DOI: 10.1128/jb.91.3.1201-1209.1966. Phenomenon of Transient Repression in <i>Escherichia coli</i>

Phenomenon of Transient Repression in Escherichia coli

10.1128/jb.91.3.1201-1209.1966

Crossref journal-article

American Society for Microbiology

Journal of Bacteriology (235)

Abstract

Paigen, Kenneth (Roswell Park Memorial Institute, Buffalo, N.Y.). Phenomenon of transient repression in Escherichia coli . J. Bacteriol. 91: 1201–1209. 1966.—A family of mutants has been obtained in Escherichia coli K-12 in which β-galactosidase is not inducible for approximately one cell generation after the cells are transferred to glucose from other carbon sources. After that period; the enzyme can be induced at the level appropriate to glucose-grown cultures of the parent cells. Among a wide variety of carbon sources, the only one capable of eliciting a state of transient repression is glucose. Conversely, transient repression occurs when cells are transferred to glucose from any of a variety of other carbon sources. The only exceptions to this so far discovered are lactose, gluconate, and xylose. Susceptibility to transient repression in mutants can also be induced in glucose-grown cells by a period of starvation. Mutant cells which have become susceptible to transient repression lose susceptibility in the presence of glucose only when they are under conditions which permit active protein synthesis. The presence of an inducer of β-galactosidase is not required during this time, nor does pre-induction for β-galactosidase diminish the susceptibility of mutants. At least two other catabolite repression-sensitive enzymes (galactokinase and tryptophanase) are also sensitive to transient repression, and the two phenomena are probably related. The absolute specificity of glucose and the pattern of response seen after growth in different carbon sources suggest that the endogenous metabolite which produces these repressions is far more readily derived from glucose in metabolism than it is from any other exogenous carbon source.

Bibliography

Paigen, K. (1966). Phenomenon of Transient Repression in Escherichia coli. Journal of Bacteriology, 91(3), 1201â1209.

Authors 1

Kenneth Paigen (first)

References 12 Referenced 36

ANDERSON , E. H. 1946 . Growth requirements of virus-resistant mutants of Escherichia coli strain "B ." Proc. Natl. Acad. Sci. U. S. 32: 120 - 128 . (10.1073/pnas.32.5.120) / Proc. Natl. Acad. Sci. U. / Growth requirements of virus-resistant mutants of Escherichia coli strain "B by ANDERSON E. H. (1946)
Epps, H. M. R., AND E. F. GALE. 1942 . The influence of the presence of glucose during growth on the enzyme activities of Escherichia coli: Comparison of the effect with that produced by fermentation acids . Biochem. J. 36 : 619 - 623 . (10.1042/bj0360619) / Biochem. J. / The influence of the presence of glucose during growth on the enzyme activities of Escherichia coli: Comparison of the effect with that produced by fermentation acids by E. F. (1942)
GALE , E. F. 1943 . Factors influencing the enzymic activities of bacteria . Bacteriol. Rev. 7 : 139 - 173 . (10.1128/br.7.3.139-173.1943) / Bacteriol. Rev. / Factors influencing the enzymic activities of bacteria by GALE E. F. (1943)
Mc FALL , E. , AND J. MANDELSTAM. 1963 . Specific metabolic repression of three induced enzymes in Escherichia coli . Biochem. J. 89 : 391 - 398 . (10.1042/bj0890391) / Biochem. J. / Specific metabolic repression of three induced enzymes in Escherichia coli by FALL E. (1963)
MAGASANIK , B. 1961 . Catabolite repression . Cold Spring Harbor Symp. Quant. Biol. 26 : 249 - 256 . (10.1101/SQB.1961.026.01.031) / Cold Spring Harbor Symp. Quant. Biol. / Catabolite repression by MAGASANIK B. (1961)
MANDELSTAM , J. 1962 . The repression of constitutive 63-galactosidase in Escherichia coli by glucose and other carbon sources . Biochem. J. 82 : 489 - 493 . (10.1042/bj0820489) / Biochem. J. / The repression of constitutive 63-galactosidase in Escherichia coli by glucose and other carbon sources by MANDELSTAM J. (1962)
NEIDHARDT , F. C. 1960 . Mutant of Aerobacter aerogenes lacking glucose repression . J. Bacteriol. 80 : 536 - 543 . (10.1128/jb.80.4.536-543.1960) / J. Bacteriol. / Mutant of Aerobacter aerogenes lacking glucose repression by NEIDHARDT F. C. (1960)
NEIDHARDT , F. C. , AND B. MAGASANIK. 1956 . Inhibitory effect of glucose on enzyme formation . Nature 178 : 801 - 802 . (10.1038/178801b0) / Nature / Inhibitory effect of glucose on enzyme formation by NEIDHARDT F. C. (1956)
NEIDHARDT , F. C. , AND B. MAGASANIK. 1957 . Reversal of the glucose inhibition of histidase biosynthesis in Aerobacter aerogenes . J. Bacteriol. 73 : 253 - 259 . (10.1128/jb.73.2.253-259.1957) / J. Bacteriol. / Reversal of the glucose inhibition of histidase biosynthesis in Aerobacter aerogenes by NEIDHARDT F. C. (1957)
PAIGEN , K. 1963 . Changes in the inducibility of galactokinase and FB-galactosidase during inhibition of growth in Escherichia coli . Biochim. Biophys. Acta 77 : 318 - 328 . (10.1016/0006-3002(63)90502-X) / Biochim. Biophys. Acta / Changes in the inducibility of galactokinase and FB-galactosidase during inhibition of growth in Escherichia coli by PAIGEN K. (1963)
PARDEE , A. B. , AND L. H. PRE sr IDGE . 1961 . The initial kinetics of enzyme induction . Biochim. Biophys. Acta 49 : 77 - 88 . (10.1016/0006-3002(61)90871-X) / Biochim. Biophys. Acta / The initial kinetics of enzyme induction by PARDEE A. B. (1961)
VOGEL H. J. 1957. Repression and induction as control mechanisms of enzyme biosynthesis: The "adaptive" formation of acetyl-ornithinase p. 276-289. In W. M. McElroy and B. Glass [ed.] Chemical basis of heredity. Johns Hopkins Press Baltimore.

