME s. 1966 . Histidine regulatory mutants in Salmonella typhimuriwn. II. Histidine regulatory mutants having altered histidyl-tRNA synthetase . J. Mol. Biol. 22 : 325 - 334 . / J. Mol. Biol. / Histidine regulatory mutants in Salmonella typhimuriwn. II. Histidine regulatory mutants having altered histidyl-tRNA synthetase by ROTH J. R. (1966)
SCHLESSINGER , S. , AND B. MAGASANIK. 1964 . Effect of a-methyl histidine on the control of histidine synthesis . J. Mol. Biol. 9 : 670 - 682 . (10.1016/S0022-2836(64)80174-1) / J. Mol. Biol. / Effect of a-methyl histidine on the control of histidine synthesis by SCHLESSINGER S. (1964)
SHEPHARDSON M. AND A. B. PARDEE. 1962. Aspartate transcarbamylase from Escherichia coli p. 925-931. In S. P. Colowick and N. 0. Kaplan [ed.] Methods in enzymology vol. 5. Academic Press Inc. New York. (10.1016/S0076-6879(62)05337-9)
SILBERT , D. F. , G. R. FINK , AND B. N., AmEss. 1966 . Histidine regulatory mutants in Salmo,iella typhimurium. III. A class of regulatory mutants deficient in tRNA for histidine . J. Mol. Biol. 22 : 335 - 347 . 1679 (10.1016/0022-2836(66)90136-7) / J. Mol. Biol. / Histidine regulatory mutants in Salmo,iella typhimurium. III. A class of regulatory mutants deficient in tRNA for histidine by SILBERT D. F. (1966)
ST 0 RMER , F. C., AND H. E. UMBARGER. 1964 . The requirement for flavine adenine dinucleotide in the formation of acetolactate by Salmonella typhimurium extracts . Biochem. Biophys. Res. Commun. 17 : 587 - 592 . (10.1016/0006-291X(64)90071-3) / Biochem. Biophys. Res. Commun. / The requirement for flavine adenine dinucleotide in the formation of acetolactate by Salmonella typhimurium extracts by ST RMER (1964)
SZENTIRMAI , A. , AND H. E. UMBARGER. 1968 . Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine . J. Bacteriol. 95 : 1666 - 1671 . (10.1128/JB.95.5.1666-1671.1968) / J. Bacteriol. / Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine by SZENTIRMAI A. (1968)

Dates

Type	When
Created	5 years, 8 months ago (Jan. 4, 2020, 9:07 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 12:45 p.m.)
Indexed	3 days, 1 hour ago (Sept. 4, 2025, 10 a.m.)
Issued	57 years, 4 months ago (May 1, 1968)
Published	57 years, 4 months ago (May 1, 1968)
Published Print	57 years, 4 months ago (May 1, 1968)

Funders 0

None

BibTeX

@article{Szentirmai_1968, title={Isoleucine and Valine Metabolism of Escherichia coli XV. Biochemical Properties of Mutants Resistant to Thiaisoleucine}, volume={95}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.95.5.1672-1679.1968}, DOI={10.1128/jb.95.5.1672-1679.1968}, number={5}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Szentirmai, A. and Szentirmai, M. and Umbarger, H. E.}, year={1968}, month=may, pages={1672–1679} }

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