Dates

Type	When
Created	5 years, 7 months ago (Jan. 4, 2020, 8:51 p.m.)
Deposited	4 years, 1 month ago (July 29, 2021, 1:21 p.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 12:20 p.m.)
Issued	59 years, 6 months ago (March 1, 1966)
Published	59 years, 6 months ago (March 1, 1966)
Published Print	59 years, 6 months ago (March 1, 1966)

Funders 0

None

BibTeX

@article{Paigen_1966, title={Phenomenon of Transient Repression in Escherichia coli}, volume={91}, ISSN={1098-5530}, url={http://dx.doi.org/10.1128/jb.91.3.1201-1209.1966}, DOI={10.1128/jb.91.3.1201-1209.1966}, number={3}, journal={Journal of Bacteriology}, publisher={American Society for Microbiology}, author={Paigen, Kenneth}, year={1966}, month=mar, pages={1201–1209} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        1,
        11
      ]
    ],
    "date-time": "2024-01-11T17:20:07Z",
    "timestamp": 1704993607138
  },
  "reference-count": 12,
  "publisher": "American Society for Microbiology",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            1966,
            3,
            1
          ]
        ],
        "date-time": "1966-03-01T00:00:00Z",
        "timestamp": -121132800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://journals.asm.org/non-commercial-tdm-license"
    }
  ],
  "content-domain": {
    "domain": [
      "journals.asm.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        1966,
        3
      ]
    ]
  },
  "abstract": "<jats:p>\n            <jats:sc>Paigen, Kenneth</jats:sc>\n            (Roswell Park Memorial Institute, Buffalo, N.Y.). Phenomenon of transient repression in\n            <jats:italic>Escherichia coli</jats:italic>\n            . J. Bacteriol.\n            <jats:bold>91:</jats:bold>\n            1201\u20131209. 1966.\u2014A family of mutants has been obtained in\n            <jats:italic>Escherichia coli</jats:italic>\n            K-12 in which \u03b2-galactosidase is not inducible for approximately one cell generation after the cells are transferred to glucose from other carbon sources. After that period; the enzyme can be induced at the level appropriate to glucose-grown cultures of the parent cells. Among a wide variety of carbon sources, the only one capable of eliciting a state of transient repression is glucose. Conversely, transient repression occurs when cells are transferred to glucose from any of a variety of other carbon sources. The only exceptions to this so far discovered are lactose, gluconate, and xylose. Susceptibility to transient repression in mutants can also be induced in glucose-grown cells by a period of starvation. Mutant cells which have become susceptible to transient repression lose susceptibility in the presence of glucose only when they are under conditions which permit active protein synthesis. The presence of an inducer of \u03b2-galactosidase is not required during this time, nor does pre-induction for \u03b2-galactosidase diminish the susceptibility of mutants. At least two other catabolite repression-sensitive enzymes (galactokinase and tryptophanase) are also sensitive to transient repression, and the two phenomena are probably related. The absolute specificity of glucose and the pattern of response seen after growth in different carbon sources suggest that the endogenous metabolite which produces these repressions is far more readily derived from glucose in metabolism than it is from any other exogenous carbon source.\n          </jats:p>",
  "DOI": "10.1128/jb.91.3.1201-1209.1966",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2020,
        1,
        5
      ]
    ],
    "date-time": "2020-01-05T01:51:56Z",
    "timestamp": 1578189116000
  },
  "page": "1201-1209",
  "update-policy": "http://dx.doi.org/10.1128/asmj-crossmark-policy-page",
  "source": "Crossref",
  "is-referenced-by-count": 36,
  "title": "Phenomenon of Transient Repression in\n            <i>Escherichia coli</i>",
  "prefix": "10.1128",
  "volume": "91",
  "author": [
    {
      "given": "Kenneth",
      "family": "Paigen",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Department of Experimental Biology, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York"
        }
      ]
    }
  ],
  "member": "235",
  "reference": [
    {
      "key": "p_1",
      "doi-asserted-by": "crossref",
      "first-page": "120",
      "DOI": "10.1073/pnas.32.5.120",
      "article-title": "Growth requirements of virus-resistant mutants of Escherichia coli strain \"B",
      "author": "ANDERSON E. H.",
      "year": "1946",
      "unstructured": "ANDERSON , E. H. 1946 . Growth requirements of virus-resistant mutants of Escherichia coli strain \"B .\" Proc. Natl. Acad. Sci. U. S. 32: 120 - 128 .",
      "journal-title": "Proc. Natl. Acad. Sci. U."
    },
    {
      "key": "p_2",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1042/bj0360619",
      "article-title": "The influence of the presence of glucose during growth on the enzyme activities of Escherichia coli: Comparison of the effect with that produced by fermentation acids",
      "volume": "36",
      "author": "E. F.",
      "year": "1942",
      "unstructured": "Epps, H. M. R., AND E. F. GALE. 1942 . The influence of the presence of glucose during growth on the enzyme activities of Escherichia coli: Comparison of the effect with that produced by fermentation acids . Biochem. J. 36 : 619 - 623 .",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_3",
      "doi-asserted-by": "crossref",
      "first-page": "139",
      "DOI": "10.1128/br.7.3.139-173.1943",
      "article-title": "Factors influencing the enzymic activities of bacteria",
      "volume": "7",
      "author": "GALE E. F.",
      "year": "1943",
      "unstructured": "GALE , E. F. 1943 . Factors influencing the enzymic activities of bacteria . Bacteriol. Rev. 7 : 139 - 173 .",
      "journal-title": "Bacteriol. Rev."
    },
    {
      "key": "p_4",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1042/bj0890391",
      "article-title": "Specific metabolic repression of three induced enzymes in Escherichia coli",
      "volume": "89",
      "author": "FALL E.",
      "year": "1963",
      "unstructured": "Mc FALL , E. , AND J. MANDELSTAM. 1963 . Specific metabolic repression of three induced enzymes in Escherichia coli . Biochem. J. 89 : 391 - 398 .",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_5",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1101/SQB.1961.026.01.031",
      "article-title": "Catabolite repression",
      "volume": "26",
      "author": "MAGASANIK B.",
      "year": "1961",
      "unstructured": "MAGASANIK , B. 1961 . Catabolite repression . Cold Spring Harbor Symp. Quant. Biol. 26 : 249 - 256 .",
      "journal-title": "Cold Spring Harbor Symp. Quant. Biol."
    },
    {
      "key": "p_6",
      "doi-asserted-by": "crossref",
      "first-page": "489",
      "DOI": "10.1042/bj0820489",
      "article-title": "The repression of constitutive 63-galactosidase in Escherichia coli by glucose and other carbon sources",
      "volume": "82",
      "author": "MANDELSTAM J.",
      "year": "1962",
      "unstructured": "MANDELSTAM , J. 1962 . The repression of constitutive 63-galactosidase in Escherichia coli by glucose and other carbon sources . Biochem. J. 82 : 489 - 493 .",
      "journal-title": "Biochem. J."
    },
    {
      "key": "p_7",
      "doi-asserted-by": "crossref",
      "first-page": "536",
      "DOI": "10.1128/jb.80.4.536-543.1960",
      "article-title": "Mutant of Aerobacter aerogenes lacking glucose repression",
      "volume": "80",
      "author": "NEIDHARDT F. C.",
      "year": "1960",
      "unstructured": "NEIDHARDT , F. C. 1960 . Mutant of Aerobacter aerogenes lacking glucose repression . J. Bacteriol. 80 : 536 - 543 .",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "p_8",
      "doi-asserted-by": "crossref",
      "first-page": "801",
      "DOI": "10.1038/178801b0",
      "article-title": "Inhibitory effect of glucose on enzyme formation",
      "volume": "178",
      "author": "NEIDHARDT F. C.",
      "year": "1956",
      "unstructured": "NEIDHARDT , F. C. , AND B. MAGASANIK. 1956 . Inhibitory effect of glucose on enzyme formation . Nature 178 : 801 - 802 .",
      "journal-title": "Nature"
    },
    {
      "key": "p_9",
      "doi-asserted-by": "crossref",
      "first-page": "253",
      "DOI": "10.1128/jb.73.2.253-259.1957",
      "article-title": "Reversal of the glucose inhibition of histidase biosynthesis in Aerobacter aerogenes",
      "volume": "73",
      "author": "NEIDHARDT F. C.",
      "year": "1957",
      "unstructured": "NEIDHARDT , F. C. , AND B. MAGASANIK. 1957 . Reversal of the glucose inhibition of histidase biosynthesis in Aerobacter aerogenes . J. Bacteriol. 73 : 253 - 259 .",
      "journal-title": "J. Bacteriol."
    },
    {
      "key": "p_10",
      "doi-asserted-by": "crossref",
      "first-page": "318",
      "DOI": "10.1016/0006-3002(63)90502-X",
      "article-title": "Changes in the inducibility of galactokinase and FB-galactosidase during inhibition of growth in Escherichia coli",
      "volume": "77",
      "author": "PAIGEN K.",
      "year": "1963",
      "unstructured": "PAIGEN , K. 1963 . Changes in the inducibility of galactokinase and FB-galactosidase during inhibition of growth in Escherichia coli . Biochim. Biophys. Acta 77 : 318 - 328 .",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_11",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1016/0006-3002(61)90871-X",
      "article-title": "The initial kinetics of enzyme induction",
      "volume": "49",
      "author": "PARDEE A. B.",
      "year": "1961",
      "unstructured": "PARDEE , A. B. , AND L. H. PRE sr IDGE . 1961 . The initial kinetics of enzyme induction . Biochim. Biophys. Acta 49 : 77 - 88 .",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "p_12",
      "unstructured": "VOGEL H. J. 1957. Repression and induction as control mechanisms of enzyme biosynthesis: The \"adaptive\" formation of acetyl-ornithinase p. 276-289. In W. M. McElroy and B. Glass [ed.] Chemical basis of heredity. Johns Hopkins Press Baltimore."
    }
  ],
  "container-title": "Journal of Bacteriology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/jb.91.3.1201-1209.1966",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://journals.asm.org/doi/pdf/10.1128/jb.91.3.1201-1209.1966",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        29
      ]
    ],
    "date-time": "2021-07-29T17:21:19Z",
    "timestamp": 1627579279000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://journals.asm.org/doi/10.1128/jb.91.3.1201-1209.1966"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1966,
        3
      ]
    ]
  },
  "references-count": 12,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          1966,
          3
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1128/jb.91.3.1201-1209.1966"
  ],
  "URL": "http://dx.doi.org/10.1128/jb.91.3.1201-1209.1966",
  "relation": {},
  "ISSN": [
    "0021-9193",
    "1098-5530"
  ],
  "subject": [],
  "container-title-short": "J Bacteriol",
  "published": {
    "date-parts": [
      [
        1966,
        3
      ]
    ]
  },
  "assertion": [
    {
      "value": "2021-02-01",
      "order": 2,
      "name": "published",
      "label": "Published",
      "group": {
        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}